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The N-methylation effects on CIH peptides’ biophysical properties were systematically studied. The N-methylation at the N terminal NH could help improve the peptides’ cellular uptakes with retained helical conformation. This Nmethylation strategy could also be applied to longer peptides to improve their stability and cellular uptakes.

Link:http://pubs.rsc.org/en/content/articlepdf/2014/CC/C7CC09201F?page=search

 

时间 23/01/2018 at 20:30 作者 lizg