We are a group of scientists in the School of chemical biology & biochemistry at PKU. We use zebrafish to investigate the molecular mechanisms by which diverse and specialized cell types are developed during vertebrate embryogenesis. Our main interests include studying hematopoietic and vascular development, and pancreas organogenesis. We also use zebrafish to model human diseases and facilitate the identification of therapeutic agents. Chemical biology coupled with zebrafish genetics has been used in our laboratory to identify and develop small molecule candidates with the potential to treat cancers. To better advance zebrafish as a model organism for the research community, we are undertaking genome-wide mutagenesis with retroviral insertions and large-scale transgenic reporter gene expression for tissue specific genes by using GFP/RFP enhancer traps and BAC transgenesis. To learn more about our research program, please click the related links or go to the Research page.