45. Identification of a Highly Efficient Alkylated Pincer Thioimido-Palladium(II) Complex as the Active Catalyst in Negishi Coupling

J. Liu, H. Wang, H. Zhang, X. Wu, H. Zhang, Y. Deng, Z. Yang*, A. Lei*

Chem. Eur. J. 2009, 15, 4437.

Pd^IIate complex: A novel alkylated pincer thioimido–Pd complex generated from a catalyst precursor and basic organometallic reagents (RM) was observed by in situ IR,¹H NMR, and ¹³C NMR spectroscopies for the first time and proved to be the active catalyst in stoichiometric and catalytic reactions of aryl iodides with RM (see scheme). The catalyst, as an electron-rich Pd^II species, promoted the Negishi coupling of aryl iodides and alkylzinc reagents with high efficiency, even at low temperatures (0 or −20 °C).