33.Synthesis of Catechins via Thiourea/AuCl3-Catalyzed Cycloalkylation of Aryl Epoxides
Y. X. Liu, X. Li, G. Li, Z. Xiang, J. Xiang, M. Z. Zhao, J. Chen*, Z. Yang*
A diversity-oriented approach for the synthesis of structurally diverse catechins was achieved in good yields via thiourea/AuCl3/AgOTf-catalyzed annulations of aryl epoxides under mild conditions. This new protocol provides a highly efficient entry to a library of catechins-derived natural products, notably anti-HIV agent 8-C-ascorbyl-(−)-epigallocatechin.
