邓宏魁 Hongkui Deng
Principal Investigator, Changjiang Professor, Key Laboratory of Chemical Genomics, PKUSZ
Tel: +86-10-6275-6474
Fax: +86-10-6275-6954
Email: hongkui_deng@pku.edu.cn
Group Member: Yan Shi, Associate Professor, E-mail: shiyan@szpku.edu.cn
EDUCATION & EXPERIENCE
2001 - present Professor of Cell Biology, Peking University
1998 - 2001 Director of Molecular Biology, Viacell, Inc. Worcester, MA
1995 - 1998 Aaron Diamond Postdoctoral Fellow, NYU medical Center
1990 - 1995 Ph.D., University of California, Los Angeles
1984 - 1987 M.Sc., Shanghai Second Medical University
1980 - 1984 B.Sc., Wuhan University
FELLOWSHIPS AND AWARDS
1995 Aaron Diamond Fellowship
2000 Cheung Kong Scholarship
2001 Natural Science Foundation of China Awards for Outstanding Young Scientists
2005 Bill and Melinda Gates Foundation
2006 Lilly-Asian Scientific Excellence Award
RESEARCH INTEREST:
- 1. Nuclear reprogramming and directed differentiation of human embryonic stem cells
- 2. Small molecules targeting cancer stem cells
- 3. Animal models for disease research
SELECTIVE PUBLICATIONS
1. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. “Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.” Cell Res. 2010 Oct 19. [Epub ahead of print]
2. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S. “Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors.” Cell Stem Cell 2009, 4(1):16-19.
- 3. Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H. “Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.“ Cell Stem Cell 2008, 3(6):587-590.
- 4. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H. “Two supporting factors greatly improve the efficiency of human iPSC generation.” Cell Stem Cell 2008, 3(5):475-479.
- 5. Yang W, Wei W, Shi C, Zhu J, Ying W, Shen Y, Ye X, Fang L, Duo S, Che J, Shen H, Ding S, Deng H. “Pluripotin combined with LIF greatly promotes the derivation of ES cell lines from refractory strains.” Stem Cells 2008 Dec 4. [Epub ahead of print]
- 6. Zhang P, Li J, Wang C, Tan Z, Liu T, Chen L, Yong J, Jiang W, Sun X, Ding M, and Deng H. “Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells”. Blood 2008, 111, 1933-1941.
7. Jiang W, Bai Z, Zhang D, Shi Y, Yong J, Chen S, Ding M and Deng H. “Differentiation of Mouse Nuclear Transfer Embryonic Stem Cells into Functional Pancreatic Beta Cells”. Diabetologia. 2008, in press.
8. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H and Xiong J. “Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation”. Blood 2007, 110, 3601-3609.
9. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M and Deng H. “Directed differentiation of human embryonic stem cells into functional hepatic cells”. Hepatology 2007, 45, 1229-1239.
10. Qin H, Yu T, Qing T, Liu Y, Zhao Y, Cai J, Li J, Song Z, Qu X, Zhou P, Wu J, Ding M and Deng H. “Regulation of apoptosis and differentiation by p53 in human embryonic stem cells”. J. Biol. Chem. 2007, 282, 5842-5852.
11. Deng, H. Unutmaz, D.KewalRamani, V. N. Littman, D. R. “Expression cloning of new receptors used by simian and human immunodeficiency viruses”. Nature 1997, 388, 296-300.
12. Deng, H., D. Unutmaz, V. N. KewalRamani, et al., “Identification of a major co-receptor for primary isolates of HIV-1”. Nature 1996, 381, 661-666.
PATENTS
ZL03143037.6;
ZL200310101980.6;
PCT/CN2006/00683;
200610078382.5;
200610089307.9