32.Total Synthesis of Crisamicin A
Z. T. Li, Y. X. Gao, Y. F. Tang, M. J. Dai, G. X. Wang, Z. G. Wang* and Z. Yang*
Stereoselective total synthesis of natural product crisamicin A (1) was accomplished for the first time via the Pd/TMTU-catalyzed alkoxycarbonylative annulation to generate a uniquecis-pyran-fused lactone, an intermolecular Diels−Alder reaction to construct the pyranonaphthoquinone unit, and a novel Pd−thiourea pincer complex-catalyzed homocoupling of functionalized naphthoquinones.
