发育与遗传学实验室
School of Chemical Biology & Biotechnology

Publications

41. Lu X, Liu Y, Yan G, et al. Optimized Target-AID system efficiently induces single base changes in zebrafish. J Genet Genomics. 2018 Mar 26. pii: S1673-8527(18)30046-8.

40. Yan G, Yan R, Chen C, et al. Engineering vascularized skeletal muscle tissue with transcriptional factor ETV2-induced autologous endothelial cells. Protein Cell, 2018 Apr 23.

39. Zhang Y, Qin W, Lu X, et al. Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. Nature Communications, 2017, 8.

38. Zhang Y, Huang H, Zhao G, et al. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS genetics, 2017, 13(2): e1006481.

37. Feng Y, Chen C, Han Y, Chen Z, Lu X, Liang F, Li S, Qin W, Lin S. Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. G3 (Bethesda). 2016 Aug 9;6(8):2517-21.

36. Fang Liang,Yuxiang Han,Hao Gao,Shengchang Xin,Shaodan Chen, Nan Wang,Wei Qin,Hanbing Zhong, Shuo Lin,Xinsheng Yao, Song Li,Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways,Scientific Reports.2015(5): 10.1038.

35. Wei Qin,Fang Liang,Yan Feng, Haipeng Bai, Ruibin Yan, Song Li,Shao Lin, Expansion of CRISPRCas9 genome targeting sites in zebrafish by Csy4-based RNA processing, Cell Research.(2015) 25:1074-1077.

34. Wei Qin, Zelin Chen,Yihan Zhang, Ruibin Yan,Guanrong Yan,Song Li,Hanbing Zhong, and Shuo Lin, Nom1 Mediates Pancreas Development by Regulating Ribosome Biogenesis in Zebrafish. PLoS One. 2014; 9(6): e100796.

33. Da Liu, Zhanxiang Wang, An Xiao, Yutian Zhang,Wenyuan Li, Yao Zu, Shaohua Yao, Shuo Lin,Bo Zhang, Efficient Gene Targeting in Zebrafish Mediated by a Zebrafish-Codon-Optimized Cas9 and Evaluation of Off-Targeting Effect. Journal of Genetics and Genomic ,2014,41(1)43-46.

32. ChaoChe,Bo Yang,Xianlong Jiang,Taofeng Shao,Zhixiong Yu,Chuanye Tao,Song Li,ShuoLin.,Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-annulation. J Org Chem. 2014 ,79(1):436-40.

31. Zhidan Xia Xiangjun Tong Fang Liang Yihan Zhang Chikin Kuok Yingla Zhang Xinxing Liu Zuoyan Zhu Shuo Lin Bo Zhang.,Eif3ba regulates cranial neural crest development by modulating p53 in zebra fish. Dev Biol. 2013, 381(1)83-96.

30. Guiqi Ren, Song Li, Hanbing Zhong and Shuo., Zebrafish tyrosine hydroxylase 2 Gene Encodes Tryptophan Hydroxylase. J. Biol. Chem. 2013, 288(31):22451-9. 

29. Lu J, Xin S, Meng H, Veldman M, Schoenfeld D, Che C, Yan R, Zhong H, Li S, Lin S.,A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay. PLoS One. 2013,26; 8(4):e53317.

28. Che C., Li S., Yu Z. X., Li F. F., Xin S. C., Zhou L. Y., Lin S., Yang, Z., One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy. ACS Combinatorial Science, 2013, 15 (4):202-207.


27.  Xin SC, Zhao YQ, Li S, Lin S, Zhong HB,Application of zebrafish models in drug screening.Yi Chuan. 2012, 34(9):1144-52.

26. Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin,Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors. Beilstein J. Org. Chem.2012,841-849.

25. Lu Chen, Xi Ren, Fang Liang, Song Li, Hanbing Zhong, Shuo Lin,Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis. Pigment Cell Melanoma Res.2012,25,446-453.

24. Zhang Y, Morimoto K, Danilova N, Zhang B, Lin S,Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS ONE.2012,7(1): e30188.  

23. Peng Huang,An Xiao,Mingguo Zhou,Zuoyan Zhu, Shuo Lin,Bo Zhang,Heritable gene targeting in zebrafish using customized TALENs.Nature Biotechnology.2011,29(8),699-700.

22. Guiqi Ren, Shengchang Xin, Song Li, Hanbing Zhong, Shuo Lin,Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish.PLoS ONE.2011, 6(6):e20630.

21. Hanbing Zhong, Danyang Wang, Nan Wang, Yesenia Rios, Haigen Huang, Song Li, Xinrong Wu,Shuo Lin,Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity.Cell Research.2011,41,1-8.

20. Ren X; Gomez GA; Zhang B; and Lin S,  Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood 2010, 115(26), 5338-46.

19. Chao Che,Song Li,Xianlong Jiang,Junmin Quan,Shuo Lin,and Zhen Yang,One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition.ORGANIC LETTERS.2010,12(20),4682-4685.

18. Hanbing Zhong,Shengchang Xin,Yanqiu Zhao,Jing Lu,Song Li,Jianxian Gong,Zhen Yang and Shuo Lin,Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Mol.BioSyst.2010, 6, 1463–1468.

17. Fei Qi,Jianbo Song,Hanshuo Yang,Wei Gao,Ning-ai Liu,Bo Zhang,and Shuo Lin,Mmp23b Promotes Liver Development and Hepatocyte Proliferation Through the Tumor Necrosis Factor Pathway in Zebrafish.HEPATOLOGY.2010,52(6),2158-2166.

16. Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman,Song Li, Jin Jiang,Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules,THE JOURNAL OF BIOLOGICAL CHEMISTRY.2009,284(31),20876–20884.

15. Jing Xiang, Hongbo Yang, Chao Che, Haixia Zou1, Hanshuo Yang, Yuquan Wei, Junmin Quan,Hui Zhang, Zhen Yang, Shuo Lin,Identifying Tumor Cell Growth Inhibitors by Combinatorial Chemistry and Zebrafish Assays,PLoS ONE.2009,4(2),e4361.

14. Hanbing Zhong,Haixia Zou,Mikhail V. Semenov,Deborah Moshinsky,Xi He,Haigen Huang,Song Li,Junmin Quan,Zhen Yanga and Shuo Lin,Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling,Mol. BioSyst.,2009,5, 13561360.

13. Sumanas S; Gomez G; Zhao Y; Park C; Choi K; and Lin S, Interplay between Etsrp/ER71, scl and alk8 signaling controls endothelial and myeloid cell formation. Blood. 2008, 111(9), 4500-10.

12. Danilova N; Sakamoto KM; and Lin S, Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. 2008, 112(13), 5228-37.

11. Sumanas S; and Lin, S.,  Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol 2006, 4(1), e10.

10. Wu, X.; Zhong, H.; Song, J.; Damoiseaux, R.; Yang, Z.; Lin, S., Mycophenolic acid is a potent inhibitor of angiogenesis. Arteriosclerosis Thrombosis and Vascular Biology 2006, 26, (10), 2414-2416.

9. Sumanas S, Jorniak T, Lin S. "Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants" Blood. 2005; 106,534-541.

8. Lee, KY.; Huang, H.; Ju, BS.; Yang Z.; and Lin, S., Cloned zebrafish by nuclear transfer from long-term cultured cells. Nature Biotechnology. 2002, 20, 795-799

7. Long, Q.; Huang, HG.; Shafizadeh, E.; Liu, N. and Lin, S., Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nature Cell Biology 2000, 2(8), 549-552.       

6. Jessen, JR.; Willett, CE. and Lin, S., Artificial chromosome transgenesis reveals long-distance negative regulation ofrag1 in zebrafish. Nature Genetics  1999, 23(1), 15-16.

5. Wang, H.; Long, QM.; Marty, S.; Sassa, S. and Lin, S., A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics 1998, 20, 239-243 (with News & Views).

4. Jessen JR, Meng A, McFarlane RJ, Paw BH, Zon LI, Smith GR, Lin S. "Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis" Proc Natl Acad Sci U S A. 1998; 95, 5121-5126.

3. Meng A, Tang H, Ong BA, Farrell MJ, Lin S. "Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2" Proc Natl Acad Sci U S A. 1997; 94, 6267-6272.

2. Long, QM.; Meng, AM.; Wang, H.; Jessen, JH.; Farrell, MJ. and Lin, S., GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 1997, 124, 4105-4111. 

1. Lin, S.; Gaiano, N.; Culp, P.; Burns, J.; Friedmann, T.; Yee, J-K; and N. Hopkins., Integration and germ line transmission of a pseudotyped retroviral vector in zebrafish. Science 1994, 265, 666-668.