Zhai Group
School of Chemical Biology & Biotechnology

Wang’s work has been published in Chemical Communications! Congratulations!


Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

Sasa WangXinzheng Chen, Qiaoqiao Ao, Huifei Wang* and Hongbin Zhai*

Chem. Commun., 2016, Advance Article

DOI: 10.1039/C6CC03835B

A new decarboxylative Csp3–Csp3 coupling approach for the benzylation of ketone enolates has been developed. A variety of raspberry ketone derivatives were conveniently synthesized in good to excellent yields under mild conditions. A crossover reaction shed light on the mechanism of this tandem reaction.