At PKUSZ
#Equal contribution; *Correspondence.
22. Chen, Y.#; Zhang, L.#; Fang, L.#; Chen, C.; Zhang, D.; Peng, T.*, Modular development of enzyme-activatable proteolysis targeting chimeras for selective protein degradation and cancer targeting. JACS Au 2024, ASAP, doi: 10.1021/jacsau.4c00298. (Featured as the front cover.) Link.
21. Xu, Y.; Ding, K.; Peng, T.*, Chemical proteomics reveals Nε-fatty-acylation of septins by Rho Inactivation Domain (RID) of the Vibrio MARTX toxin to alter septin localization and organization. Mol. Cell. Proteomics 2024, 23, 100730. Link.
20. Zhang, Y.#; Du, Y.#; Liao, K.#; Peng, T.*, Modular development of organelle-targeting fluorescent probes for imaging formaldehyde in live cells. Anal. Methods 2024, 16, 3646−3653. (Featured as the front cover.) Link.
19. Peng, T.*; Das, T.; Ding, K.; Hang, H. C., Functional analysis of protein post-translational modifications using genetic codon expansion. Protein Sci. 2023, 32, e4618. Link.
18. Li, M.; Peng, T.*, Genetic Encoding of a fluorescent noncanonical amino acid as a FRET donor for the analysis of deubiquitinase activities. In Genetically Incorporated Non-Canonical Amino Acids: Methods and Protocols; Tsai, Y.-H., Elsässer, S. J., Eds.; Springer US: New York, NY, 2023; pp 55−67. Link.
17. Li, M.; Wang, F.; Yan, L.; Lu, M.; Zhang, Y.; Peng, T.*, Genetically encoded fluorescent unnatural amino acids and FRET probes for detecting deubiquitinase activities. Chem. Commun. 2022, 58, 10186–10189. Link.
16. Sun, Y.#; Chen, Y.#; Xu, Y.; Zhang, Y.; Lu, M.; Li, M.; Zhou, L.; Peng, T.* Genetic Encoding of ε-N-L-Lactyllysine for Detecting Delactylase Activity in Living Cells. Chem. Commun. 2022, 58, 8544-8547. Link.
15. Sun, Y.#; Chen, Y.#; Peng, T.* A Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation. Chem. Sci. 2022, 13, 6019-6027. Link.
14. Yao, L.; Rong, Y.; Ma, X.; Li, H.; Deng, D.; Chen, Y.; Yang, S.; Peng, T.; Ye, T.; Liang, F.; Xu, N.; Zhou, Q.* Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons. J. Neurosci. 2022, 42, 3066-3079. Link.
13. Zhang, D.#; Lu, M.#; Chen, C.; Xu, Y.; Peng, T.* Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. ChemBioChem 2022, 23, e202100628. Link.
12. Du, Y.#; Zhang, Y.#; Huang, M.#; Wang, S.; Wang, J.; Liao, K.; Wu, X.; Zhou, Q.; Zhang, X.; Wu, Y.-D.*; Peng, T.* Systematic Investigation of the aza-Cope Reaction for Fluorescence Imaging of Formaldehyde in Vitro and in Vivo. Chem. Sci. 2021, 12, 13857-13869. Link.
11. Garst, E. H.; Lee, H.; Das, T.; Bhattacharya, S.; Percher, A.; Wiewiora, R.; Witte, I. P.; Li, Y.; Peng, T.; Im, W.; Hang, H. C*. Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity. ACS Chem. Biol. 2021, 16, 844-856. Link.
10. Wang, S.#; Wu, X.#; Zhang, Y.; Zhang, D.; Xie, B.; Pan, Z.; Ouyang, K.; Peng, T.* Discovery of a Highly Efficient Nitroaryl Group for Detection of Nitroreductase and Imaging of Hypoxic Tumor Cells. Org. Biomol. Chem. 2021, 19, 3469-3478. Link.
9. Li, Y.#; Wang, S.#; Chen, Y.; Li, M.; Dong, X.; Hang, H. C.*; Peng, T.* Site-Specific Chemical Fatty-Acylation for Gain-of-Function Analysis of Protein S-Palmitoylation in Live Cells. Chem. Commun. 2020, 56, 13880-13883. Link.
8. Chen, C.; Peng, T.* Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells. STAR Protocols 2020, 1, 100109. Link.
7. Zhang, Y.#; Du, Y.#; Li, M.; Zhang, D.; Xiang, Z.; Peng, T.* Activity-Based Genetically Encoded Fluorescent and Luminescent Probes for Detecting Formaldehyde in Living Cells. Angew. Chem. Int. Ed. 2020, 59, 16352-16356. Link.
6. Wu, X.; Spence, J. S.; Das, T.; Yuan, X.; Chen, C.; Zhang, Y.; Li, Y.; Sun, Y.; Chandran, K.; Hang, H. C.*; Peng, T.* Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase. Cell Chem. Biol. 2020, 27, 571-585.e576. Link.
5. Zhang, Z. J.; Pedicord, V. A.; Peng, T.; Hang, H. C.* Site-Specific Acylation of a Bacterial Virulence Regulator Attenuates Infection. Nat. Chem. Biol. 2020, 16, 95-103. Link.
4. Spence, J. S.#; He, R.#; Hoffmann, H.-H.; Das, T.; Thinon, E.; Rice, C. M.; Peng, T.*; Chandran, K.*; Hang, H. C.* IFITM3 Directly Engages and Shuttles Incoming Virus Particles to Lysosomes. Nat. Chem. Biol. 2019, 15, 259-268. Link.
3. Peng, T.*; Hang, H. C.*: Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens. In Activity-Based Protein Profiling; Cravatt, B. F., Hsu, K.-L., Weerapana, E., Eds.; Springer International Publishing: Cham, 2019; pp 93-110. Link.
2. Liu, W.#; Zhou, Y.#; Peng, T.#; Zhou, P.; Ding, X.; Li, Z.; Zhong, H.; Xu, Y.; Chen, S.; Hang, H. C.*; Shao, F.* Nε-Fatty Acylation of Multiple Membrane-associated Proteins by Shigella IcsB Effector to Modulate Host Function. Nat. Microbiol. 2018, 3, 996-1009. Link.
1. Peng, T.*; Hang, H. C.* Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. J. Am. Chem. Soc. 2016, 138, 14423-14433. Link.
Prior to PKUSZ
Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K*. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Mol Cell. 2019 Apr 4;74(1):45-58.e7.
Peng T, Chen X, Gao L, Zhang T, Wang W, Shen J, Yang D. A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues. Chem Sci. 2016 Apr;7:5407-13.
Peng T, Thinon E, Hang HC. Proteomic analysis of fatty-acylated proteins. Curr Opin Chem Biol. 2016 Feb;30:77-86.
Gao L, Chen X, Peng T, Yang D, Wang Q, Lv Z, Shen J. Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free Radic Biol Med. 2016 Jun;95:209-15.
Peng T, Hang HC. Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells. J Am Chem Soc. 2015 Jan 21;137(2):556-9.
Santiago-Tirado FH, Peng T, Yang M, Hang HC, Doering TL. A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathog. 2015 May 13;11(5):e1004908.
Burnaevskiy N, Peng T, Reddick LE, Hang HC, Alto NM. Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ. Mol Cell. 2015 Apr 2;58(1):110-22.
Liu Z, Yang T, Li X, Peng T, Hang HC, Li XD. Integrative chemical biology approaches for identification and characterization of “erasers” for fatty-acid-acylated lysine residues within proteins. Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1149-52.
Di Tomo P, Di Silvestre S, Cordone VG, Giardinelli A, Faricelli B, Pipino C, Lanuti P, Peng T, Formoso G, Yang D, Arduini A, Chiarelli F, Pandolfi A, Di Pietro N. Centella Asiatica and Lipoic Acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women. Nutr Metab Cardiovasc Dis. 2015 Jul;25(7):659-66.
Peng T, Hang HC. SORTing out cellular proteomes in vivo. Nat Biotechnol. 2014 May;32(5):445-6.
Peng T, Wong NK, Chen X, Chan YK, Ho DH, Sun Z, Hu JJ, Shen J, El-Nezami H, Yang D. Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues. J Am Chem Soc. 2014 Aug 20;136(33):11728-34.
Peng T, Yuan X, Hang HC. Turning the spotlight on protein-lipid interactions in cells. Curr Opin Chem Biol. 2014 Aug;21:144-53.
Xu M, Chen X, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu K, Shen J. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2013 Oct 28;150(1):116-24
Ieda N, Nakagawa H, Peng T, Yang D, Suzuki T, Miyata N. Photo-controllable peroxynitrite generator based on N-methyl-N-nitrosoaminophenol for cellular application. J Am Chem Soc. 2012 Feb 8;134(5):2563-8.
Ieda N, Nakagawa H, Horinouchi T, Peng T, Yang D, Tsumoto H, Suzuki T, Fukuhara K, Miyata N. Peroxynitrite generation from NO-releasing nitrobenzene derivative in response to photoirradiation. Chem Commun (Camb). 2011 Jun 14;47(22):6449-51.
Peng T, Yang D. HKGreen-3: a rhodol-based fluorescent probe for peroxynitrite. Org Lett. 2010 Nov 5;12(21):4932-5.
Peng T, Yang D. Construction of a library of rhodol fluorophores for developing new fluorescent probes. Org Lett. 2010 Feb 5;12(3):496-9.
Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PK. Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells. Methods Mol Biol. 2010;591:93-103.