Gan Group
化学生物学与生物技术学院

Gan

电子版照片-gan

          甘文标教授  

研究领域: 神经生物学

电话: +86-13823577361

邮箱 : Wenbiao.Gan@med.nyu.edu

 

一. 研究领域

我们的研究主要集中在理解神经回路在稳定地保存先前记忆的同时,又是如何来存储整合新的信息。通过利用我们开发的经颅双光子显微成像技术,研究在体小鼠大脑皮层的突触后树突棘的变化,我们发现大脑皮层不同区域的树突棘大部分是可以在成年后的生活中保存下来的,从而可以作为一个长期信息存储的结构基础。近几年,我们探索了在体小鼠大脑皮层在运动学习记忆,条件性恐惧记忆及其消退,应激糖皮质激素,小胶质细胞和睡眠这些情况下,树突棘可塑性是如何发生变化的。最近,我们又开发了一系列新的行为范式和研究方法,使我们能够在小鼠清醒时对大脑皮层锥体神经元的树突和树突脊进行钙成像。相信有了这些新工具,我们能够更深入的了解大脑的功能及其相关疾病的病理机制。

二. 教育经历

博士(PhD), 1989年 至 1995 年, 美国哥伦比亚大学

硕士(MSc), 1986年 至 1989 年, 清华大学生物科学与技术系

学士(BSc), 1982年 至 1986年, 清华大学电机系

三. 工作经历

终身教授,2012年 至今,美国纽约大学

兼职教授,2009 年 至今,北京大学深圳研究生院

副教授,2006年 至 2012年,美国纽约大学

助理教授, 1999年 至 2006 年, 美国纽约大学

博士后, 1995 年 至1999 年, 美国华盛顿大学 

 四. 获奖情况

  • 1995.美国哥伦比亚大学Peter Sajovic 纪念奖
  • 1996.美国国家卫生研究院研究服务奖
  • 2000.Ellison医学基金会新学者奖
  • 2000.美国纽约大学Whitehead 青年教师奖
  • 2002.阿尔茨海默病协会研究奖
  • 2006~2007.学习与记忆Dart学者

 五.代表性论文

最新:

Li W, Ma L, Yang G, Gan WB.(2017)REM sleep selectively prunes and maintains new synapses in development and learning. Nat Neurosci. 2017 Mar;20(3):427-437.

Zhao R, Hu W, Tsai J, Li W, Gan WB.(2017)Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease.Mol Neurodegener. 2017 Jun 12;12(1):47.

早期:

1. Cichon J,Gan WB.(2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature.2015 Apr 9;520(7546):180-5.

2. Yang G, Lai CS, Cichon J, Ma L, Li W, Gan WB.(2014) Sleep promotes branch-specific formation of dendritic spines after learning. Science. 2014 Jun 6;344(6188):1173-8.

3. Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR,Gan WB.(2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013 Dec 19;155(7):1596-609.

4. Lai CS, Franke TF, Gan WB.(2012) Opposite effects of fear conditioning and extinction on dendritic spine remodelling. Nature. 19;483(7387):87-91.

5. Pan, F., Aldridge, G.M., Greenough, W.T, Gan, W-B. (2010) Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile x syndrome. Proc Natl Acad Sci U S A. 107(41):17768-73.

6. Yang, G., Pan, F., Gan, W-B. (2009) Stably maintained dendritic spines are associated with lifelong memories. Nature. 462:920-4.

7. Xu, H.T., Pan, F., Yang, G., Gan, W-B. (2007) Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci. 10:549-51.

8. Zuo, Y., Yang, G., Kwon, E., Gan, W-B (2005) Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature.  436:261-5.

9. Grutzendler, J., Kasthuri, N., Gan, W-B. (2002) Long-term dendritic spine stability in the adult cortex.  Nature. 420:812-816.

10. Gan, W-B., Lichtman, J.W. (1998) Synaptic segregation at the developing neuromuscular junction.  Science  282:1508-1511.

 

Gan

EDUCATION

1986-1989    B.S. in  Laser Physics           Tsinghua University, Beijing B.E. 

1989-1995    Ph. D. in  Neurobiology        Columbia University, New York  

 EXPERIENCE:

1995-1999   Postdoc in Neurobiology, Washington University, St. Louis 

1999-2006   Assistant Professor,  Skirball Institute, Molecular Neurobiology  Program and Department of Physiology and Neuroscience, NYU School of Medicine

2006-          Tenure Professor, Skirball Institute, Molecular Neurobiology Program and Department of Physiology and Neuroscience, NYU School of Medicine

 HONORS:

1989            First Award for M.S. thesis, Department of Biological Sciences and Biotechnology, TsinghuaUniversity

1991            Science and Technology Award for M.S. thesis work on the studies of the multi-channel VEP topography and its clinical use, Beijing Medical University

1995            The Peter Sajovic Memorial Prize for outstanding work in Biology, Department of Biological Sciences, ColumbiaUniversity

1996-1999   National Research Service Award, NIH

2000            Whitehead Fellowship for Junior Faculty in Biomedical or Biological Science, New YorkUniversity

2000-2004   New Scholar Award, Ellison Medical Foundation

2002-2005   Investigator Initiated Research Grant Award, Alzheimers Association

2006-2007   Dart Scholar in learning and memory, Marine Biological Laboratory

 RESEARCH INTERESTS:

We are interested in understanding synaptic structure and function in the living brain.Specifically,we examine the development and maintenance of synapses with various techniques including transcranial two-photon imaging, molecular biology and electrophysiology.We also investigate how to prevent abnormal synapse loss in mouse models of neurodegenerative diseases.