Congratulate Guiyong Wu’s paper published in Green Chem.

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

Guiyong Wu, Weiyu Yin, Hong C. Shen, and Yong Huang*.

Green. Chem., 2012, 14, 580-585 (cover).

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a “green” mild and highly efficient one-pot triple cascade was developed involving a Claisen–decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen–decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion.