Chao Che, Ph.D.
Associate Professor
Tel: 0755-26032530
E-mail: chec@pkusz.edu.cn

Education & Experience:
09/2010-present Adjunct Associate Professor, Peking University Shenzhen Graduate School
04/2009-present Director of Chemistry, Shenzhen Shengjie Biotech. Co. Ltd.
07/2007-04/2009 Associate Professor, Peking University Shenzhen Graduate School
07/2005-07/2007 Postdoctoral Fellow, Peking University Shenzhen Graduate School
07/2002-04/2005 Ph.D. Institute of Zoology, Chinese Academy of Sciences
09/1999-07/2002 M.S. Department of Applied Chemistry, China Agriculture University
09/1995-07/1999 B.S. Department of Applied Chemistry, China Agriculture University
Research Interest:
1. Diversity-oriented synthesis of small molecules through developing novel multi-component reaction for drug screening;
2. Target-oriented synthesis of biologically active natural and manmade products;
3. Synthesis and evaluation of novel kinase inhibitors (CDK2, PLK1) and signal pathway inhibitors (Hedgehog, Wnt).
Research Funds:
1. Diversity-oriented synthesis of drug-like small molecules by novel multi-component reaction strategies (Sole Investigator, 2012-2014), supported by NSFC (Grant 21102006).
2. MCR-based synthesis and zebrafish-based screening of CDK2 inhibitors (Sole Investigator, 2011-2013), supported by Natural Science Foundation of Guangdong Province (Grant S2011010000185)
Selected Publications:
1. Che C.,* Yang Bo, Jiang Xianlong, Shao Taofeng, Yu Zhixiong, Tao Chuanye, Li Song, and Lin Shuo , Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-Annulation, J. Org. Chem., 2014, 79, 436-440.
2. Lu J., Xin S. C., Meng H., Veldman, M., Schoenfeld D., Che C., Yan R. B., Zhong H. B., Li S., Lin S., A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay, Public Library of Science One (PLoS ONE), 2013, 8(4), e53317.
3. Che C.,* Li S., Yu Z. X., Li F. F., Xin S. C., Zhou L. Y., Lin S.,* Yang, Z.,* One-Pot Syntheses of Isoquinolin-3-ones and Benzo-1,4-diazepin-2,5-diones Utilizing Ugi-4CR Post-Transformation Strategy, ACS Combinatorial Science, 2013, 15 (4), 202-207.
4. Che C., Li S., Yang B., Xin S. C., Yu Z. X., Shao, T. F., Tao, C. Y., Lin S.,* Yang, Z.,* Synthesis and Characterization of Sant-75 Derivatives as Hedgehog Pathway Inhibitors, Beilstein Journal of Organic Chemistry, 2012, 8, 841-849.
5. Che C.,* Li S., Jiang X. L., Quan J. M., Lin S., Yang, Z.,* One-Pot Synthesis of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition, Organic Letters, 2010, 12, 4682-4685.
6. Che C., Liu L. Z., Gong J. X., Yang, Y. F., Wang, G. X., Quan, J. M., Yang Z., Construction of All Carbon Quarternary Center by AlR2Cl-Mediated Ring-Opening Reaction of Oxacycles, Organic Letters, 2010, 12 (3), 488-491.
7. Che C.,* Li W. Z., Lin S. Y., Chen J. W., Zheng J., Wu J., Zheng Q. X., Zhang G. Q., Yang Z.* and Jiang B. W.*; Magnetic Nanoparticle-Supported Hoveyda-Grubbs Catalysts for Ring-Closing Metathesis Reactions. Chemical Communications, 2009, 5990-5992.
8. Liu L. Z., Gao Y. X., Che C., Wu N., Wang David Z., Li C. C., Yang Z.; A Model Study for the Concise Construction of the Oxapentacyclic Core of Cortistatins through Intramolecular Diels-Alder and Oxidative Dearomatization -Cyclization Reactions. Chemical Communications, 2009, (6), 662-664.
9. Xiang J., Yang H. B., Che C., Zou H. X., Yang H. S., Wei Y. Q., Quan J. M., Zhang H., Yang Z. and Lin S.; Identifying Tumor Cell Growth Inhibitors by Combinatorial Chemistry and Zebrafish Assays. Public Library of Science One (PLoS ONE), 2009, 4(2), e4361.
10. Che C., Xiang J., Quan J.-M. and Yang Z.; A One-Pot Synthesis of Functionalized Quinoline-based Poly-Heterocycles by a Tandem Three-Component Reaction. J. Comb. Chem. 2007, 9, 982-989.
11. Che C. and Zhang Z.-N.; Concise Total Synthesis of (3Z, 6Z, 9S, 10R)-9, 10-Epoxy-1, 3, 6-Heneicosatriene, Sex Pheromone Component of Hyphantria cunea. Tetrahedron, 2005, 61, 2187-2193.