Huang Group
School of Chemical Biology & Biotechnology

Qian Shao’s work has been published in Chem. Commun.!


Direct Fluorination of Styrenes

Qian Shao, and Yong Huang*, Chem. Commun. 201551, 6584-6586.

We have developed a practical method to synthesize fluorostyrene compounds. A mild and regioselective mono-fluorination reaction occurred smoothly for various di- and trisubstituted styrenes in the presence of RuCl3 and N-fluorobenzenesulfonimide (NFSI). A tandem alkyne hydroarylation–olefin fluorination reaction was also developed using an Au catalyst.