Proteomic Study Reveals the Involvement of Energy Metabolism in the

Rahman, Shafiq Ur et al. “Proteomic Study Reveals the Involvement of Energy Metabolism in the Fast Antidepressant Effect of (2R, 6R)-Hydroxy Norketamine.”  Clinical applications, e1900094. 21 Feb. 2020, doi:10.1002/prca.201900094

抑郁症是一种严重的精神疾病，在世界范围内造成严重的经济负担和社会后果。近年来，氯胺酮的代谢物(2R, 6R)-hydroxynorketamine (HNK)通过NMDA拮抗独立机制显示出较强的抗抑郁作用。本文比较了与NMDA拮抗剂MK-801相比，HNK可能参与不同治疗效果的细胞内分子和通路的机制。