19.Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene-Ene RCM

K. Lu, M. W. Huang, Z. Xiang, Y. Liu, J. H. Chen*, Z. Yang*

Org. Lett., 20068, 1193.

A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene−ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.