NAME: LIHE,ZHANG (Li ho， CHANG )
Birth Day and Place: 8th Sept. 1937, Yang Zhou, Jiang Su
University Education :
1964-1967 Graduate School, Beijing Medical College, Major in Med. Chem.
1954-1958 Department of Pharmacy, Beijing Medical College, China
Professional Experience:
2006-date President, Academic Committee of School of Pharmaceutical Sciences，,
Peking University
2000- date Professor of Medicinal Chemistry, Peking University
1992-2006 Director, State Key Laboratory of Natural and Biomimetic Drugs, Peking University,
Beijing, China
1998-2006 Director, Chemistry Department, National Natural Science Foundation of China
1986-2000 Dean， Professor of Medicinal Chemistry, School of Pharmaceutical Sciences,
Beijing Medical University
1983-1986 Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University
1981-1983 Research Associate, Department of Chemistry, University of Virginia, USA
1967-1981 Lecturer, Department of Pharmacy, Beijing Medical College
1958-1964 Assistant, Department of Pharmacy, Beijing Medical College
Scientific Society & other committee activities:
Titular Member, IUPAC, Division III , Organic and Biomolecular Chemistry Committee ( 2006-2008) ;
Fellow, Royal Society of Chemistry, UK ( 2006-),
Vice-President, Chinese Pharmaceutical Association (1997-2001) ;
President, Asian Federation for Medicinal Chemistry (1998-2000)
Editorial Boards:
Member, Internat. Adv. Editorial Board, Organic & Biomolecular Chemistry (2006-) ,
ChemMedChem (2007-),
Medicinal Research Review (2004-),
Current Topics of Medicinal Chemistry (2000-)
Editor in Chief: Chinese Journal of Medicinal Chemistry
Vice Editor in Chief: Chemical Journal of Chinese Universities
Awards:
2009 Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan
2004 National Natural Science Award, Second Prize, Ministry of Science and Technology. China
2002 Science and Technology Award, Second Prize, awarded by The Ministry of Education, China
2000 Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA
1999 He-Liang-He-Li Prize
1998 Science and Technology Award, First Prize, awarded by The Ministry of Education, China
1996 Science and Technology Award, Second Prize, awarded by The Ministry of Education,China-
1995 Member, Chinese Academy of Sciences
1993 12th Edgar Snow Professorship, awarded by Edgar Snow Foundation and University of Missouri,
Kansas City , USA
1993 Colorcon Award, International Symposium of International Pharmaceutical Association, Tokyo, Japan
1990 Honorary Doctorate, Hoshi University, Japan
1988 Otani Prize, awarded by Hoshi University, Japan
1980 Beijing Science and Technology Prize, awarded by Beijing City Government, China
1964 National Award for Scientific Research Excellence, State Commission Science & Technology, China
Research Interests:Drug Discovery Based on Nucleosides and Nucleotides
Cyclic ADP-ribose ( cADPR ), a metabolite of NAD+, was discovered in 1987 and is a signaling molecule to regulate calcium mobilization via ryanodine receptors (RyR) from intracellular stores in a wide variety of biological systems. A main approach to explore the molecular mechanism of calcium release is to investigate the relationship of the structure of cADPR and cADPR analogues with their respective biological activities. In addition to the structure activity relationship, such studies result in novel antagonists and agonists which serve as the tools for mechanistic studies in the complex cellular system or potential. drug lead..
For the discovery of novel efficient way to modify oligonucleotide, a series of single isonucleotide incorporated antisense oligodeoxynucleotides and siRNA have been synthesized. This study indicated the possibility of designing a novel and effective antisense oligodeoxynucleotide and siRNA by incorporating an isonucleotide at the different positions of the sequence.
Selected Publications:
- 1. DM Zhou, LH Zhang, K. Taira. Explanation by the Double-Metal-Ion Mechanism of Catalysis for the Differential Metal Ion Effects on the Cleavage Rates of 5'-Oxy and 5'-Thio Substrates by a Hammerhead Ribozyme. Proc. Natl.Acad. Sci.USA , 1997, 94, 14343-14348.
- 2. Z Lei, L Zhang, LR Zhang, J Chen, JM Min, LH Zhang. Hybrid characteristics of oligonucleotides consisting of isonucleoside 2’, 5’-anhydro-3’-deoxy-3’-(thymin-1-yl)-D- mannitol with different linkage modes. Nucleic Acids Res., 2001, 29, 1470-1475.
- 3. J Chen, LR Zhang, JM Min, LH Zhang. Studies on the synthesis of a G-rich octaoligonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure. Nucleic Acids Res., 2002, 30, 3005-3014.
- 4. LJ Huang, YY Zhao, L Yuan, JM Min, LH Zhang. Synthesis and calcium mobilizing evaluations of N-1 glucosyl substituted cyclic inosine diphosphat as stable analogs of cADPR. J. Med. Chem., 2002, 45, 5340-5352
- 5. XF Gu, LR Zhang, ZJ Yang, HW Jin, Q Li, L Carrier, LH Zhang. A minimal structural analogue of cyclic ADP-ribose synthesis and calcium release activity in mammalian cells. J. Biol. Chem., 2005, 280, 15952-15959.
- 6. ZL Wang, JF Shi, HW Jin, LR Zhang, JF Lu, LH Zhang. Properties of isonucleotide- incorporated oligodeoxynucleotides and inhibition of the expression of spike protein of SARS-CoV. Bioconjugate Chem., 2005, 16, 1081-1087.
- 7. A. K.Y. Kwong, Z. Chen, H. M. Zhang, F. P. Leung, C. M. Ching Lam, K. Y. Ting, L. R. Zhang, Q. Hao, L. H. Zhang*, H. C. Lee. Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry, 2012, 51, 555-564.
- 8. Y. Zhou, K. Y. Ting, C. M. Ching Lam, A. K.Y. Kwong, J. Xia, H. W. Jin, Z. M. Liu, L. R. Zhang, H. C. Lee, L.H. Zhang, Design, synthesis and biological evaluation of novel non-covalent inhibitors of human CD38 NADase. ChemMedChem, 2012, 7, 223-228.
- 9. P.L. Yu, Z. H. Zhang, B.X. Hao, Y. J. Zhao, L. H. Zhang, H. C. Lee, L. R. Zhang, J. B. Yue, A novel fluorescent cell membrane permeable caged cyclic ADP-ribose analogue. J. Biol. Chem., 2012, 287, 24774-83.
- 10. Xin Jin, Tingting Sun, Chuanke Zhao, Yongxiang Zheng, Yufan Zhang, Weijing Cai, Qiuchen He, Kaz Taira, Lihe Zhang and Demin Zhou, Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA. Nucleic Acids Research, 2012,40(4), 1797-1806