118.Asymmetric total synthesis of (−)-perforanoid A
Chao, Lv ; Qian, Tu ; Jianxian, Gong*; Xiaojiang, Hao*; Zhen, Yang*
Asymmetric total synthesis of (−)-perforanoid A, a novel limonoid isolated from the leaves ofHarrisonia perforata, has been achieved. The key features of our total synthesis include the Rh-catalyzed intramolecular Pauson–Khand reaction of an allene and an alkene, the Pd-catalyzed lactonization of an allylic alcohol with a vinyl ether, and the enantioselective alkenylation of 3-furaldehyde.