Huang Group
School of Chemical Biology & Biotechnology

德州大学圣安东尼奥分校Michael P. Doyle教授到访我院

时间:2018-06-16

       2018年6月13日,德州大学圣安东尼奥分校Michael P. Doyle教授应黄湧教授邀请到访我院,于E-104为我院师生举行了题为“Asymmetric Catalytic Constructions of Heterocycles and Carbocycles by Cycloaddition”的主题讲座。

      首先Doyle教授简略介绍了亲电金属卡宾反应的发展以及金属卡宾的反应机理,引出金属卡宾催化的环加成反应。接着Doyle教授呈现了他们发展的一系列通过金属卡宾催化不对称合成碳环和杂环的反应。例如:[3+3]、[3+2]、[3+1]等的环加成反应。这一系列反应可以通过烯醇重氮乙酸酯先与金属形成金属卡宾偶极子,再与另外一分子相应的化合物环加成构建。

      讲座结束之后,大家踊跃提问。随后,Doyle教授与同学们进行午餐座谈。座谈会中Doyle教授不仅为同学们解答在科研上遇见的一些问题,同时也给同学们介绍美国科研生活现状,并鼓励同学们跟着自己的科研兴趣,持之以恒,使同学们受益匪浅。(文字/李恩; 图片/李恩)

主讲人简介:

受教育经历:先后于圣托马斯大学、爱荷华州立大学取得学士、博士学位。

职业经历:先后执教于霍普学院、三一学院、亚利桑那大学、马里兰大学帕克分校、德克萨斯大学圣安东尼奥分校,现为德克萨斯大学圣安东尼奥分校教授。

研究兴趣:催化氧化过程、手机新催化剂的设计和发展、重氮化学、高对映选择性催化反应、药物化学。

 

Prof. Michael P. Doyle from University of Texas at San Antonio visited SCBB

       On June 13, 2018, with the invitation of Prof. Huang Yong, Prof. Michael P. Doyle from University of Texas at San Antonio visited our school and gave a wonderful lecture titled “Asymmetric Catalytic Constructions of Heterocycles and Carbocycles by Cycloaddition”in E104, teachers and students of our school actively participated in the academic discussions and exchanged ideas.

       Firstly, Prof. Doyle introduced historical scope of electrophilic metal carbene reactions and the basic mechanism for metal carbine reactions. Then, Prof. Doyle showed a series of cycloaddition reactions, which developed by their lab, via metal carbene to asymmetrically synthesize heterocycles and carbocycles. Such as, [3+3], [3+2], [3+1]-cycloaddition, etc. These cycloaddition reactions between can be constructed from dipole of metal carbene, which generated from enoldiazoacetates react with metal compound, with another corresponding compound.

       After the speech, professors and students of our school discussed with Prof. Doyle actively. Then, Prof. Doyle then had a lunch meeting with students. In the symposium, Prof. Doyle not only answered the students some problems about the chemical research, also introduced the scientific life in the USA to students, and encouraged the students to follow their own research interests and preserve in it , which made the students benefit a lot.(Written by En Li;Photoed by En Li)

Brief introduction of speaker:

Education:

Ph. D. in Chemistry; Iowa State University;

B. S. in Chemistry; College of St. Thomas.

Professional associations:

Prof. Doyle, the Rita and John Feik Distinguished University Chair in Medicinal Chemistry at the University of Texas at San Antonio, has had academic appointments at undergraduate institutions (Hope College and Trinity University) and graduate universities (University of Arizona and University of Maryland), as well as being Vice President, then President, of a science foundation before taking his current position.

Current research interests:

Catalytic oxidation processes

Design and development of chiral catalysts

Diazo chemistry

Highly enantioselective catalytic reactions

Medicinal chemistry