Huang Group
School of Chemical Biology & Biotechnology

Leifeng wang’ s paper has been published on line in Angew. Chem. Int. Ed.! Congratulations!


Visible Light Mediated [4+2] Cycloaddition of Styrenes Synthesis of Tetralin Derivatives

Leifeng Wang, Fengjin Wu, Jiean Chen, David A. Nicewicz,* and Yong Huang*,  Angew. Chem. Int. Ed. 2017, 56, 6896-6900. DOI: 10.1002/ange.201702940

We report a formal [4+2] cycloaddition reaction of styrenes under visible-light catalysis. Two styrene molecules with different electronic or steric properties were found to react with each other in good yield and excellent chemo- and regioselectivity. This reaction provides direct access to polysubstituted tetralin scaffolds from readily available styrenes. Sophisticated tricyclic and tetracyclic tetralin analogues were prepared in high yield and up to 20/1 diasteroselectivity from cyclic substrates.