The Quan Lab
School of Chemical Biology & Biotechnology

Phosphorylation regulates folding of an intrinsically disordered protein



  • Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

    • Alaji Bah,
    • Robert M. Vernon,
    • Zeba Siddiqui,
    • Mickaël Krzeminski,
    • Ranjith Muhandiram
    • + et al.

    The structural polymorphism of intrinsically disordered protein 4E-BP2 allows it to regulate translation initiation through post-translational modification-mediated folding, exemplifying a new and potentially general mechanism of biological regulation mediated by intrinsically disordered proteins.