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Visible Light Mediated [4+2] Cycloaddition of Styrenes Synthesis of Tetralin Derivatives
Leifeng Wang, Fengjin Wu, Jiean Chen, David A. Nicewicz,* and Yong Huang*, Angew. Chem. Int. Ed. 2017, 56, 6896-6900. DOI: 10.1002/ange.201702940
We report a formal [4+2] cycloaddition reaction of styrenes under visible-light catalysis. Two styrene molecules with different electronic or steric properties were found to react with each other in good yield and excellent chemo- and regioselectivity. This reaction provides direct access to polysubstituted tetralin scaffolds from readily available styrenes. Sophisticated tricyclic and tetracyclic tetralin analogues were prepared in high yield and up to 20/1 diasteroselectivity from cyclic substrates.