Recapitulation of well-defined α-helices could result in constrained peptide mimetics with preferable secondary structures and enhanced therapeutic properties for various purposes. Among the helix-stabilizing strategies, the nucleation strategies are able to maximize recognition specificity of the original sequence without compromising the molecular recognition surface. In this review, current methodologies of helix nucleation are introduced including their constructing strategies, structure features and proof of concept biological applications.
Link: http://engine.scichina.com/publisher/scp/journal/SCC/doi/10.1007/s11426-016-9033-y?slug=abstract