Congratulations to Jingyi Zhao for his paper published on JACS
Congratulations to Jingyi Zhao for his paper published on JACS. Recently, Prof. Jing Zhao and Prof. Peng Chen in PKU CCME have developed a photoactivable firefly luciferase based on photocaged unnatural amino acid. They replaced an important lysine residue with a genetically encoded photocaged lysine analog that would block the substrate binding in the enzyme's active site, and restore the activity of the luciferase with a low does UV laser. This work is published on JACS, named <Mechanism-Based Design of a Photoactivatable Firefly Luciferase>.