I. Work done in PKUSZ
(a) Publication on Natural Product Synthesis
19. Lizhi Zhu, Wenjing Ma, Mengxun Zhang, Magnolia Muk-Lan Lee, Wing-Yan Wong, Brandon Dow Chan, Qianqian Yang, Wing-Tak Wong, William Chi-Shing Tai and Chi-Sing Lee. Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds. Nat. Chem, 2018, 9, 1283-1292
18. Qianqian Yang, Wenjing Ma, Gaopeng Wang, Wenli Bao, Xiaoshu Dong, Xuefeng Liang, Lizhi Zhu,* and Chi-Sing Lee*. Tunable Cyclization Strategy for the Synthesis of Zizaene-, alloCedrane-, seco-Kaurane-, and seco-Atesane-Type Skeletons. Org. Lett, 2017, 19, 5324-5327
17. Guangyan Du, Gaopeng Wang, Wenjing Ma, Qianqian Yang, Wenli Bao, Xuefeng Liang, Lizhi Zhu, Chi-Sing Lee*. Syntheses of Diverse Natural Products via Dual-Mode Lewis Acid Induced Cascade Cyclization Reactions. Synlett 2017, 28, A–M
16. Xuefeng Liang, Liyan Zhou, Long Min, Weijian Ye, Wenli Bao, Wenjing Ma, Qianqian Yang, Fangfang Qiao, Xinhao Zhang* , and Chi-Sing Lee*. Diastereoselective Total Synthesis of (±)-Basiliolide B and (±)-epi-8-Basiliolide B. J. Org. Chem. 2017, 2, 3463–3481.
15. Guangyan Du, Wenli Bao, Junrong Huang, Shuangping Huang, Hong Yue, Wei Yang, Lizhi Zhu, Zhenhao Liang, and Chi-Sing Lee*. Enantioselective Synthesis of the ABC-Tricyclic Core of Phomactin A by a γ-Hydroxylation Strategy. Org. Lett. 2015, 17, 2062-2065.
14. Wei Yang, Jingming Cao, Mengxun Zhang, Rongfeng Lan, Lizhi Zhu, Guangyan Du, Shuzhong He*, and Chi-Sing Lee*. Systemic Study on the Biogenic Pathways of Yezo' otogirins: Total Synthesis and Antitumor Activities of (±)-Yezo' otogirin C and Its Structural Analogues. J. Org. Chem. 2015, 80, 836-846.
13. Long Min, Yang Zhang, Xuefeng Liang, Junrong Huang, Wenli Bao and Chi-Sing Lee*. A Biomimetic Synthesis of (±)-Basiliolide B. Angew. Chem. Int. Ed. 2014, 53, 11294-11297.
12. Shuzhong He, Wei Yang, Lizhi Zhu, Guangyan Du, and Chi-Sing Lee*. Bioinspired Total Synthesis of (±)-Yezo'otogirin C. Org. Lett, 2014, 16, 496-499.
11. Lizhi Zhu, Guangyan Du, Wei Yang, Long Min,Xiaozu Liu, Shuangping Huang, Yejian Han and Chi-Sing Lee*. Applications of Dual-Mode Lewis Acids Induced Cascade Cyclization Reactions in Natural Product Synthesis. Chin. J. Org. Chem. 2013, 33, 2031-2045
10. Lizhi Zhu, Congshan Zhou, Wei Yang, Shuzhong He, Gui-Juan Cheng, Xinhao Zhang*, and Chi-Sing Lee*. Formal Syntheses of (±)-Platensimycin and (+-)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach. J. Org. Chem. 2013, 78, 7912-7929.
9. Lizhi Zhu, Yejian Han, Guangyan Du and Chi-Sing Lee*. A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of Platensimycin. Org. Lett. 2013, 15, 524-527.
8. Xiaozu Liu and Chi-Sing Lee*. Total Synthesis of (-)-Teucvidin Org. Lett. 2012, 14. 2886-2889.
7. Shuangping Huang, Guangyan Du and Chi-Sing Lee*. Construction of the Tricyclic Furanochroman Skeleton of Phomactin A via the Prins/Conia-Ene Cascade Cyclization Approach J. Org. Chem. 2011, 76, 6534-6541.
6. Wanqing Wu, Long Min, Lizhi Zhu and Chi-Sing Lee*. A New Class of Enantioselective Catalytic 2-Pyrone Diels-Alder Cycloadditions. Adv. Synth. Catal. 2011, 353, 1135-1145.
5. Yejian Han, Lizhi Zhu, Yuan Gao, and Chi-Sing Lee*. A Highly Convergent Cascade Cyclization to cis-Hydrindanes with All-Carbon Quaternary Centers and Its Application in the Synthesis of the Aglycon of Dendronobiloside A. Org. Lett. 2011, 13, 588-591.
4. Wanqing Wu, Shuzhong He, Xiongfei Zhou and Chi-Sing Lee*. Diels-Alder Cycloadditions of 5-Hydroxy-2-pyrones: 2H-Pyran-2,5-diones and 5-(tert-Butyldimethylsilyloxy)-2-pyrones as Synthons. Eur. J. Org. Chem. 2010, 1124-1133.
3. Wei Li, Xiaozu Liu, Xiongfei Zhou and Chi-Sing Lee*. Amine-Induced Michael/Conia-Ene Cascade Reaction: Application to a Formal Synthesis of Clavukerin A Org. Lett. 2010, 12, 548-551.
2. Xiongfei Zhou, Wanqing Wu, Xiaozu Liu and Chi-Sing Lee*. Base-Catalyzed Diels-Alder Reactions of 2H-Pyran-2,5-diones: A Mild Approach to Basiliolide B. Org. Lett. 2008, 10, 5525-5528.
1. Weiguo Peng and Chi-Sing Lee*. InCl3-Mediated Cascade Reactions for the Construction of Highly Functionalized 1-Oxadecalins. Synlett. 2008, 142-146.
(b) Publication on Bio-Imaging
8. Weijian Ye, Junrong Huang, Zhenhao Lianga, Wenlu Zheng, Jing-Xiang Zhang, Chi-Sing Lee*. Responsive europium emission for paralytic shellfish saxitoxin detection in water. J. Lumin., 2018, 188, 28-33.
7. Zhenhao Liang, Tik-Hung Tsoi, Chi-Fai Chan, Lixiong Dai, Yudan Wu, Guangyan Du, Lizhi Zhu, Chi-Sing Lee,* Wing-Tak Wong,* Ga-Lai Law* and Ka-Leung Wong*. A smart “off–on” gate for the in situ detection of hydrogen sulphide with Cu(II)-assisted europium emission. Chem. Sci., 2016, 7, 2151.
6. Zhenhao Liang, Chi-Fai Chan, Yurong Liu, Wing-Tak Wong*, Chi-Sing Lee*, Ga-Lai Law* and Ka-Leung Wong*. The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications. RSC Adv. 2015, 5, 13347-13356.
5. Chi-TungYeung, Ho-LunYeung, Wesley Ting Kwok Chan, Siu-Cheong Yan, Eric C. Y. Tam, Ka-Leung Wong, Chi-Sing Lee and Wing-Tak Wong, Stereolabile chiral biphenyl hybrids: crystallization induced dynamic atropselective resolution involving supramolecular interactions Cryst. Eng. Comm. 2013, 15, 836-840.
4. Shuzhong He, Hongguang Li, Yuk-Wang Yip, Chi-Tung Yeung, Yuen On Fung, Hoi-Kuan Kong, Ho-Lun Yeung, Ga-Lai Law, Ka-Leung Wong, Chi-Sing Lee, Michael Hon-Wah Lam, Margaret B. Murphy, Paul Kwan-Sing Lam and Wing-Tak Wong “Responsive Two-Photon Induced Europium Emission as Fluorescent Indicator for Paralytic Shellfish Saxitoxin” Org. Lett. 2011, 13, 5036-5039.
3. Wanqing Wu, Hoi-Kuan Kong, Hongguang Li, Yu-Man Ho, Yuan Gao, Jianhua Hao, Margaret B. Murphy, Michael Hon-Wah Lam, Ka-Leung Wong, and Chi-Sing Lee “Comparative Studies of Multi-Photon Induced Emission by Pyridine-Based Small Molecular Probes in Biological Media – for Their Specify to Bioactive Molecules and In-Vitro Imaging” Eur. J. Org. Chem. 2011, 5054-5060.
2. Yuen On Fung, Wanqing Wu, Chi-Tung Yeung, Hoi-Kuan Kong, Kenny Kam-Cheng Wong, Wai-Sum Lo, Ga-Lai Law, Ka-Leung Wong, Chi-Kong Lau, Chi-Sing Lee, and Wing-Tak Wong “In Vitro Imaging and Human Serum Albumin Responsive Dimeric Lanthanide DO3A Complex” Inorg. Chem. 2011, 50, 5517-5525.
1. Hoi-Kwan Kong, Frances L. Chadbourne, Ga-Lai Law, Hongguang Li, Hoi-Lam Tam, Steven L Cobb, Chi-Kong Lau, Chi-Sing Lee, Ka-Leung Wong “Two-Photon Induced Responsive f-f Emissive Detection for Cyclin A with a Europium-Chelating Peptide” Chem. Commun. 2011, 47, 8052-8054.
II. Work done in the USA and Hong Kong
(a) Publication
17. Bo Wang, T. Matthew Hansen, Lynn Weyer, Dimao Wu, Ting Wang, Mathias Christmann, Yingtao Lu, Lu Ying, Mary M. Engler, Russell D. Cink, Chi-Sing Lee, Feryan Ahmed and Craig J. Forsyth, Total Synthesis of Phorboxazole A via de Novo Oxazole Formation: Convergent Total Synthesis, J. Am. Chem. Soc. 2011, 133, 1506-1516.
16. Bo Wang, T. Matthew Hansen, Ting Wang, Dimao Wu, Lynn Weyer, Lu Ying, Mary M. Engler, Melissa Sanville, Christopher Leitheiser, Mathias Christmann, Yingtao Lu, Jiehao Chen, Nicholas Zunker, Russell D. Cink, Feryan Ahmed, Chi-Sing Lee, and Craig J. Forsyth, Total Synthesis of Phorboxazole A via de Novo Oxazole Formation: Strategy and Component Assembly, J. Am. Chem. Soc. 2011, 133, 1484-1505.
15. Kiu-Chor Sha, Chi-Sing Lee, Ka-Yee Chan, Shek-Man Yiu, Wing-Tak Wong and, Hoi-Lun Kwong Coordination properties of axially unfixed chiral dipyridin, e ligands towards metal and ammoniumions Polyhedron 2011, 32, 1149-1156.
14. Wing-Leung Wong, Chi-Sing Lee, Pang-Fei Teng, and Hoi-Lun Kwong. Zinc(II) Complex of Terpyridine-Crown Macrocycle: A New Motif in Fluorescence Sensing of Zwitterionic Amino Acids. Inorg. Chem. Commun. 2009, 12, 815-818.
13. Hoi-Lun Kwong, Ho-Lun Yeung, Chi-Tung Yeung, Wing-Sze Lee, Chi-Sing Lee, Wing-Leung Wong. Chiral pyridine-containing ligands in asymmetric catalysis Coord. Chem. Rev. 2007, 251, 2188-2222.
12. Jiehao Chen, Lu Yi, ng, T. Matthew Hansen, Mary M. Engler, Chi Sing Lee, James J. La Clairb and Craig J. Forsyth, Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies. Bioorg. Med. Chem. Lett. 2006, 16, 901-904.
11. Chi-Sing Lee, Pang-Fei Teng, Wing-Leung Wong, Hoi-Lun Kwong and Albert S. C. Chan, New C2-symmetric 2,2’-bipyridine crown macrocycles for enantioselective recognition of amino acid derivatives Tetrahedron 2005, 61, 7924-7930.
10. Pui-Lam Ng, Chi-Sing Lee, Hoi-Lun Kwong and Albert S. C. Chan, Zinc complex of bipyridine crown macrocycle: Luminescence sensing of anions in aqueous media via the cooperative action of metal-ligand and hydrophobic interactions Inorg. Chem. Commun. 2005, 8, 769-772.
9. Wing-Sze Lee, Hon-Kit Leung, Leung-Shi Cheng, Lai-Yuen Ng, Chi-Sing Lee, Ka-Hung Huang, Wing-Tak Wong and Hoi-Lun Kwong, Chiral 2-pyridyl alcoholate copper complexes: crystal structures of [bis(2-pyridyl alcoholate)copper(II)] and the use of [(2-pyridyl alcoholate)-copper(II)]+and [(2-pyridyl alcoholate) copper(I)] in asymmetric cyclopropanation of styrene and allylic oxidation of cyclohexene, Inorg. Chim. Acta 2004, 357, 4389-4395.
8. Wing-Leung Wong, Chi-Sing Lee, Hon-Kit Leung and Hoi-Lun Kwong, The first series of chiral 2,2',6',2"-terpyridine tri-N-oxide ligands for Lewis base-catalyzed asymmetric allylation of aldehydes, Org. Biomol. Chem. 2004, 2, 1967-1969.
7. Hoi-Lun Kwong, Di Liu, Ka-Yee Chan, Chi-Sing Lee, Ka-Hung Huang and Chi-Ming Che, Copper(I)-catalyzed asymmetric alkene aziridination mediated by PhI(OAc)2: a facile one-pot procedure , Tetrahedron Lett. 2004, 45, 3965-3968.
6. Wing-Leung Wong, Ka-Hung Huang, Pang-Fei Teng, Chi-Sing Lee and Hoi-Lun Kwong, A novel chiral terpyridine macrocycle as a fluorescent sensor for enantioselective recognition of amino acid derivatives , Chem. Commun. 2004, 384-385.
5. Fred L. Ciske, Michael R. Barbachyn, Michael J. Genin, Kevin C. Grega, Chi Sing Lee, Lester A. Dolak, Eric P. Seest, William Watt, Wade J. Adams, Janice M. Friis, Charles W. Ford and Gary E. Zurenko, The Effect of Remote Chirality on the Antibacterial Activity of Indolinyl, Tetrahydroquinolyl and Dihydrobenzoxazinyl Oxazolidinones , Bioorg. Med. Chem. Lett. 2003, 13, 4235-4239.
4. Dan Yang, Qiang Gao, Chi-Sing Lee and Kung-Kai Cheung, Novel Intramolecular Cyclo-propanation Reaction of Unsaturated b-Keto Esters, Org. Lett. 2002, 4, 3271-3274.
3. Chi Sing Lee, Debra A. Allwine, Michael R. Barbachyn, Lester A. Dolak, Michael J. Genin, Kevin C. Grega, Randy M. Jensen and Eric P. Seest, Carbon-Carbon-Linked Pyrazolylphenyl-oxazolidinones with Antibacterial Activity Against Multiple Drug Resistant Gram-Positive Pathogens and Fastidious Gram-Negative Bacteria, Bioorg. Med. Chem. 2001, 9, 3243-3253.
2. Craig J. Forsyth, Feryan Ahmed, Russell D. Cink and Chi Sing Lee, Total Synthesis of Phorboxazole A, J. Am. Chem. Soc. 1998, 120, 5597-5598.
1. Chi Sing Lee and Craig J. Forsyth, Synthesis of the Central C18-C30 Core of the Phorboxazole Natural Products , Tetrahedron Lett. 1996, 37, 6449-6452.
(b) Patent
U.S. Patent 6,797,721, 2004; WO 01/36394, 2001; Priority: US 99-165452 19991115, Fatih M. Uckun, K. Rama, Craig Forsyth, Chi Sing Lee, Feryan Ahmed and Russell Drew Cink, Phorboxazole derivatives for treating cancer.
(c) Edited Book Chapters and Reference Works
2. Lam, M. H.-W.; Law, G.-L.; Lee, C. S.; Wong, K.-L. “Organic Molecules for Optical Imaging”, In The Chemistry of Molecular Imaging, Eds: Long, N.; Wong, W.-T., John Wiley & Sons, Ltd., 2015, pp. 245-274.
1. Dan Yang and Chi-Sing Lee, (R)-2,10-Dichloro-5H-dinaphtho[2,1-g:1,2-i] [1,5] dioxacycloundecin-3,6,9(7H)-trione , In e-EROS Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 2003.
