11. “An Artificial Enzyme for Asymmetric Nitrocyclopropanation of α,β-Unsaturated Aldehydes – Design and Evolution” Ming-Zhu Yu,# Ye Yuan,# Zhen-Jie Li,# Thittaya Kunthic, He-Xiang Wang, Chen Xu, and Zheng Xiang*. Angew. Chem. Int. Ed. 2024, 63, e202401635.
10. “Conformational Control in Diterpene Synthase TlnA: Elucidating the Mechanism of 5–8–6 Skeleton Formation through Ring Expansion” Fengli Li, Suitian Lai, Wenling Yuan, Zhe Chen, Zhenhua Guan, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Jaclyn M. Winter, Zheng Xiang, Junjun Liu,* Ying Ye,* and Yonghui Zhang*. Org. Lett. 2024, 26, 1734–1738.
9. “Harnessing the Catalytic Plasticity of the ent-Kaurene Synthase from Bradyrhizobium japonicum to Produce the ent-Rosane and ent-Pimarane Scaffolds” Fan Zhang,# Su-Jing Wang,# Wen Xiao,# Ming-Zhu Yu, Feng Sha, Ruibo Wu* and Zheng Xiang*. Catal. Sci. Technol. 2024, 14, 306–314.
8. “Chemoenzymatic Synthesis of Cylindrocyclophanes A and F and Merocyclophanes A and D” Kai-Yue Chen, Hua-Qi Wang, Ye Yuan, Shu-Bin Mou and Zheng Xiang*. Angew. Chem. Int. Ed. 2023, 62, e202307602.
7. “Chemoenzymatic synthesis of (+)-isoagatholactone, (+)-spongian-16-one, and 3-deoxychavalone A via biocatalytic polyene cyclization” Wen Xiao,# Su-Jing Wang,# Ming-Zhu Yu, Xue-Jie Zhang and Zheng Xiang*. Org. Biomol. Chem. 2023, 21, 5527–5531.
6. “Metabolic Engineering for Efficient Production of Z,Z-Farnesol in E. coli” Mengyang Lei, Zetian Qiu, Leilei Guan, Zheng Xiang* and Guang-Rong Zhao*. Microorganisms 2023, 11, 1583.
5. “Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase” Ming-Zhu Yu, Kai-Yue Chen, Yi-Bin Zhang, Chang-Xuan Zhang and Zheng Xiang*. Org. Biomol. Chem. 2023, 21, 2086–2090.
4. “Structural Basis for the Friedel-Crafts Alkylation in Cylindrocyclophane Biosynthesis” Hua-Qi Wang, Shu-Bin Mou, Wen Xiao, Huan Zhou, Xu-Dong Hou, Su-Jing Wang, Qian Wang, Jiali Gao*, Zhiyi Wei*, Lijun Liu*, and Zheng Xiang*. ACS Catal. 2022, 12, 2108–2117.
3. “Syntheses of the Carotane-type Terpenoids (+)-Schisanwilsonene A and (+)-Tormesol via a Two-Stage Approach” Shu-Bin Mou, Wen Xiao, Hua-Qi Wang, Kai-Yue Chen and Zheng Xiang*. Org. Lett. 2021, 23, 400–404.
2. “Activity-based Genetically Encoded Fluorescent and Luminescent Probes for Detecting Formaldehyde in Living Cells” Yuqing Zhang, Yimeng Du, Manjia Li, Dong Zhang, Zheng Xiang, and Tao Peng*. Angew. Chem. Int. Ed. 2020, 59, 16352–16356.
1. “Syntheses of Epoxyguaiane Sesquiterpenes (-)-Englerin A, (-)-Oxyphyllol, (+)-Orientalol E, and (+)-Orientalol F: A Synthetic Biology Approach” Shu-Bin Mou,# Wen Xiao,# Hua-Qi Wang, Su-Jing Wang, and Zheng Xiang*. Org. Lett. 2020, 22, 1976–1979.
Publications before joing PKUSZ:
19. “Genetically Encoding an Electrophilic Amino Acid for Protein Stapling and Covalent Binding to Native Receptors” Xiaohua Chen, Zheng Xiang, Ying S. Hu, Vanessa Lacey, Hu Cang and Lei Wang. ACS Chem. Biol. 2014, 9, 1956-1961. Recommended by Faculty of 1000: http://f1000.com/prime/718487039
18. “Proximity Enabled Protein Crosslinking via Genetically Encoding Haloalkane Unnatural Amino Acids” Zheng Xiang, Vanessa K. Lacey, Haiyan Ren, Jing Xu, David J. Burban, Patricia A. Jennings and Lei Wang. Angew. Chem. Int. Ed. 2014, 53, 2190-2193.
17. “Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR” Irene Coin, Vsevolod Katritch, Tingting Sun, Zheng Xiang, Fai Yiu Siu, Michael Beyermann, Raymond C. Stevens and Lei Wang. Cell 2013, 155, 1258-1269. Recommended by Faculty of 1000: http://f1000.com/prime/718194625. Highlighted by Nat. Methods 2014, 11, 10
16. “In Vivo Expression of a Light-Activatable Potassium Channel Using Unnatural Amino Acids” Ji-Yong Kang, Daichi Kawaguchi, Irene Coin, Zheng Xiang, Dennis D. M. O’Leary, Paul A. Slesinger and Lei Wang. Neuron 2013, 80, 358-370. Highlighted by ScienceDaily October 17, 2013 and KPBSTM Radio News October 17, 2013.
15. “Add an unnatural covalent bond to proteins through proximity-enhanced bioreactivity” Zheng Xiang, Haiyan Ren, Ying S. Hu, Irene Coin, Jing Wei, Hu Cang and Lei Wang. Nat. Methods. 2013, 10, 885-8. Highlighted by Chemical & Engineering News, 91(32), August 12, 2013 and ScienceDaily August 5, 2013. Recommended by Faculty of 1000: http://f1000.com/prime/718112868
14. “Expanding the Genetic Code of Caenorhabditis elegans Using Bacterial aminoacyl-tRNA Synthetase/tRNA Pairs” Angela R. Parrish, Xingyu She, Zheng Xiang, Irene Coin, Zhouxin Shen, Steven P. Briggs, Andrew Dillin, Lei Wang. ACS Chem. Biol. 2012, 7, 1292-302. Recommended by Faculty of 1000: http://f1000.com/prime/716797801
13. “RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites” David B. F. Johnson, Jianfeng Xu, Zhouxin Shen, Jeffrey K. Takimoto, Matthew D. Schultz, Robert J. Schmitz, Zheng Xiang, Joseph R. Ecker, Steven P. Briggs and Lei Wang. Nat. Chem. Biol. 2011, 7, 779-86. Highlighted by ScienceDaily September 22, 2011 and KPBSTM Radio News September 23, 2013. Recommended by Faculty of 1000: http://f1000.com/prime/13371154
12. “Enantiospecific Synthesis of Genetically Encodable Fluorescent Unnatural Amino Acid L-3-(6-Acetylnaphthalen-2-y- lamino)-2-aminopropanoic Acid” Zheng Xiang and Lei Wang. J. Org. Chem. 2011, 76, 6367-71.
11. “Genetically Encoding Unnatural Amino Acids in Neural Stem Cells and Optically Reporting Voltage-Sensitive Domain Changes in Differentiated Neurons” Bin Shen, Zheng Xiang, Barbara Miller, Gordon Louie, Wenyuan Wang, Joseph P. Noel, Fred H. Gage, Lei Wang. Stem Cells. 2011, 29, 1231-40. Highlighted by ScienceDaily July 11, 2011.
10. “Esterification of an Unnatural Amino Acid Stucturally Deviating from Canonical Amino Acids Promotes Its Uptake and Incorporation into Proteins in Mammalian Cells” Jeffrey K. Takimoto, Zheng Xiang, Ji-Yong Kang and Lei Wang. ChemBioChem 2010, 11, 2268-72.
9. “Improving Orthogonal tRNA-synthetase Recognition for Efficient Unnatural Amino Acid Incorporation and Applicat- ion in Mammalian Cells” Jeffrey K. Takimoto, Katrina L. Adams, Zheng Xiang and Lei Wang. Mol Biosyst 2009, 5, 931-4.
8. “Enantioselective Total Syntheses of (+)-Gallocatechin, (-)-Epigallocatechin, and (-)-8-C-Ascorbylepigallocatechin” Guang Lin, Le Chang, Yongxiang Liu, Zheng Xiang, Jiahua Chen and Zhen Yang. Chem. Asian J. 2013, 8, 700-4.
7. “Rapid Construction of [5-6-7] Tricyclic Ring Skeleton of Calyciphylline Alkaloid Daphnilongeranin B” Chen Xu, Zheng Liu, Huifei Wang, Bo Zhang, Zheng Xiang, Xiaojiang Hao and David Zhigang Wang. Org. Lett. 2011, 13, 1812-5.
6. “Formal Total Synthesis of N-Methylmaysenine” Lin Wang, Jianxian Gong, Lujiang Deng, Zheng Xiang, Zhixing Chen, Yuefan Wang, Jiahua Chen and Zhen Yang. Org. Lett. 2009, 11, 1809-12.
5. “Synthesis of Catechins via Thiourea-AuCl3-catalyzed Cycloalkylation of Aryl Epoxides” Yongxiang Liu, Xiben Li, Guang Lin, Zheng Xiang, Jing Xiang, Mingzhe Zhao, Jiahua Chen and Zhen Yang. J. Org. Chem. 2008, 73, 4625-9.
4. “Synthesis of Functionalized Quinolines via Ugi and the Pd-catalyzed Arylation Reactions” Zhibo Ma, Zheng Xiang, Tuoping Luo, Kui Lu, Zhibin Xu, Jiahua Chen and Zhen Yang. J. Comb. Chem. 2006, 8, 696-704.
3. “Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene-Ene RCM” Kui Lu, Mengwei Huang, Zheng Xiang, Yongxiang Liu, Jiahua Chen and Zhen Yang. Org. Lett. 2006, 8, 1193-6.
2. “A Conside and Diversity-Oriented Strategy for the Synthesis of Benzofurans and Indoles via Ugi and Diels-Alder Reactions” Kui Lu, Tuoping Luo, Zheng Xiang, Zejin You, Reza Fathi, Jiahua Chen and Zhen Yang. J. Comb. Chem. 2005, 7, 958-67.
1. “Concise Synthesis of Isoquinoline via the Ugi and Heck Reactions” Zheng Xiang, Tuoping Luo, Kui Lu, Jiayue Cui, Xiaomeng Shi, Reza Fathi, Jiahua Chen and Zhen Yang. Org. Lett. 2004, 6, 3155-8.