Zhao Group
School of Chemical Biology & Biotechnology

Rh(Ⅲ)-Catalyzed Coupling of N-(pivaloyloxy)benzamides and Donor/Acceptor Diazo Compounds


(Reported by Rong Ben, April 21th, 2013)

Nitrogen-containing heterocycles are prevalent in drugs and natural products.  Recently, the Rovis’s Group developed a new approach to access isoindolones via Rh(III)-Catalyzed C−H Activation.


Mechanistic experiments suggested that C–H activation is turnover-limiting and irreversible.

J. Am. Chem. Soc.2013135 (14), 5364–5367.