一、会议背景：
细胞内钙离子动员是一种普遍存在的信号机制，调节着几乎所有细胞活动的各个方面。在1989年和1995年，我们实验室发现了两个新的第二信使——环腺苷二磷酸核糖（cADPR）和烟酸腺嘌呤二核苷酸磷酸（NAADP），它们可以动员三个生物界不同细胞系统的细胞内钙库。和之前发现的三磷酸肌醇（IP3）相似，cADPR可以释放内质网钙库；NAADP则不同，它靶向酸性内吞-溶酶体钙库。
本会议由我们、韩国全北国立大学医学院的Prof. Kim Uh-Hyun和日本金沢大学的Prof. Haruhiro Higashida共同发起，集中探讨NAD相关的信号功能，从2011年开始在中日韩三国轮流举办。2019.11.29-12.1在中国深圳成功举办了第七届NAD亚洲会议。会议一共邀请了22位来自中国、韩国、日本、英国、意大利等国家的专家给了学术报告，包括了4个大的主题：
- Production of nucleotide messengers.
- Nucleotide messengers and calcium signaling.
- SARM1.
- Biological functions of CD38 and Sirtuins.
二、会议日程：
Program Agenda
2019 A3 Meeting on NAD and CD38/Nucleotide Messenger Signaling
Nov 29 – Dec 1, 2019
| 2019.11.29 | |||||
| 16:00-21:00 | Shenzhen Airport à Lia Charlton hotel | ||||
| 16:00-21:00 | REGISTRATION | Lobby | |||
| 19:00-21:00 | WELCOME DINNER & Wines | 2F Elite Room (二楼聚贤厅) | |||
| 2019.11.30 | |||||
| 7:30-12:00 Registration Lobby | |||||
| 7:30-9:30 | BREAKFAST | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| 9:30-9:45 | OPENING remarks Conference Room (4F Juzhi，4楼聚智厅) | ||||
| Presentations Conference Room (4F Juzhi，4楼聚智厅) | |||||
| 9:45-11:45 | Production of nucleotide messengers. Chair: Patel, S | ||||
| 30’ | HC Lee李汉璋 | Biogenesis of cADPR. | |||
| 30’ | Uh-Hyun Kim | NAADP biosynthesis by CD38 | |||
| 30’ | Antonio De Flora | Paracrine type II CD38-mediated regulation of biological processes | |||
| 30’ | LH Zhang 张礼和 | Design and synthesis of cADPR mimics and Inhibitors of CD38 | |||
| 11:45-12:00 | TAKING photograph (hotel entrance，酒店门口水池) | ||||
| 12:00-13:00 | LUNCH | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| Presentations | Conference Room (4F Juzhi，4楼聚智厅) | ||||
| 13:00-14:40 | Nucleotide messengers and calcium signaling. Chair: Lee, HC | ||||
| 30’ | Sandip Patel | NAADP, TPC and acidic stores | |||
| 30’ | PL Yu余沛霖 | Gating mechanisms of NAD+ metabolites on TRPM2 | |||
| 30’ | Myung-Kwan Han | Itching response by the regulation of intracellular calcium | |||
| 15’ | CX Guo郭晨曦 | TPC and cyclase in Zebrafish | |||
| 14:45-15:00 | Coffee break | ||||
| 15:00-16:45 | SARM1. Chair: Kim, UH | ||||
| 30’ | QW Zhai 翟琦巍 | SARM1 and diabetic peripheral neuropathy. | |||
| 30’ | WW Zeng 曾文文 | SARM1 regulation of neuronal immune response | |||
| 30’ | YJ Zhao 赵永娟 | SARM1 activation mechanism | |||
| 15’ | WH Li 黎婉华 | SARM1 activity imaging | |||
| 16:45-18:00 | Skype talk. Chair: Lee, HC | ||||
| 30’ | Andreas Guse | NAADP, calcium and T-cell activation | |||
| 30’ | Antony Galione | Calcium nanodomains created by TPCs and phagocytosis | |||
| 18:00-22:00 | DINNER | Guomao Rotate Restaurant (by tour bus) | |||
| 2019.12.1 | |||||
| 7:30-9:30 | BREAKFAST | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| Presentations | Conference Room (4F Juzhi，4楼聚智厅) | ||||
| 9:30-13:00 | Biological functions of CD38 and Sirtuins.
Chair: Zhao, YJ & Chung, HT |
||||
| 30’ | Haruhiro Higashida | CD38, CD157 and RAGE in the brain regulate social behavior | |||
| 30’ | Hun-Taeg Chung | CD38 and TTP cross-talk in Inflammation | |||
| 30’ | BH Liu 刘宝华 | Sirt7 regulates hepatic circadian phase coherence and gluconeogenesis | |||
| 11:00-11:10 | Coffee break | ||||
| 30’ | Q Hao 郝权 | Structural and functional study of Sirtuin family proteins | |||
| 30’ | HB Xin 辛洪波 | CD38 and cardiovascular aging | |||
| 15’ | Dae-Ryoung Park | Agonist-induced cADPR and muscle atrophy | |||
| 15’ | So-Young Rah | CD38/cADPR/calcium in glucagon signaling | |||
| 15’ | Yeonsoo Joe | CO-induced TFEB nuclear translocation in mitophagy | |||
| 12:55-13:10 | CLOSING REMARKS: KIM, UH | ||||
| 13:10-14:10 | LUNCH | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| 19:00-22:00 | FAREWELL Dinner & Wines | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| 2019.12.2 | |||||
| 7:30-9:00 | BREAKFAST | 2F The Edge All Day Dining (海角全日制餐厅) | |||
| 9:00-12:00 | Departure | ||||