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1-s2.0-S1001841717302395-fx1A chirality induced helicity method has been developed to modulate the peptide’s biophysical and biochemical properties. We report herein a novel approach for reversibly switching the conformation of short constraint α-helical peptides through alkylation of the in-tether thioether and dealkylation of the chiral sulfonium. This traceless redox sensitive tagging strategy broadened our scope of CIH (chirality induced helicity) strategy and provided a valuable approach to functionalize the peptide tether

Link: http://www.sciencedirect.com/science/article/pii/S1001841717302395

时间 17/07/2017 at 20:14 作者 lizg