深圳功能结构生物学重点实验室
Key Laboratory of Structural Biology

文章列表

   2015

   Characterization of Potent Fusion Inhibitors of Influenza Virus. Michael Rowse, Shihong Qiu, Jun Tsao, Tongmei Xian, Sarah Khawaja, Yohei Yamauch,* Zhen Yang,* Guoxin Wang* and Ming Luo*. PLOS ONE, 2015, 10(3):e0122536,

2014

  1.  Discovery and SAR Study of Ppiperidine-based Derivatives as Novel Influenza Virus Inhibitors. Guoxin Wang,* Longjian Chen, Tongmei Xian, Yujie Liang, Xintao Zhang, Zhen Yang,* Ming Luo.* Organic & Biomolecular Chemistry. 2014, 12, 8048-8060.

2.Green TJ, Cox R, Tsao J, Rowse M, Qiu S, Luo M. Common mechanism for RNA encapsidation by negative strand RNA viruses. J Virol. 2014 Jan 15. [Epub ahead of print] PMID: 24429372

2013

1. Yan D, Krumm SA, Sun A, Steinhauer DA, Luo M, Moore ML, Plemper RK. Dual Myxovirus Screen Identifies a Small-Molecule Agonist of the Host Antiviral Response. J Virol. 2013 Oct;87(20):11076-87. Epub 2013 Aug 7. PMID: 23926334

2.  Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA. Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Res. 2013 Jun 1;41(11):5912-5926. Epub 2013 Apr 17. PMID: 23595147

3.  Cox R, Green TJ, Purushotham S, Deivanayagam C, Bedwell GJ, Prevelige PE, Luo M. Structural and functional characterization of the mumps virus phosphoprotein. J Virol. 2013 Jul;87(13):7558-68. doi: 10.1128/JVI.00653-13. Epub 2013 May 1. PMID: 23637399

4.  Liu Y, Meng G, Luo M, Zheng X. Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):280-3. PMID: 235198041.

5.  Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X. Structural and Functional Characterization of K339T Substitution Identified in the PB2 Cap-binding Pocket of Influenza A Virus. J Biol Chem. 2013 PMID: 23436652

2012 

1.   Bai X, Meng G, Luo M, Zheng X. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. J Biol Chem. 2012 Jun 22;287(26):22387-96. PMID: 22573331

2.   Luo M. The nucleocapsid of vesicular stomatitis virus. Sci China Life Sci. 2012 Apr;55(4):291-300. PMID: 22566085

2011

1.  Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, Parker JN, Chen CY. Post-transcriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Mol Cell Biol. 2011. PMID: 21690298

2.  Green TJ, Rowse M, Tsao J, Kang J, Ge P, Zhou ZH, Luo M. Access to RNA encapsidated in the nucleocapsid of vesicular stomatitis virus. J Virol. 2011 Mar;85(6):2714-22. PMID: 21177817

3.  Estevez C, King DJ, Luo M, Yu Q. A single amino acid substitution in the hemagglutinin-neuraminidase protein of Newcastle disease virus results in increased fusion promotion and decreased neuraminidase activities without changes in virus pathotype. J Gen Virol. 2011 Mar;92(Pt 3):544-51. PMID: 21123551

2010

1.  Meng G, Zhao Y, Bai X, Liu Y, Green TJ, Luo M, Zheng X. Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. J Biol Chem. 2010 Dec 17;285(51):39898-904. PMID: 20724479

2.  Sarkar A, Chattopadhyay S, Cox R, Luo M, Banerjee AK. Structural and functional properties of the vesicular stomatitis virus nucleoprotein-RNA complex as revealed by proteolytic digestion. Virology. 2010 May 25;401(1):61-9. PMID: 20206958

3.  Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH. Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science. 2010 Feb 5;327(5966):689-93. PMID: 20133572

4.  Bai X, Meng G, Li G, Luo M, Zheng X. Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):73-5. Epub 2009 Dec 25. PMID: 20057076

5.  Cui Y, Jiao Z, Gong J, Yu Q, Zheng X, Quan J, Luo M, Yang Z. Development of new stereodiverse diaminocyclitols as inhibitors of influenza virus neuraminidase. Org Lett. 2010 Jan 1;12(1):4-7. PMID: 20000379

2009

1. Cox R, Green TJ, Qiu S, Kang J, Tsao J, Prevelige PE, He B, Luo M. Characterization of a Mumps Virus Nucleocapsid-like Particle. J Virol. 2009 83(21):11402-6. PMID: 19692473

2. Green TJ, Luo M. Structure of the vesicular stomatitis virus nucleocapsid in complex with the nucleocapsid-binding domain of the small polymerase cofactor, P. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11713-8. PMID: 19571006

3.  Nayak D, Panda D, Das SC, Luo M, Pattnaik AK. Single-amino-acid alterations in a highly conserved central region of vesicular stomatitis virus N protein differentially affect the viral nucleocapsid template functions. J Virol. 2009 Jun;83(11):5525-34.

4.  Dai X, Li Y, Meng G, Yao S, Zhao Y, Yu Q, Zhang J, Luo M, Zheng X. NADPH is an allosteric regulator of HSCARG. J Mol Biol. 2009 Apr 17;387(5):1277-85. Epub 2009 Feb 28.

5.  Meng G, Bai X, Green TJ, Luo M, Zheng X. Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain-containing protein. Protein Pept Lett. 2009;16(3):336-8.

6.  Brandes M, Willimann K, Bioley G, Lévy N, Eberl M, Luo M, Tampé R, Lévy F, Romero P, Moser B. Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2307-12. Epub 2009 Jan 26.

2008

1.  Luo M, Green TJ, Zhang X, Tsao J, Qiu S. Structural comparison of the nucleoprotein from influenza virus with other NSV nucleoproteins. Options for the control of influenza virus VI. pp 58. 2008.

2.  Green T, Grigorian A, Klyuyeva A, Tuganova A, Luo M, Popov KM. Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2. J Biol Chem. 2008 Jun 6;283(23):15789-98. Epub 2008 Apr 3.

3.  Chen B, Lian M, Xu S, Luo M, Zheng X. A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell. J Biotechnol. 2008. 137(1-4):8-13. PMID: 18675858

4.  Becker MN, Obraztsova M, Kern ER, Quenelle DC, Keith KA, Prichard MN, Luo M, Moyer RW. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.

5.  Zhao Y, Zhang J, Li H, Li Y, Ren J, Luo M, Zheng X. An NADPH sensor protein (HSCARG) downregulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. J Biol Chem. 2008 Feb 8;

6.  Chen Y, Qiu S, Luan C-H, Luo M. In Methods in Molecular Biology. Structural proteomics: A HTP platform for eukaryotic genes. Structural Proteomics- High Throughput Methods. 2008. Eds: Kobe B, Guss M, and Huber T. Humana Press. 426:209-220.

7.  Zhang X, Green TJ, Tsao J, Qiu S, Luo M. Role of intermolecular interactions of vesicular stomatitis virus nucleoprotein in RNA encapsidation. J. Virol. 2008. 82(2):674-82. PMID: 18003727

8.  Lian M, Zhou X, Chen B, Li C, Gu X, Luo M, Zheng X. Identification of the critical regions in hepatitis B virus preS required for its stability. J Pept Sci. 2008. 14(3):307-12. PMID: 17918766

2007

1.  Lian M, Zhou X, Wei L, Qiu S, Zhou T, Li L, Gu X, Luo M, Zheng X. Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients. Virol J. 2007. Sep 24;4(1):93.

2.  Chen Y, Qiu S, Luan C-H, Luo M. Domain Selection Combined with Improved Cloning Strategy for High Throughput Expression of Higher Eukaryotic Proteins. BMC Biotechnology. 2007. 7:45-58.

3.  Luo M, Green TJ, Zhang X, Tsao J, Qiu S. Conserved characteristics of the rhabdovirus nucleoprotein. Virus Res. 2007. Nov;129(2):246-51. PMID: 17764775

4.  Chen Q, You D, Liang Y, Su X, Gu X, Luo M, Zheng X. Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant - insights into inhibitor design. FEBS J. 2007. 274(17):4408-15.

5.  Luo M, Green TJ, Zhang X, Tsao J, Qiu S. Structural comparisons of the nucleoprotein from three negative strand RNA virus families. Virol J. 2007. Jul 10;4(1):72. PMID: 17623082

6.  Zheng X, Dai X, Zhao Y, Chen Q, Lu F, Yao D, Yu Q, Liu X, Zhang C, Gu X, Luo M. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc Natl Acad Sci U S A. 2007. May 22;104(21):8809-14.

7.  Prichard MN, Keith KA, Johnson MP, Harden EA, McBrayer A, Luo M, Qiu S, Chattopadhyay D, Fan X, Torrence PF, Kern ER. Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase. Antimicrob Agents Chemother. 2007. May;51(5):1795-803. PMID: 17325220

 2006

1.  Dai X, Gu X, Luo M, Zheng X. Protein Expression, Crystallization and Preliminary X-Ray Crystallographic Studies on HSCARG from Homo Sapiens. Protein Pept Lett. 2006;13(9):955-7.

2.  Luo M. Structural biology: Antiviral drugs fit for a purpose. Nature. 2006. 443:37-38. PMID: 16915238

3. Green TJ, Zhang X, Wertz GW, Luo M. “Structure of the vesicular stomatitis virus nucleoprotein-RNA complex”. Science. 2006 Jul 21;313(5785):357-60. PMID: 16778022

4.  Rogers JW, Zhou Q, Green TJ, Barr JN, and Luo M. “Purification, crystallization and preliminary X-ray crystallographic analysis of the nucleocapsid protein of Bunyamwera virus”. Acta Cryst. 2006 F62:361-364.

5.  Todd J. Green, and Ming Luo. “Resolution improvement of X-ray diffraction data of crystals of a vesicular stomatitis virus nucleocapsid protein oligomer complexed with RNA”. Acta Ccryst. 2006 D62:498-504. PMID: 16627942

6.  Haitao Ding, Todd J. Green, Shanyun Lu, and Ming Luo. “Crystal structure of the oligomerization domain of the phosphoprotein of vesicular stomatitis virus”. J. Virol. 2006 80(6):2808-14. PMID: 16501089

7.  Hsu HC, Zhou T, Kim H, Barnes S, Yang P, Wu Q, Zhou J, Freeman BA, Luo M, Mountz JD. Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritis. Arthritis Rheum. 2006 Jan;54(1):343-55.

8.  Johnson DH, Tsao J, Luo M, Carson M.  “SGCEdb: a flexible database and web interface integrating experimental results and analysis for structural genomics focusing on Caenorhabditis elegans”. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D471-4.

9.  Chen Q, Hui R, Sun C, Gu X, Luo M, Zheng X. “Soluble expression, purification, and stabilization of a pro-apoptotic human protein, CARP”. Protein Expr Purif. 2006 45:329-334.

2005

1.  Dai XY, Liu Y, Liang YH, Zheng X, Luo M, Li L, Su XD. “Protein expression, crystallization and preliminary X-ray crystallographic studies of YjbK from Bacillus subtilis”. Protein Pept Lett. 2005 Oct;12(7):663-4.

2.  Kataeva I, Chang J, Xu H, Luan CH, Zhou J, Uversky VN, Lin D, Horanyi P, Liu ZJ, Ljungdahl LG, Rose J, Luo M, Wang BC. “Improving solubility of Shewanella oneidensis MR-1 and Clostridium thermocellum JW-20 proteins expressed into Esherichia coli”. J Proteome Res. 2005 Nov-Dec;4(6):1942-51.

3.  Wang BC, Adams MW, Dailey H, DeLucas L, Luo M, Rose J, Bunzel R, Dailey T, Habel J, Horanyi P, Jenney FE Jr, Kataeva I, Lee HS, Li S, Li T, Lin D, Liu ZJ, Luan CH, Mayer M, Nagy L, Newton MG, Ng J, Poole FL 2nd, Shah A, Shah C, Sugar FJ, Xu H. Protein production and crystallization at SECSG -- an overview. J Struct Funct Genomics. 2005;6(2-3):233-43.

4.  Arendall WB 3rd, Tempel W, Richardson JS, Zhou W, Wang S, Davis IW, Liu ZJ, Rose JP, Carson WM, Luo M, Richardson DC, Wang BC. A test of enhancing model accuracy in high-throughput crystallography. J Struct Funct Genomics. 2005;6(1):1-11

5.  Dai X, Chen Q, Lian M, Zhou Y, Zhou M, Lu S, Chen Y, Luo J, Gu X, Jiang Y, Luo M, Zheng X. “Systematic high-yield production of human secreted proteins in Escherichia coli”. Biochem Biophys Res Commun. 2005 Jul 1;332(2):593-601.

6.  Chen Q, Liang Y, Su X, Gu X, Zheng X, Luo M. “Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis”. J Mol Biol. 2005 May 20;348(5):1199-210.

7.  Ren H, Wang L, Bennett M, Liang Y, Zheng X, Lu F, Li L, Nan J, Luo M, Eriksson S, Zhang C, Su XD. “The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus”. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):303-8

2004

1.  Ding H, Green TJ, Luo M. “Crystallization and preliminary X-ray analysis of a proteinase-K-resistant domain within the phosphoprotein of vesicular stomatitis virus (Indiana)”. Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):2087-90. PMID: 15502336

2.  Schormann N, Symersky J, Luo M. “Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans”. Acta Crystallogr D Biol Crystallogr. 2004 60:1840-5.

3.  Lytle BL, Peterson FC, Qiu SH, Luo M, Zhao Q, Markley JL, Volkman BF. “Solution Structure of a Ubiquitin-like Domain from Tubulin-binding Cofactor B.” J Biol Chem. (2004) 279:46787-93.

4.  Luan, C.H.,S. Qiu, J. B. Finley, M. Carson, R. J. Gray, W. Huang, D. Johnson, J. Tsao, J. Reboul, P. Vaglio, D. E. Hill, M. Vidal, L. J. DeLucas, and M. Luo. “High-Throughput Expression of C. elegans Proteins”. Genome Research. (2004) 14:2102-2110. PMID: 15489332

5.  Chen Z, Green TJ, Luo M, Li H. “Visualizing the RNA molecule in the bacterially expressed vesicular stomatitis virus nucleoprotein-RNA complex”. Structure (Camb). 2004 Feb;12(2):227-35. PMID: 14962383

6.  Symersky, J., Y. Zhang, N. Schormann, S. Li, R. Bunzel, P. Pruett, C.-H. Luan and M. Luo. “Structural genomics of Caenorhabditis elegans: structure of the BAG domain”. Acta Cryst. (2004). D60, 1606-1610

7.  Zhou T, Wang H, Luo D, Rowe T, Wang Z, Hogan RJ, Qiu S, Bunzel RJ, Huang G, Mishra V, Voss TG, Kimberly R, Luo M. “ An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies.” J Virol. 2004 Jul;78(13):7217-26. PMID: 15194798

8.  Li R, Ren H, Liang Y, Ding H, Qiu S, Lu S, An J, Li L, Luo M, Zheng X, Su XD. “Protein preparation, crystallization and preliminary X-ray analysis of human adrenal gland protein AD-004.”Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1292-4

9.  Lu S., J. Symersky, S. Li, M. Carson, L. Chen, E. Meehan, and M. Luo. “Structural genomics of Caenorhabditis elegans: Crystal structure of the tropomodulin C-terminal domain”. Proteins. 56: 384-386. (2004)

10.  Lommer, B.S., Ali SM, Bajpai SN, Brouillette WJ, Air GM and Luo M.”A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase”. Acta Cryst. D60:1017-1023. (2004)

11.  Finley JB, Qiu SH, Luan CH, Luo M. “Structural genomics for Caenorhabditis elegans: high throughput protein expression analysis.” Protein Expr Purif. 34:49-55. (2004) PMID: 14766299

2003

1.  Chen Q, You D, Hu M, Gu X, Luo M, Lu S. “Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis”. Protein Expr Purif. 32:239-45. (2003)

2. Symersky J, Li S, Carson M, Luo D, Luan CH, Luo M. “Structural genomics of Caenorhabditis elegans: structure of dihydropteridine reductase”. Proteins. 53:944-6. (2003)

3.  Symersky J, Lin G, Li S, Qiu S, Carson M, Schormann N, Luo M. “Structural genomics of Caenorhabditis elegans: crystal structure of calmodulin”. Proteins. 53:947-9. (2003)

4.  You DL, Qu H, Chen Q, Xing Y, Gu XC, Luo M. [Cloning, Expression and Characterization of the Hypoxanthine-guanine Phosphoribosyltransferase Mutants from T. tengcongensis] Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:853-8. Chinese. (2003)

5.  You D, Chen Q, Liang Y, An J, Li R, Gu X, Luo M, Su XD. Protein preparation, crystallization and preliminary X-ray crystallographic studies of a thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis. Acta Crystallogr D Biol Crystallogr. 59:1863-5. (2003)

6.  Ding, H., S. Qiu, S. Li,, J. Symersky, T. J. Green and M. Luo. “Expression, purification, crystallization of fragments from the C-terminal region of DFF45/ICAD”. ”. Acta Crystallogr D Biol Crystallogr. 59:1323-1326. (2003) PMID: 12832800

7.  Ding H, Qiu S, Bunzel RJ, Luo D, Arabashi A, Lu S, Symersky J, Nagy LA, DeLucas LJ, Li S, Luo M. “Purification, nanocrystallization and preliminary X-ray analysis of a C-terminal part of tropomodulin protein 1, isoform A, from Caenorhabditis elegans”. Acta Crystallogr D Biol Crystallogr. 59:1106-1108. (2003)

8.   Symersky, J., S. Li, M. Carson, and M. Luo. “Structural Genomics of Caenorhabditis elegans: triosephosphate isomerase”. Proteins. 51:484-486. (2003)

9.  Kumar AS, Kallio P, Luo M, Lipton HL. “Amino acid substitutions in VP2 residues contacting sialic acid in low-neurovirulence BeAn virus dramatically reduce viral binding and spread of infection”. J Virol. 77(4): 2709-16. (2003)

10.  Brouillette WJ, Bajpai SN, Ali SM, Velu SE, Atigadda VR, Lommer BS, Finley JB, Luo M, Air GM. “Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents”. Bioorg Med Chem. 11(13): 2739-49. (2003)

11.  Adams, M.W.W., Dailey, H.A., DeLucas, L.J., Luo, M., Prestegard, Rose. J.P. and Wang, B.C. “The southeast collaboratory for structural genomics; A high-throughput gene to structure factory”.  Acc. Chem. Res. 3:191-198. (2003)

2002

1.  Sha J, Zhou Z, Li J, Yin L, Yang H, Hu G, Luo M, Chan HC, Zhou K; Spermatogenesis study group. “Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays”. Mol Hum Reprod. 8:511-7. (2002)

2.  Li S, Finley J, Liu ZJ, Qiu SH, Chen H, Luan CH, Carson M, Tsao J, Johnson D, Lin G, Zhao J, Thomas W, Nagy LA, Sha B, DeLucas LJ, Wang BC, and Luo M. "Crystal structure of the cytoskeleton-associated protein (CAP-Gly) domain". J Biol Chem. 277:48596-48601 (2002) PMID: 12221106

3.  Ding, H.-T., H. Ren, Q. Chen, G. Fang, L.F. Li, R. Li, Z. Wang, X.-Y. Jia, Y.-H. Liang, M.-H. Hu, Y. Li, J.-C. Luo, X.-C. Gu, X.-D. Su, M. Luo and S.-Y. Lu. “Parallel cloning, expression, purification and crystallization of human proteins for structural genomics”. Acta Cryst. D58,:2102–2108 (2002).

4.  Lommer, B. S. and M. Luo. "Structural Plasticity in influenza virus protein NS2 (NEP)". J. Biol. Chem. 277:7108-7117. (2002)

2001

1.  Harris, A., F. Forouhar, S. Qiu, B. Sha, and M. Luo.  "The Crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein interfaces can rotate in the oligomeric structures of M1". Virol. 289:34-44(2001). PMID: 11601915

2. Watson, R.D., K.J. Lee, S. Qiu, M. Luo, H.R. Umphrey, R.B. Roer, and E. Spaziani. "Molecular cloning, expression and tissue distribution of Crustacean molt-inhibiting hormone". Amer. Zool. 41:407-417. (2001).

2000

1.  Green, T.J, S. Macpherson, S. Qiu, J. Lebowitz, G.W. Wertz, and M. Luo. “Study of the Assembly of Vesicular Stomatitis Virus N Protein: The Role of the P protein”. J. Virol. 74:9515-9524 (2000). PMID: 11000221

2.  Barnes, S., H. Kim, V. Darley-Usmar, R. Patel, J. Xu, B. Boersma and M. Luo. “Beyond ERα and ERß: Estrogen receptor binding is only part of the isoflavone story”. J. Nutr. 130:656S-657S. (2000).

3.  Hertzler, S., Luo, M., Lipton, H. L. “Mutation of predicted virion pit residues alters binding of Theiler's murine encephalomyelitis virus to BHK-21 cells”. J Virol. 74:1994-2004. (2000).

4.  Zhou, L., Y. Luo, Y. Wu, J. Tsao, and M. Luo. “Sialylation of the Host Receptor May Modulate the Entry of the Demyelinating Persistent Theiler’s Virus”. J. Virol. 74:1477-1485. (2000) PMID: 10627559

1999

1.  Kobasa, D., S. Kodihalli, M. Luo, M.R. Castrucci, I. Donatelli, Y. Suzuki, T. Suzuki, and Y. Kawaoka. "Amino acid residues contributing to the substrate specificity of the influenza A virus neuraminidase". J. Virol. 73:6743-6751. (1999)

2.  Chai, J.-J., M. Li, B.-R. Huang, Y. Luo, M. Luo, R.-C. Bi, and C.-H. He. “Crystallization and preliminary X-ray diffraction studies of human epidermal growth factor”. Acta Cryst. D56:62-63. (1999).

3.  Finley, J., V.R. Atigadda, F. Duarte, J.J. Zhao, W.J. Brouillette, G.M. Air and M. Luo. “Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site”. J. Mol. Biol. 293:1107-1119. (1999).

4. Atigadda, V. R., Brouillette, W. J., Duarte, F., Babu, Y. S., Bantia, S., Chand, P., Chu, N., Montgomery, J. A., Walsh, D. A., Sudbeck, E. A., Finley, J., Air, G. M., Luo, M., and Laver, G. W., “Hydrophobic Benzoic Acids as Inhibitors of Influenza Neuraminidase,” BioOrg. Med. Chem., 7: 2487-2497 (1999)

5. Atigadda, V. R., Duarte, F. Ali, S., Babu, Y. S., Bantia, S., Chand, P., Chu, N., Montgomery, J., Walsh, D. A., Sudbeck, E. A., Finley, J., Luo, M., Air, G. M., Laver, G. W., and Brouillette, W. J., “Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent,” J. Med. Chem., 42: 2332-2343 (1999).

6.  Brouillette, W. J., Atigadda, V. R., Luo, M., Air, G. M., Babu, Y. S., and Bantia, S., “Design of Benzoic Acid Inhibitors of Influenza Neuraminidase Containing a Cyclic Substitution for the N-Acetyl Grouping,” Bioorg. Med. Chem. Lett., 9: 1901-1906 (1999).

7.  Phillips, S.E., B. Sha, L. Topalof, Z. Xie, J.G. Alb, V.A., Klenchin, P. Swigart, S. Cockroft, T.F.J. Martin, M. Luo, and V.A. Bankaitis. “Yeast Sec14p deficient in phosphoatidylinositol transfer activity is functional in vivo”. Mol. Cell. 4:1-20. (1999).

8.   Harris, A., B. Sha, and M. Luo. “Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: an evolutionary link between negative-stranded RNA viruses and retroviruses”. J. Gen. Virol. 80:863-869. (1999).

9.  Luo, Y., S-C. Li, Y-T. Li, and M. Luo. “1.8 Å structures of the Leech intramolecular trans-sialidase complexes: Evidence of its enzymatic mechanism”. J. Mol. Biol. 285:323-332. (1999).

1998

1.  Finley, J. and M. Luo. “X-ray crystal structures of half the human papilloma virus E2 binding site: d(GACCGCGGTC)”. Nucleic Acids Research. 26:5719-5727. (1998)

2.  Chai, J.J., C. He, M. Li, L. Tang and M. Luo. “Crystal structure of carboxypeptidase A complexed with an inactivator in two crystal forms”. Prot. Engin. 11:841-845. (1998)

3.  Luo, Y., S-C. Li, M-Y. Chou, Y-T. Li, and M. Luo. “The crystal structure of an intramolecular trans-sialidase with a NeuAca2->3Gal specificity”. Structure. 6:521-530. (1998).

4.  Sha, B.D., S.E., Phillips, V.A. Bankitas, and M. Luo. “Crystal Structure of the Saccharomyces cerevisiae phosphatidylinositol transfer protein”. Nature. 391:506-510. (1998). PMID: 9461221

5.  Luo, Y., M-Y. Chou, S-C. Li, Y-T. Li, and M. Luo. “Crystallization and Preliminary X-ray Studies of Sialidase L from the Leech Macrobdella decora”. Acta Crystallographia. D54:111-113. (1998).

1997

1.  Wang, A., J. Forman-Kay, Y. Luo, M. Luo, Y.H. Chow, J. Plumb, J.D. Friesen, L.C. Tsui, H.H.Q. Heng, J.L. Woolford, Jr., and J. Hu. “Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the splicesome”. Human Mol. Gen. 6:2117-2126. (1997)

2. Sha, B.D., V. Bankitas, and M. Luo. “Crystallization and Preliminary X-ray crystallographic studies of a lipid transfer protein, SEC14, from yeast”. Acta Crystallogr. D53:784-786. (1997)

3.  Zhou, L., Green, T., Lipton, H.L. and Luo, M. “Role of Sialyloligosaccharide Binding in Theiler’s Virus Persistence”. J. Virol. 71:9701-9712. (1997) PMID: 9371636

4.   Luo, M., Air, G.M., and Brouillette, W. “Design of aromatic inhibitors of influenza virus neuraminidase”. J. Infec. Dis. 176 (suppl 1):S62-S65. (1997)

5.  Sha, B.D. and Luo, M. “Crystallization and preliminary X-ray crystallographic studies of type A influenza virus matrix protein M1”, Acta Crystallogr.  D53:458-460 (1997)

6.  Sudbeck, E. Jedrzejas, M. J., Singh, S., Brouillette, W., Air, M.G., Laver, W.G. and Luo, M. “Refined structures of influenza virus neuraminidase complexed with novel aromatic inhibitors”. J. Mol. Biol. 267:584-594. (1997)

7.  Sha, B.D. and Luo, M. “The Crystal Structure of a Bifunctional Membrane-RNA Binding Protein, Influenza Virus Matrix Protein”, Nature Structural Biology, 4:239-244, (1997). PMID: 9164466

1996

Luo, M., Toth, K.S., Zhou, L., Pritchard, A. and Lipton, H.L. "The Structure of a Highly Neurovirulent Theiler's Virus (GDVII) and Implications for Determinants of Viral Persistence".  Virol., 220:246-250, (1996)

1995

1.  Jedrzejas, M. J., Singh, S., Brouillette, W., Air, M.G. and Luo, M. "A Strategy for Theoretical Inhibition Constant, Ki, Calculations of Aromatic Inhibitors Designed On the Basis of the Active Site Structure of Influenza Virus Neuraminidase", Proteins: Structure, Function and Genetics. 23:264-277. (1995)

2.  Singh, S., Jedrzejas, M. J., Air, M.G., Luo, M., W. Graeme Laver and Brouillette, W., "Structure-Based Inhibitors of Influenza Viral Neuraminidase. A Benzoic Acid Lead with Novel Interaction". J. Med. Chem. 34(10):3144-51, (1995).

3.  Zhou, L. and Luo, M. "Preliminary Analysis of Feline Calicivirus Crystals", Acta Crystallogr. D51:850-852, (1995).

4.  Jedrzejas, M.J., Baker, J.R., and Luo, M. "Crystallization and Preliminary X-ray Diffraction Studies of the Cartilage Link Protein from Bovine Trachea", Proteins: Structure, Function and Genetics. 22:76-78. (1995)

5.  Luo, M., Jedrzejas, M. J., White, C., Singh, S., Brouillette, W., Air, M.G., Laver, W.G. and Vasella, A. "Benzoic Acid Inhibitors of Influenza Virus Neuraminidase". Acta Crystallogr. D51:504-510, (1995)

6.  Jedrzejas,  M. J., Miglieta,  J., Griffin,  J. A.  and  Luo,  M.  "The  Structure  of  an  Anti-ICAM-1 Antibody, R6.5, Fab Fragment at 2.8 Å Resolution". Acta Crystallogr. D51, 380-385. (1995)

7.  Jedrzejas, M. J., Singh, S., Brouillette, W., Air, M.G. and Luo, M. "Structure of 4-(Acetylamino)-3-hydroxy-5-nitrobenzoic Acid". Acta Crystalllogr. C51:1910-1912, (1995).

8.  Jedrzejas, M. J., Singh, S., Brouillette, W., Air, M.G., Laver, W.G. and Luo, M. "Structure of Aromatic Inhibitors of Influenza Virus Neuraminidase", Biochemistry, 34:3144-3151 (1995). PMID: 7880809

9.  White, C., Janakiraman, M.N., Laver, W.G., Philippon, C., Vasella, J., Air, M.G. and Luo, M. "A Sialic Acid-derived Phosphonate Analog Inhibits Different Strains of Influenza Virus Neuraminidase with Different Efficiencies”. J. Mol. Biol. 245:623-634 (1995)

1994

1.  Zhou, L., Yu, QingZhong and Luo, Ming. "Characterization of Two Density Populations of Feline Calicivirus Particles". Virology, 205:530-      533, (1994).

2.  Janakiraman, M.N., White, C.L, Laver, W.G., Air, G. and Luo, M. "The Structure of B/Lee/40 Influenza Virus Neuraminidase Complexed with Two Neuraminic Acids at  1.8 Å Resolution: Implications for the Catalytic Mechanism". Biochemistry, 33:8172-8179, (1994)

3.  Ansardi, D.C., Luo, M. and Morrow, C.D. "Mutations in the Poliovirus P1 Capsid Precursor at Arginine Residues VP4-ARG34, VP3-ARG223, and VP1-ARG129 Affect Virus Assembly and Encapsidation of Genomic RNA". Virology, 119:20-34, (1994)

1993

Toth, K.S., Zhang, C.X., Lipton, H.L. and Luo, M. "Crystallization and Preliminary X-ray Diffraction Studies of Theiler's Virus (GDVII strain)". J. of Mol Biol. 231:1126-1129, (1993)

1992

1.  Mann, L.M., Anderson, K., Luo, M. and Bond, C.W. "Molecular and Structural Basis of Hemagglutination in Mengovirus". Virology, 190:337-345, (1992)

2.  Luo, M., Zhang, C.X., Toth, D.W. and Lipton, H.L. "Addition of β-Mercaptoethanol Produced Stable Crystals of Theiler's Virus". Crystal Growth, 119:407-411, (1992)

3.  Luo, M., Laver, W.G. and Air, G.M. "Unusual Diffraction of Type B Influenza Virus Neuraminidase Crystals". Acta Crystallogr., A48:263-266, (1992)

4.  Luo, M., He, C.H., Zhang, C.X., Toth, K. S. and Lipton, H.L. "The Atomic Structure of Theiler's murine encephalomyelitis Virus (BeAn strain)". Proc. Natl. Acad. Sci., 89:2409-2413, (1992). PMID: 8659122

 1991

1.  Jablonski, A.S., Luo, M. and Morrow, C.D. "Enzymatic Activity of Poliovirus RNA Polymerase Mutants with Single Amino Acid Changes in the Conserved YGDD Amino Acid Motif". J. of Virology, 65:4565-4562 (1991).

2.  Tsao, J., Chapman, M.S., Agbandje, M., Keller, W., Smith, K., Wu, H., Luo, M., Smith, T.J., Rossmann, M.G, Compans, R.W. and  Parrish, C.R. "The Three-Dimensional Structure of Canine Parvovirus and Its Functional Implications". Science, 251:1456-1464 (1991). PMID: 2006420

 1990

1.  Laver, W.G., Air, G.M., Luo, M., Portner, A., Thompson, D. and Webster, R.G. "Crystal Structure of Influenza Virus Neuraminidase Complexed with Monoclonal Antibody Fab Fragments". IN: Use of X-ray Crystallography in the Design of Antiviral Agents. Laver, W.G. and Air, G.M. eds. Academic Press, Inc. (1990).

2.  Air, G.M., Laver, W.G., Luo, M., Stray, S.J., Legrone, G. and Webster, R.G. "Antigenic, Sequence, and Crystal Variation in Influenza B Neuraminidase". Virology, 177:578-587, (1990).

3.  Lin, Y., Luo, M., Laver, W.G., Air, G.M., Smith, C.D. and Webster, R.G. "New Crystalline Forms of Neuraminidase of Type B Human Influenza Virus". J. Mol. Biol., 214:639-640, (1990).

4.  Kim, S., Boege, U., Krishnaswamy, S., Minor, I., Smith, T. J., Luo, M., Scraba, D. G., Rossmann, M. G. “Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly”. Virol. 175: 176-190. (1990).

1989

1.  Air, G.M., Laver, W.G., Webster, R.G., Els, M.C. and Luo, M. "Antibody Recognition of the Influenza Virus Neuraminidase". Cold        Spring Harbor Symp. on Quant. Biol., LIV:247-255, (1989).

2.  Laver, W.G., Webster, R.G., Bossart, P.J., Luo, M. and Air, G.M. "Recognition of Protein Antigens by Antibodies: Crystal Structure of Antibody Fab Fragments Complexed with Influenza Virus Neuraminidase". IN: The Immune Response to Structurally Defined Proteins: The Lysozyme Model, ISBM 0-940030-27-6. Smith-Gill, S. and Sercarz, E., eds. Adeninne Press, 141-149, (1989)

3.  Boege, U., Cygler, M., Wengler, G., Dumas, P., Tsao, J., Luo, M., Smith, T.J. and Rossmann, M.G. "Sindbis Virus Core Protein Crystals". J. Mol. Biol., 208:79-82. (1989). PMID: 2769756

 1988

1.  Pevear D.C., Borkowski, J., Luo, M. and Lipton, H. "Sequence Comparison of a Highly Virulent and a Less Virulent Strain of Theiler's Virus. Amino Acid Differences on a Three-dimensional Model Identify the Location of Possible Immunogenic Sites". Annals of N.Y.A.S., 540:652-653, (1988).

2.  Laver, W.G., Luo, M., Bossart, P.J., Babu, Y.S., Smith, C., Accavitti, M.A., Tulloch, P.A. and Air, G.M. "Crystallization and Preliminary X-ray Analysis of Type B Influenza Virus Neuraminidase Complexed with Fab Fragments". Virology, 167:621-624, (1988)

3.  Luo, M., Rossmann, M.G. and Palmenberg, A.C. "Prediction of Three-dimensional Models for Foot-and-mouth Disease Virus and Hepatitis A Virus". Virology, 166:503-514, (1988).

4.  Pevear, D.C., Luo, M. and Lipton, H.L. "Three-dimensional Model of the Capsid Proteins of Two Biologically Different Theiler’s Virus Strains: Clustering of Amino Acid Differences Identifies Possible Locations of Immunogenic Sites on Virion". Proc. Natl. Acad. Sci., USA, 85:4496-4500, (1988).

5.  Badge, J., Minor, I., Kremer, M.J., Oliveria, M.A., Smith, T.J., Griffith, J.P., Guerin, D.M.A., Krishnaswamy, S., Luo, M., Rossmann, M.G., McKinlay, M. A., Diana, G.D., Dutko, F.J., Fancher, M., Rueckert, R.R. and Heinz, B.A. "Structural Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14". Proc. Natl. Acad. Sci., USA, 85:3304-3308, (1988). PMID: 2835768

6.  Luo, M., Tsao, J., Rossmann, M.G., Basak, S. and Compans, R.W. "Preliminary X-ray Crystallographic Analysis of Canine Parvovirus Crystals". J. Mol. Biol., 200:209-211, (1988). PMID: 3379641

1987

1.  Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E. and Rossmann, M.G. "Structure Determination of Mengo Virus". Acta Crystallogr., B45:85-92, (1987).

2.  Blaas, D., Keuchler, E., Vriend, G., Arnold, E., Luo, M. and Rossmann, M.G. "Comparison of the Three-dimensional Structure of Two Human Rhinoviruses (HRV2 and HRV14)". Proteins: structure, function and genetics, 2:263-272, (1987).

3.  Rossmann, M.G., Arnold, E., Griffith, J.P., Kamer, G., Luo, M., Smith, T.J., Vriend, G., Rueckert, R.R., Sherry, B., McKinlay, M.A., Diana, G.D. and Otto, M.J. "Common Cold Viruses". TIBS,  12:313-317, (1987).

4.  Arnold, E., Vriend, G., Luo, M., Griffith, J.P., Kamer, G., Erickson, J.W., Johnson, J.E. and Rossmann, M.G. "The Structure Determination of a Common Cold Virus, Human Rhinovirus 14". Acta Crystallogr., A43:346-361, (1987).

5.  Rossmann, M.G., Arnold, E. Kamer, G., Kremer, M.J., Luo, M., Smith, T.J., Vriend, G., Rueckert, R.R., Mosser, A.G., Sherry, B., Boege, U., Scraba, D.G., McKinlay, M.A. and Diana, G.D. "Structure and Function of Human Rhinovirus 14 and Mengo Virus Neutralizing Antigenic Sites, Putative Receptor Binding Site, Neutralization by Drug Binding". IN: Positive Strand RNA Viruses. Brinton, M.A. and Rueckert, R.R., eds. Alan R. Liss, New York, 59-77, (1987)

6.  Luo, M., Vriend, G., Kamer, G., Minor, I., Arnold, E., Rossmann, M.G., Boege, U., Scraba, D.G., Duke, G.M. and Palmenberg, A.C. "The Atomic Structure of Mengo Virus at 3.0 Å Resolution". Science, 235:182-191, (1987). PMID: 3026048

7.  Arnold, E., Luo, M., Vriend, G., Rossmann, M.G., Palmenberg, A.C., Parks, G.D., Nicklin, M.J.H. and Wimmer, E. "Implications of the Picornavirus Capsid Structure for polyprotein Processing". Proc. Natl. Acad. Sci. USA, 84:21-25, (1987)

1986

1.  Rossmann, M.G., Arnold, E., Erickson, J.W., Frankenberger, E.A., Griffith, J.P., Hecht, H.J., Johnson, J.E., Kamer, G., Luo, M., Mosser, A.G., Rueckert, R.R., Sherry, B. and Vriend, G. "Structure of a Human Common Cold Virus (Rhinovirud 14) and Its Functional Relationship to Other Picornaviruses". IN: Molecular Biology of the Positive-Strand RNA Viruses. Rowlands, B.J., Maky, B.W.J. and Mayo, M.A., eds. Academic Press, London, 301-320, (1986).

2.  Smith, T.J., Kremer, M.J., Luo, M., Vriend, G., Arnold, E., Kamer, G., Rossmann, M.G., McKinlay, M.A., Diana, G.D. and Otto, M.J. "The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating". Science, 233:1286-1293, (1986). PMID: 3018924

3.  Vriend, G., Rossmann, M.G., Arnold, E., Luo, M., Griffith, J.P. and Moffat, K. "Post-refinement of Oscillation Diffraction Data Collected at a Synchrotron Radiation Source". J. Appl. Crystallogr., 19:134-139, (1986).

1985

Rossmann, M.G., Arnold, E., Erickson, J.W., Frankenberger, E.A.,Griffith, J.P., Hecht, H.J., Johnson, J.E., Kamer, G., Luo, M., Mosser, A.G., Rueckert, R.R., Sherry, B. and Vriend, G. "Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses". Nature (London), 317:145-153, (1985). PMID: 2993920

1984

1.  Luo, M., Arnold, E., Erickson, J.W., Rossmann, M.G., Boege, U. and Scraba, D.G. "Picornaviruses of Two Different Genera Have Similar Structures". J. Mol. Biol., 180:703-714, (1984).

2.  Arnold, E., Erickson, J.W., Fout, G.S., Frankenberger, E.A., Hecht, H.J., Luo, M., Rossmann, M.G. and Rueckert, R.R. " Virion Orientation in Cubic Crystals of the Human Common Cold Virus14". J. Mol. Biol., 177:417-430, (1984)

 

Book

Rossmann MG, Arnold E, Erickson JW, Frankenberger EA, Griffith JP, Hecht H-J, Johnson JE, Kamer G, Luo M, Mosser AG, Rueckert RR, Sherry B, and Vriend G. “The structure of a human common cold virus (Rhinovirus 14) and its functional relations to other picornaviruses”. 1987. p86-99. in Biological Organization: Macromolecular Interactions at High Resolution. Eds: Burnett RM and Vogel HJ. Academic Press, Orlando.

Rossmann MG, Arnold E, Erickson JW, Frankenberger EA, Griffith JP, Hecht H-J, Johnson JE, Kamer G, Luo M, Mosser AG, Rueckert RR, Sherry B, and Vriend G. “The structure of a human common cold virus (Rhinovirus 14) and its functional relations to other picornaviruses and plant viruses”. 1987. p301-320. in The Molecular Biology of the Positive Strand RNA Viruses. Eds: Rowlands DJ, Mayo MA and Mathy BWJ. Academic Press, Orlando.

Laver WG, Webster RG, Bossart PJ, Luo M and Air GM. “Recognition of protein antigens by antibodies: Crystal structure of antibody Fab fragments complexed with influenza virus neuraminidase”. 1989. p141-150. Eds: Smith-Gill SJ and Sercarz EE. Adenine Press, Schenectady.

Laver WG, Air, GM, Luo M, Portner A, ThompsonSD and Webster RG. “Crystal structures of influenza virus neuraminidase complexed with monoclonal antibody Fab fragments”. 1990. p49-60. in Use of X-ray crystallography in the design of antiviral agents. Eds: Laver WG and Air GM. Academic Press, San Diego.

Luo, M. "Virus Structure: Atomic Structure". 1995. p 1571-1573.  in Encyclopedia of Virology. Eds: Granoff and Webster R. Academic Press,

Luo, M. “Virus Assembly: Nonenveloped”. 2008.p200-204.  In Encyclopedia of Virology.  Eds: B.W.J. Mahy & M. van Regenmortel. Academic Press.

Luo, M. “Design of New Drugs Based on Protein Structure”. 1997. p43-49 in Biotechnology International. Eds: Fox and Connor, Universal Medical Press, San Francisco.

Chen Y, Qiu S, Luan C-H and Luo M. “A high throughput platform for eukaryotic proteins”. 2008. p209-220. in Structural Proteomics: High-throughput methods. Eds: Kobe B, Guss M and Huber T. Humana Press, Totowa.

Luo M, Green TJ and Zhou ZH. “Assembly of vesicular stomatitis virus”. 2011. p175-192. in Negative strand RNA virus. Ed: Luo M. World Scientific Publishing, Singapore.

Luo M. “Influenza virus entry”. 2012. p201-222. in Advances in Experimental Medicine and Biology 726: Viral Molecular Machines. Eds: Rossmann MG and Rao VB. Springer, New York.

 Luo M. “Negative Strand RNA Virus”. 2011. World Scientific Publishing, Singapore.