华中科技大学薛宇教授到访我院
9月25日上午10时许，应我院叶志强副教授邀请，来自华中科技大学生命科学学院的薛宇教授到访我院，并在F栋101会议室带来了题为“Computational Analysis of the Phosphoproteomic Data”的精彩报告。在报告中，薛教授详细阐释了自己的课题组多年来从事的蛋白质翻译后修饰，尤其是激酶催化的蛋白质磷酸化修饰的相关研究。激酶(kinase)是一类从高能供体分子（如ATP）转移磷酸基团到特定靶分子（底物）的酶，在人体中有大于500个成员，以调节细胞内的许多生理过程。激酶是超过75%的复杂疾病的潜药药物靶点，可见其重要性。薛教授团队通过经典的BLOSUM矩阵方法，建立了独创的GPS(Group-Based Prediction System)系统，用以预测蛋白质的哪个位点被哪个激酶所磷酸化。同时，薛教授团队也对重要的一类细胞周期调控因子Polo样激酶(Polo-Like Kinase)具体的磷酸化位点做了细致的预测。同时通过实验验证了人类Mis18B是一类和PLK1激酶相互作用的新型蛋白。薛教授在磷酸化蛋白质组学方面做出了较为重要的原创性贡献。
薛宇教授1998年本科就读于中国科技大学，获得高分子科学和计算机科学双学士学位。随后留校在中科大生科院，师从姚雪彪教授，于2006年获细胞生物学博士学位。07至09年担任中科大副教授，09年至今担任华中科大生科院教授。至今已经发表SCI论文50余篇，被引用超过1500次。2010年入选教育部“新世纪优秀人才支持计划”，2013年1月获“青年科学之星铜奖”，2014年担任中国生物工程学会计算生物学与生物信息学专业委员会的副主任委员，2015年入选“青年拔尖人才支持计划”。
Prof. XUE Yu visited SCBB and gave a report of Computational Analysis of the Phosphoproteomic Data
In the morning of September 25, 2015, with the invitation of Prof. YE Zhi-Qiang, Prof. XUE Yu from Huazhong University of Science and Technology, gave us a great academic report in F101 meeting room.
The title of Prof. Xue’s report is “Computational Analysis of the Phosphoproteomic Data”. Post-translational modification of proteins provides reversible means to regulate the function of a protein in space and time. Phosphorylation is the addition of a phosphate group to a protein or other organic molecule. Kinase is a type of enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates like proteins. Prof. Xue’s group has done good jobs in predicting the selectivity and relationships of the kinases and substrates of phosphorylations. In 2008, they developed the a GPS (Group-based Prediction System, http://gps.biocuckoo.org) algorithm, which can predict kinase-specific phosphorylation sites. Consequently, they further developed a software package of iGPS (“in vivo” GPS, http://igps.biocuckoo.org) for predicting potential site-specific kinase-substrate relations (ssKSRs) and re-constructing phosphorylation networks using the BLOSUM matrix. And some of these predictions have already been validated by some of the experimental foundings. Prof. Xue’s studies not only provided useful tool for analyzing the phosphoproteomic data, but also the prediction results are accurate for further experimental manipulation. Now Prof. Xue’s group members also do some experiments using yeast and do some kinase-activitty analysis to broaden the applications of their methods.
Prof. XUE Yu was born in Hefei in the year of 1980 and graduated from the university of Science & Technology (USTC) in 2002 with the Bachelor’s Degree of Polymer Chemistry Science and a double major Bachelor’s Degree of Computational Science. Then he earned his Ph.D. in life sciences from the same university under the supervision of Prof. YAO Xue-Biao. He was appointed as the associate professor in USTC from 2007 to 2009. He then moved to the School of Life Sciences in Huazhong University of Science & Technology to hold a position of full professor. He has published over 55 publications with a total citation of more than 1500 times. Prof. Xue has been awaded many honors including the “Trans-century Talent by the Ministry of Education”, “Young Scientific Elite” and “Top Young Innovative Talent” etc.