我们课题组以“化学生物学”为核心研究方向，聚焦于化学工具与生物体系的交叉前沿，旨在通过化学工具揭示生命和疾病过程并推动药物研发。研究工作主要涵盖以下几个方面：

（1）有机与生物正交化学：针对生物分子的特异性检测和动态标记，发展高效、选择性的化学反应策略，为开发可激活探针和化学探针奠定基础，为生命过程研究提供精准化学工具。

（2）可激活探针与分子成像：发展激活型光学探针，实现细胞和活体水平生物标志物的特异性成像与动态监测，助力生物过程的实时可视化。

（3）化学探针与蛋白质组学：基于化学探针结合蛋白质组学技术，解析蛋白质翻译后修饰、功能及其调控机制，推动新靶点的发现。

（4）生物学与药物发现：以化学工具为桥梁，开展疾病机制解析以及药物筛选与递送研究，探索从基础研究到临床前应用的转化途径。

通过有机合成、分析化学、生物化学、细胞生物学与蛋白质组学等跨学科整合，我们致力于推动化学与生物学的深度融合，发展新一代分子工具和治疗策略，为疾病诊断与治疗提供新的思路和解决方案。

Our lab’s research interests mainly lie in developing and applying chemical tools and approaches to elucidate fundamental mechanisms of human diseases and explore new therapeutic strategies. Both endogenous and exogenous metabolites, encompassing a broad range of small molecules from reactive species to fatty acids and hormones, have critical roles at all levels of biological complexity by affecting or regulating key physiological pathways. Abnormal metabolism of these active molecules has also been linked to a variety of human diseases. We are developing robust chemical tools and approaches to

(i) image key reactive metabolites,

(ii) globally profile the biochemical targets of metabolites,

(iii) study the biological functions of metabolite-targets in mammalian cells.

A better understanding of the pathophysiological functions of key metabolites will enable the identification of novel therapeutic targets and ultimately promote the development of new therapeutic drugs and strategies.

We employ multidisciplinary techniques from organic synthesis, biochemistry, cell biology, and proteomics to approach these important biological questions.