Dong-Yang Li

李东阳 Dong-Yang Li

Research Assoc. Prof.     (08/2015 ~ present)

Ph. D.   Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

School of Chemical Biology and Biotechnology

Peking University Shenzhen Graduate School

Room G-201B, Building G, SCBB, Peking University Campus,

University Town, Nanshan District,

Shenzhen, P.R. China. 518055

Tel:       86-0755-26033063

Email:   lidy at pkusz.edu.cn

Professional Experience                                                                                                                                                                

09/2013 – 01/2015         Shanghai ChemPartner, Shanghai, China

Associate Director, Head of Structural Biology, Biologics Department

01/2011 – 08/2013         Shanghai ChemPartner, Shanghai, China

Principal Scientist, Head of Structural Biology, Biologics Department

08/2010 – 12/2010         Shanghai ChemPartner, Shanghai, China

Senior Scientist, Group leader of Crystallography service, Biologics Department

5/2010 – 7/2010             Fudan University, Shanghai, China

Associate Professor, Shanghai Medical College

12/2006 – 2/2010           Brookhaven National Laboratory, Upton, NY

Postdoctoral Research Fellow, Biology Department

01/2003 – 11/2006        National Cancer Institute, NIH, Bethesda, MD

Postdoctoral Research Fellow, Laboratory of Cell biology

10/2002 – 01/2003        Shanghai Institute of Biochemistry and Cell Biology, CAS, Shanghai, China

Assistant Professor, Laboratory of Biotechnology and Applications

10/2001 – 9/2002         Shanghai Institute of Biochemistry and Cell Biology, CAS, Shanghai, China

Research Associate, Laboratory of Enzyme Engineering

9/1998 – 10/1999         Hong Kong University of Science and Technology, Hong Kong

Research Assistant, Department of Biochemistry

Education

9/1995 - 9/2001     Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences,

Degree:         Ph.D.

Major:           Biochemistry and Molecular Biology

9/1990 - 7/1994     China Pharmaceutical University, Nanjing, China

Degree:         Bachelor of Engineering

Major:           Biopharmaceutical Sciences

 Grant and Award：

7/2002 - 8/2005           National Natural Science Foundation of China, National Science for Youth Foundation (No. 30200002) (Project Leader)

Pubilications：

1. Dongyang Li, Hua Li, Tao Wang, Hong Pan, Gang Lin & Huilin Li. (2010). Structural basis for the assembly and gate closure mechanism of the Mycobacterium tuberculosis proteasome. EMBO J. 29, 2037-47
2. Gang Lin*, Dongyang Li*(Equally Contributed Authors), Luiz Pedro Sorio de Carvalho, Haiteng Deng, Hui Tao, Guillaume Vogt, Kangyun Wu, Jean Schneider, Tamutenda Chidawanyika, J. David Warren, Huilin Li & Carl Nathan. (2009). Inhibitors selective for mycobacterial versus human proteasomes. Nature 461, 621-626.
3. Wai-Kwan Tang, Dongyang Li, Chou-Chi Li, Lothar Esser, Renming Dai, Liang Guo & Di Xia. (2010). A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. EMBO J. 29, 2217-29
4. Gang Lin, Dongyang Li, Tamutend Chidawanyika, Carl Nathan & Huilin Li. (2010). Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Arch. Biochem. Biophys. 501, 214-20.
5. Tao Wang, Hua Li, Gang Lin, Chunyan Tang, Dongyang Li, Carl Nathan, Heran Darwin & Huilin Li. (2009). Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure 17, 1377-1385.
6. Pamela Osenkowski, Hua Li, Wenjuan Ye, Dongyang Li, Lorene Aeschbach, Patrick C. Fraering, Michael S. Wolfe, Dennis J. Selkoe & Huilin Li. (2009). Cryoelectron microscopy structure of purified gamma-secretase at 12 Å resolution. J. Mol. Biol. 385, 642-652.
7. Wai-Kwan Tang, Dongyang Li, Lothar Esser & Di Xia. (2009). Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65, 1166-1170.
8. Matthias Cacquevel, Lorene Aeschbach, Pamela Osenkowski, Wenjuan Yu, Dongyang Li, Michael S. Wolfe, Huilin Li, Dennis J. Selkoe & Patrick C. Fraering. (2008). Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer’s disease. J. Neurochem. 104, 210-220.
9. Lan Huang, Dongyang Li, Shaoxiao Wang, Shiming Zhang&, Junhui Chen & Xiangfu Wu. (2005). Cloning and identification of methionine synthase gene from Pichia pastoris. Acta Biochim. Biophys. Sin. 37, 371-378.
10. Zhiliang Yu, Xingjia Wu, Dongyang Li, Sheng Yang, Zheng Zhou, Jing Cai & Zhongyi Yuan. (2003). Enhancement of the production of SAM by overexpression of SAM synthetase in Pichia pastoris. Acta Biochim. Biophys. Sin. 35, 127-132.
11. Jian Yu, Dongyang Li, Yingjiu Zhang, Sheng Yang, Renbao Li & Zhongyi Yuan. (2002). High expression of Trigonopsis variabilis D-amino acid oxidase in Pichia pastoris. J. Mol. Catal., B Enzym. 18, 291-297.
12. Dongyang Li, Xingsong Ji, Jian Yu & Zhongyi Yuan. (2001). Cloning and functional analysis of the Pichia pastoris cystathionine beta-synthase gene, Acta Biochim. Biophys. Sin. 33, 600-606.
13. Dongyang Li, Jian Yu, Lu Tian, Xingsong Ji & Zhongyi Yuan. (2000). Production of SAM by recombinant Pichia pastoris. Chin. J. Biotechnol. 18, 295-299.
14. Jun Hang, Haifeng Shi, Dongyang Li, Yinglei Liao, Dejun Lian, Xiao, Y. & Hong Xue. (2000). Ligand binding and structural properties of segments of GABAA Receptor alpha 1 Subunit over-expressed in Escherichia coli. J. Biol. Chem. 275, 18818-18823.
15. Ruiai Chu, Fengqing Li, Dongyang Li, Mei Hong & Zhongyi Yuan. (1997). Production of L-sorbose using PVA-immobilized A. melanogerum. Chin. J. Biotechnol. 13, 214-216.

Patents：

1. Zhongyi Yuan, Dongyang Li and Xingsong Ji. A novel method to produce S-adenosyl-L-methionine, 2001, CN 02112087.0
2. Zhongyi Yuan, Dongyang Li, Jian Yu, and Sheng Yang. Construction and fermentation of a Pichia pastoris strain with high D-Amino Acid Oxidase expression level, 2001, CN. 01132380.9