Li group published article on Journal of Materials Chemistry B about a study of organosilicon modification enhanced the stability of black phosphorus nanosheets at ambient conditions

Thanks to its tunable direct-bandgap, high charge-carrier mobility and unique in-plane anisotropic structure, black phosphorus (BP) has become a rising star of post-graphene two-dimensional (2D) nanomaterials. However, BP is unstable in the ambient conditions which largely limits its application....

Li group published article on Chemical Communication about a study of N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

The N-methylation effects on CIH peptides’ biophysical properties were systematically studied. The N-methylation at the N terminal NH could help improve the peptides’ cellular uptakes with retained helical conformation. This Nmethylation strategy could also be applied to longer peptides...

Li group published article on Journal of Medicinal Chemistry about a study of structural basis of inhibition of ERα-coactivator interaction by high affinity N‑terminus isoaspartic acid tethered he...

Direct inhibition of the protein−protein interaction of ERα and its endogenous coactivators with a cell permeable stabilized peptide may offer a novel, promising strategy for combating ERα positive breast cancers. Here, we report the cocrystal structure of a helical...

Li group published article on Theranostics about a study of In-tether chiral center induced helical peptide modulators target p53-MDM2/MDMX and inhibit tumor growth in stem-like cancer cell

Inhibition of the interaction between p53 and MDM2/MDMX has attracted significant attention in anticancer therapy development. We designed a series of in-tether chiral center-induced helical stabilized peptides, among which MeR/PhR effectively reactivated p53. The activation of p53 inhibits cell....

Li group published article on Chembiochem about a study of effect of stapling architecture on physiochemical properties and cell permeability of stapled – helical peptides

Stapled peptides emerged as a new class of targeting molecules of high binding affinity and specificity for intracellular undruggable targets. Their ability to penetrate cell membranes were exceptionally intriguing to the field, yet elusively and controversially discussed. To understand...

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