Gan Group
化学生物学与生物技术学院

Publications

近期发表论文:

1. Li W, Ma L, Yang G, Gan WB.(2017)REM sleep selectively prunes and maintains new synapses in development and learning. Nat Neurosci. 2017 Mar;20(3):427-437.

2. Zhao R, Hu W, Tsai J, Li W, Gan WB.(2017)Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease.Mol Neurodegener. 2017 Jun 12;12(1):47.

3. Qiao Q, Ma L, Li W, Tsai JW, Yang G, Gan WB. (2015) Long-term stability of axonal boutons in the mouse barrel cortex. EMBO Mol Med. 2015 Jul 2;7(9):1179-97. 

4. Ma L, Qiao Q, Tsai JW, Yang G, Li W, Gan WB. (2015) Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex. Dev Neurobiol. 2015 Jun 1.

5. Cichon J, Gan WB. (2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature. 2015 Apr 9;520(7546):180-5. 

早期发表论文:

1. Yang G, Lai CS, Cichon J, Ma L, Li W, Gan WB. (2014) Sleep promotes branch-specific formation of dendritic spines after learning. Science. 344(6188):1173-8.

2.  Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell.155(7):1596-609.

3.  Lai CS, Franke TF, Gan WB.(2012) Opposite effects of fear conditioning and extinction on dendritic spine remodelling. Nature. 19;483(7387):87-91.

4.  Liston C, Gan W-B. (2011) Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo. Proc Natl Acad Sci U S A. 108(38):16074-9.

5. Pan, F., Aldridge, G.M., Greenough, W.T, Gan, W-B. (2010) Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile x syndrome. Proc Natl Acad Sci U S A. 107(41):17768-73.

6. Parkhurst CN, Gan, W-B. (2010) Microglia dynamics and function in the CNS. Curr Opin Neurobiol. 20(5):595-600.

7. Yang, G., Pan, F., Parkhurst, CN., Grutzendler, J., Gan, W-B. (2010) Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc. 5(2):201-8.

8. Yang, G., Pan, F., Gan, W-B. (2009) Stably maintained dendritic spines are associated with lifelong memories. Nature. 462:920-4.9.

9. Wu, S.H., Arevalo, J.C., Sarti, F., Tessarollo, L., Gan, W-B., Chao, M.V. (2009)  Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo.  Dev Neurobiol. 69(9):547-57.

10. Bhatt, D., Zhang, S., Gan, W-B. (2009) Dendritic spine dynamics.  Annual Review of Physiology. 71:261-82.

11. Gan, W-B., Kasthuri, N., Yang, G. (2008) Spine plasticity.  New Encyclopedia of Neuroscience.  Edited by Larry R. Squire.

12. Pan, F., Gan, W-B. (2008) Two-photon imaging of dendritic spine development.  Developmental Neurobiology. 68:771-8.

13. Xu, H.T., Pan, F., Yang, G., Gan, W-B. (2007) Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci. 10:549-51.

14. Grutzendler, J., Helmin, K., Tsai, J., Gan, W-B. (2007)  Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Ann N Y Acad Sci. 1097:30-9.

15. Haynes, S.E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M.E., Gan, W-B, Julius, D. (2006) The P2Y(12) receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci. 9:1512-9. 2006.

16. Grutzendler, J.G., Gan, W-B. (2006) Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. NeuroRx. 3:489-96.

17. Zhang, Z.G., Zhang, L., Ding, G., Jiang, Q., Zhang, R.L., Zhang, X., Gan, W-B, Chopp, M. (2005) A model of mini-embolic stroke offers measurements of the neurovascular unit response in the living mouse. Stroke. 36:2701-4.

18. Zuo, Y., Yang, G., Kwon, E., Gan, W-B(2005) Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature.  436:261-5.

19. Yang, G., Gong, Y-D., Gong, K., Jiang, W-L., Kwon, E., Wang, P., Zheng, H., Zhang, X-F., Gan, W-B., Zhao, N-M (2005) Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (app) and app-like protein 2. Neurosci Lett.

20. Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littmann, D.R., Dustin, M.L., Gan, W-B (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci. 8:752-8.

21. Zuo, Y., Lin, A., Chang, P., Gan, W-B (2005) Development of long-term dendritic spine stability in diverse regions of cerebral cortex. Neuron. 46:1-9.

22. Gan, W-B, Grutzendler, J., Wong, R.O., Lichtman, J.W. (2005) A practical Guide: Ballistic Delivery of dyes for structural and functional studies of the nervous system.  In Imaging in Neuroscience and Development.  A laboratory Manual. Edited by Rafael Yuste and Arthur Konnerth.  CSHL Press. pp111-118.

23. Grutzendler, J., Gan, W-B (2005) A practical Guide: Long-term two-photon transcranial imaging of synaptic structure is in the living brain.  In Imaging in Neuroscience and Development.  A laboratory Manual. Edited by Rafael Yuste and Arthur Konnerth.  CSHL Press. pp185-190.

24. Wang, P., Yang, G., Mosier, D.R., Chang, P., Zaidi, T., Gong, Y-D., Zhao, N-M., Dominguez, B., Lee, K-F., Gan, W-B., Zheng, H., (2005) Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2. J Neurosci., 25:1219--1225.

25. Li, Q., Lee, J.S., Ha, C., Park, C.B., Yang, G., Gan, W-B., Chang, Y.T.  (2004) Solid-phase synthesis of styryl dyes and their application as amyloid sensors. Angew Chem Int Ed Engl. 43:6331-5.

26. Bishop, D.L., Misgeld, T., Walsh, M.K., Gan, W-B., Lichtman, J.W. (2004) Axon branch removal at developing synapses by axosome shedding.  Neuron. 44:651-61.

27. Tsai, J., Grutzendler, J., Duff, K., Gan, W-B. (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci. 7:1181-3 [Epub ahead of print].

28. Coggan, J.S., Grutzendler, J., Bishop, D.L., Cook, M.R., Gan, W-B., Heym, J., Lichtman, J.W. (2004) Age-associated synapse elimination in mouse parasympathetic ganglia. J Neurobiol. 60:214-26.

29. Sadowski, M., Pankiewicz, J., Scholtzova,H., Tsai,J., Li, Y., Carp, R.I., Meeker, H.C., Gambetti, P., Debnath, M., Mathis, C.A., Shao, L., Gan, W-B., Klunk, W.E., Wisniewski, T. (2004) Targeting prion amyloid deposits in vivo.  J Neuropathol Exp Neurol. 63(7):775-84.

30. Yong, J., Gong, Y.D., Gan W-B., Beach, T., Holtzman, D.M., Wisniewski, T.(2003) Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer��s disease patients.  Neuroscience. 122:305-15.

31. Gan W-B. (2003) Glutamate-dependent stabilization of presynaptic terminals. Neuron. 38:677-8.

32. Gan, W-B., Kwon, E, Feng, G, Sanes J.R., Lichtman, J.W. (2003) Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion.  Nat Neurosci. 6:956-960.

33. Grutzendler, J., Tsai, J., Gan, W-B.  (2003) Rapid labeling of neuronal populations through ballistic delivery of fluorescent indicators.  Methods.  30:79-85.

34. Grutzendler, J., Kasthuri, N., Gan, W-B. (2002) Long-term dendritic spine stability in the adult cortex.  Nature. 420:812-816.

35. Kettunen, P., Demas, J., Lohmann, C., Kasthuri, N., Gong, Y.D., Wong, R.O.L., Gan, W-B. (2002) Imaging calcium dynamics in the nervous system by means of ballistic delivery of indicators. J. Neurosci. Method. 119(1): 37-43.

36. Keller-Peck, C.R., Walsh, M.K., Gan, W-B., Feng, G., Sanes, J.R., Lichtman, J.W. (2001) Asynchronous synapse elimination in neonatal motor units: studies using gfp transgenic mice. Neuron 31:381-94.

37. Gan, W-B., Grutzendler, J., Wong, W-T., Wong, R.O.L., Lichtman, J.W. (2000) Multicolor  DiOlistic  labeling of neuronal circuits using lipophilic dye combinations. Neuron 27: 219-225.

38.  Gan, W-B., Bishop, D., Turney, S.G., Lichtman, J.W. (1999) Vital imaging and ultrastructural analysis of individual axon terminals labeled by iontophoretic application of lipophilic dye. J. Neurosci. Method.  93(1):13-20.

39.  Gan, W-B.  (1999) TrkB works at postsynaptic sites.  Neuron 24: 491-492.

40.  Gan, W-B., Wong, V.Y., Phillips, A., C, huck, M., Gershon, T., Macagno, E.R.  (1999) Cellular expression of a leech Netrin suggests roles in the formation of longitudinal nerve tracts and in regional innervation of peripheral targets.  J. Neurobiol.  40:103-115.

41.  Gan, W-B., Lichtman, J.W. (1998) Synaptic segregation at the developing neuromuscular junction.  Science  282:1508-1511.

42.  Gan, W-B., Macagno, E.R. (1997) Competition among the axonal projections of an identified neuron contributes to the retraction of some of those projections.  J. Neurosci. 17(11): 4293-4301.

43.  Becker, T., Berliner, A.J., Nitabach, M.N., Gan, W-B., Macagno, E.R. (1995) Target-induced neurogenesis in the leech CNS involves efferent projections to the target.  Development 121(2): 359-369.

44.  Wong, V.Y., Aisemberg, G.O., Gan, W-B., Macagno, E.R. (1995) The leech homeobox gene Lox4 may determine segmental differentiation of identified neurons.   J. Neurosci.  15(8):5551-59.

45.  Gan, W-B., Macagno, E.R. (1995) Developing neurons use a pioneers peripheral arbor to establish their terminal fields. J. Neurosci. 15(5): 3254-62.

46.  Gan, W-B., Macagno, E.R. (1995) Interactions between segmental homologues and between isoneuronal branches guide the formation of sensory terminal fields.  J. Neurosci. 15(5): 3243-53.

47.  Zhao, K-X., Liu, J-Q., Guo, J-Q., Gan, W-B. (1990) An investigation of the multichannel VEP topography by full field stimulation in functional amblyopia of children. Chung-Hua-Yen-Ko-Tsa-Chih. 26(2): 68-72.