欧阳昆富-简历

欧阳昆富，博士

邮箱：Ouyang_kunfu@pku.edu.cn 或 Ouyangkunfu@gmail.com

教育经历：
2005.07 北京大学生命科学学院生物物理学专业、理学博士
1999.07 北京大学生命科学学院生理与生物物理学专业、理学学士

工作经历:
2013.03-至今北京大学深圳研究生院药物研究中心、特聘研究员、博士生导师、副教授
2011.07-2013.03 加州大学圣地亚哥分校医学院助理研究员
2005.09-2011.07 加州大学圣地亚哥分校医学院博士后

研究方向与技术专长：
心血管重构型疾病如心衰与血管内膜增生等的分子机制，擅长于小鼠心血管疾病模型的构建与生理组学分析

个人荣誉：
2019年深圳市“地方级领军人才”
2014年深圳市“孔雀计划”海外高层次人才B类
2012年北京大学“百人计划”入选者
2011年加州大学圣地亚哥分校基础研究Schulman Award
2007 年北京大学优秀博士论文二等奖
2007年美国心脏学会Clifford & Evelyn Cherry Fellowship Award
2007年美国心脏学会博士后奖学金
2001年北京大学论文创新一等奖

部分已发表论文:
35. Chen Z, Duan Y, Wang H, Tang H, Wang S, Wang X, Liu J, Fang X, Ouyang K. (2021) Atypical protein kinase C is essential for embryonic vascular development in mice. Genesis. Accepted.
34. Liu C, Spinozzi S, Feng W, Chen Z, Zhang L, Zhu S, Wu T, Fang X, Ouyang K, Evans SM, Chen J. (2020) Homozygous G650del nexilin variant causes cardiomyopathy in mice. JCI Insight. 5(16):138780. doi: 10.1172/jci.insight.138780.
33. Spinozzi S, Liu C, Chen Z, Feng W, Zhang L, Ouyang K, Evans SM, Chen J. (2020) Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes. Circ Heart Fail. doi: 10.1161/CIRCHEARTFAILURE.120.006935.
32. Quan C, Du Q, Li M, Wang R, Ouyang Q, Su S, Zhu S, Chen Q, Sheng S, Chen L, Wang H, Campbell DG, MacKintosh C, Yang Z, Ouyang K, Wang HY, Chen S. (2020) A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. Nat Commun. 11(1):2186. doi: 10.1038/s41467-020-16116-9.
31. Duan Y, Tang H, Mitchell-silbaugh K, Fang X, Han Z, Ouyang K. (2020) Heat shock protein 60 in cardiovascular physiology and diseases. Front Mol Biosci. 7: 73. Doi: 10.3389/fmolb.2020.00073. (Review)
30. Yang F, Huang L, Tso A, Wang H, Cui L, Lin L, Wang H, Ren M, Fang X, Liu J, Han Z, Chen J, Ouyang K. (2020) Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability. Plos Genetics. 16(4): e1008739. doi: 10.1371/journal.pgen.1008739.
29. Duan Y, Wang H, Mitchell-silbaugh K, Cai S, Fan F, Li Y, Tang H, Wang G, Fang X, Liu J, Jia N, Jing R, Ouyang K. (2019) Heat shock protein 60 regulates yolk sac erythropoiesis in mice. Cell Death Dis. 10: 766. doi: 10.1038/s41419-019-2014-2.
28. Pinto-Duarte A, Roberts AJ, Ouyang K, Sejnowski TJ. (2019) Impairments in remote memory caused by the lack of Type 2 IP3 receptors. Glia. 67(10):1976-1989. doi: 10.1002/glia.23679.
27. Fan F, Duan Y, Yang F, Trexler C, Wang H, Huang L, Li Y, Tang H, Wang G, Fang X, Liu J, Jia N, Chen J, Ouyang K. (2020) Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. Cell Death Diff. 27(2):587-600. doi: 10.1038/s41418-019-0374-x.
26. Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J. (2019) Nexilin is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. doi: 10.1161/CIRCULATIONAHA.119.039751. [Epub ahead of print]
25. Lin Q, Zhao L, Jing R, Trexler C, Wang H, Li Y, Tang H, Huang F, Zhang F, Fang X, Liu J, Jia N, Chen J, Ouyang K. (2019) IP3Rs in endothelial cells play an essential role in vasodilation and blood pressure regulation. J Am Heart Assoc. 8(4): e011704. doi: 10.1161/JAHA.118.011704.
24. Quan C, Li M, Du Q, Chen Q, Wang H, Campbell DG, Fang L, Xue B, MacKintosh C, Gao X, Ouyang K, Wang HY, Chen S. (2019) SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain. Circ Res. 124(5): 712-726. doi: 10.1161/CIRCRESAHA.118.313916.
23. Fang X, Bogomolovas J, Zhou P, Mu Y, Ma X, Chen Z, Zhang L, Zhu M, Veevers J, Ouyang K, Chen J. (2019) P209L Mutation in BAG3 Does Not Cause Cardiomyopathy in Mice. Am J Physiol Heart Circ Physiol. 316(2):H392-H399. doi: 10.1152/ajpheart.00714.2018.
22. Wang H, Jing R, Trexler C, Li Y, Tang H, Pan Z, Zhu S, Zhao B, Fang X, Liu J, Chen J, Ouyang K. (2019) Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality. J Gastroenterol. 54(5):407-418. doi: 10.1007/s00535-018-1522-7.
21. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. (2017). Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 127(8): 3189-3200.
20. Tang H, Wang H, Lin Q, Fan F, Zhang F, Peng X, Fang X, Liu J, Ouyang K. (2017) Loss of IP3 Receptor–Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function. J Immunol. 199 (2): 570-580; DOI: https://doi.org/10.4049/jimmunol.1700109
19. Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Gao S, Ouyang K, Yang H-T. (2017) IP3R-Mediated Ca2+ Signals Govern Hematopoietic and Cardiac Divergence of Flk1+ Cells via the Calcineurin-NFATc3-Etv2 Pathway. J Mol Cell Biol. 9(4):274-288; doi: 10.1093/jmcb/mjx014. [Epub ahead of print]
18. Lin Q, Zhao G, Fang X, Peng X, Tang H, Wang H, Jing R, Liu J, Lederer WJ, Chen J, Ouyang K. (2016) IP3 receptors regulate vascular smooth muscle contractility and hypertension. JCI Insight. 1(17):e89402. doi: 10.1172/jci.insight. 89402.
17. Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT. (2016) Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 12(3):465-78
16. Ouyang K, Gomez-Amaro R, Stachura D, Tang H, Peng X, Fang X, Traver D, Evans SM, Chen J. (2014) Loss of IP3R-mediated Ca2+ signaling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat. Commun. doi: 10.1038/ncomm5814.
15. Chapman MA, Zhang J, Banerjee I, Guo LT, Zhang Z, Shelton GD, Ouyang K, Lieber RL, Chen J. (2014) Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle. Hum Mol Genet. 23(22): 5879-92.
14. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. (2013) PLC, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart. Sci Signal. 6 (306): 1-11
13. Zhang R, Han P, Yang H, Ouyang K, Lee K, Lin Y, Ocorr K, Kang G, Chen J, Stainier D, Yelon D, Chi NC. (2013) In Vivo Cardiac Reprogramming Contributes to Zebrafish Heart Regeneration. Nature 498: 497–501
12. Cooley N, Ouyang K*, McMullen JR, Sadoshima J, Kiriasis H, Wu W, Mu Y, Du X, Chen J, Woodcock EA. (2013) No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy. Circulation: Heart Failure 6: 318-325. (*, Co-first author).
11. Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, Wang G, Wu Q, Wei C, Bi Y, Jiang L, Cai Z, Sun H, Zhang K, Zhang Y, Chen J, Fu X. (2013) Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits. Cell 152: 82–96.
10. Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M. (2012) InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485: 128-132.
9. Sheikh F, Ouyang K*, Campbell S, Lyon R, Chuang J, Fitzsimons D, Tangney J, Hidalgo C, Chung C, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens J, Peterson K, Granzier H, Moss R, McCulloch AD and Chen J. (2012) Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J. Clin. Invest. 122(4): 1209-1221. (*, Co-first author).
8. Jem A. Efe, Simon Hilcove, Janghwan Kim, Hongyan Zhou, Kunfu Ouyang, Gang Wang, Ju Chen, Sheng Ding (2011) Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 13: 215-222.
7. Guiling Zhao, Zachary Neeb, M. Dennis Leo, Judith Pachuau, Adebowale Adebiyi, Kunfu Ouyang, Ju Chen, Jonathan H. Jaggar (2010) Type 1 IP3 receptors activate BKCa channels via local molecular coupling in cerebral artery smooth muscle cells. J. Gen. Physiol. 136:283-291.
6. Stephan Lange, Kunfu Ouyang*, Gretchen Meyer, Li Cui, Hongqiang Cheng, Richard L. Lieber, Ju Chen (2009) Obscurin regulates longitudinal SR architecture. J. Cell. Sci. 122: 2640-2650 (*, Co-first Author).
5. Chaoliang Wei, Xianhua Wang, Min Chen, Kunfu Ouyang, Long-Sheng Song, Heping Cheng (2009) Calcium flickers steer cell migration. Nature 457: 901-905.
4. Wang Wang, Huaqiang Fang, Linda Groom, Aiwu Cheng, Wanrui Zhang, Jie Liu, Xianhua Wang, Kaitao Li, Peidong Han, Ming Zheng, Jinhu Yin, Weidong Wang, Mark P. Mattson, Joseph P. Y. Kao, Edward G. Lakatta, Shey-Shing Sheu, Kunfu Ouyang, Ju Chen, Robert T. Dirksen, Heping Cheng (2008) Superoxide Flashes in Single Mitochondria. Cell 134: 279-290.
3. Chen-Leng Cai, Jody C. Martin, Yunfu Sun, Li Cui, Liangchun Wang, Kunfu Ouyang, Lei Yang, Lei Bu, Xingqun Liang, Xiaoxue Zhang, Williang B. Stallcup, Christopher P. Denton, Andrew McCulloch, Ju Chen & Sylvia M. Evans (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature 454: 104-108.
2. Kunfu Ouyang, Hui Zheng, Xiaomei Qin, Chen Zhang, Dongmei Yang, Xian Wang, Caihong Wu, Zhuan Zhou & Heping Cheng (2005) Ca2+ sparks and secretion in dorsal root ganglion neurons. Proc. Natl. Acad. Sci. USA 102: 12259-12264 (*, Co-first Author).
1. Kunfu Ouyang, Caihong Wu & Heping Cheng (2005) Ca2+-induced Ca2+ release in sensory neurons: low-gain amplification confers intrinsic stability. J. Biol. Chem. 280: 15898-15902.