Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

• Alaji Bah,
• Robert M. Vernon,
• Zeba Siddiqui,
• Mickaël Krzeminski,
• Ranjith Muhandiram
• + et al.

The structural polymorphism of intrinsically disordered protein 4E-BP2 allows it to regulate translation initiation through post-translational modification-mediated folding, exemplifying a new and potentially general mechanism of biological regulation mediated by intrinsically disordered proteins.