The Quan Lab
School of Chemical Biology & Biotechnology

Peer reviewed articles

34. Wang X, Wang Y, Cao A, Luo Q, Chen D, Zhao W, Xu J, Li Q, Bu X, Quan J. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nat Commun. 2023 Oct 2;14(1):6132. 

33. Zhang Z, Fu N, Li Q, Quan J. Development of a novel anti-inflammatory recombinant uricase with extended half-life for gout therapy. Biochem Biophys Res Commun. 2023 Jul 23;666:115-121.

32. Xu B, Wang X, Xu Z, Li Q, Quan J. N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson's disease. Neurosci Lett. 2022 Jun 20;784:136751.

31. Chen Y, Cao A, Li Q, Quan J. Identification of DNA aptamers that specifically targets EBV+ nasopharyngeal carcinoma via binding with EphA2/CD98hc complex. Biochem Biophys Res Commun. 2022 Jun 11;608:135-141.

30. Fu J, Liu S, Hu M, Liao X, Wang X, Xu Z, Li Q, Quan J. Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production. ChemMedChem. 2022 Jan 4:e202100674.

29. Liu SY, Zhang QZ, Hu MQ, Li FX, Fu JM, Zhu ZD, Li QK, Yang Z, Quan JM. Targeting Extracellular Cyclophilin A via an Albumin-Binding Cyclosporine A Analogue. ChemMedChem. 2021 Dec 14;16(24):3649-3652. 

28.Jianwen Pei, Yibo Zhang, Qinhong Luo, Wenlv Zheng, Wanxuan Li, Xin Zeng, Qinkai Li, Junmin Quan*. STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity[J]. Cancer letters, 2019, 450: 110-122.

27.Chen Shen, Jianwen Pei, Xiaomin Guo, Lu Zhou, Qinkai Li & Junmin Quan*. Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8[J]. Scientific reports, 2018, 8(1): 16723.

26. Yibo Zhang, Zhen Sun, Jianwen Pei, Qinhong Luo, Xin Zeng, Qinkai Li, Zhen Yang, Junmin Quan*. “Identification of alpha-Mangostin as A Potent Agonist of Human STING”. ChemMedChem, 2018.

25. Chen Shen, Hong Yue, Jianwen Pei, Xiaomin Guo, Tao Wang*, Junmin Quan* “Crystal structure of the death effector domains of caspase-8” BBRC, 2015, 463, 297–302.

24. Hong Yue, Feng Lu, Chen Shen, Junmin Quan* “Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway” Bioorg. Chem. 2015, 61, 21–27.

23. Hongmei Shan, Tao Wang*, Junmin Quan*. “Crystal structure of the Polo-box Domains of Polo-like Kinase 2” BBRC, 2015, 456, 780-784. doi:10.1016/j.bbrc.2014.11.125 (The first crystal structure of the polo-box domain of polo-like kinase 2).

22. Hongmei Shan, Yanxia Shi, Junmin Quan*. “Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1” ChemMedChem. 2014, 10, 158-163 . doi: 10.1002/cmdc.201402284.

21. Jun Xu, Chen Shen, Tao Wang*, Junmin Quan* “Structural basis for the inhibition of Polo-like kinase 1” Nat. Struct. Mol. Biol. 2013, 20, 1047-53. (The first crystal structure of the complex of the kinase domain and polo-box domain of PLK1. Highlighted in cover and also by Nature China, 2 October 2013 | doi:10.1038/nchina.2013.92)

20. Lu Dai, Yuqing Liu, Junyang Liu, Xiaoming Wen, Zhengshuang Xu, Zhuo Wang, Hong Sun, Shoubin Tang, Anita R. Maguire, Junmin Quan*, Hui Zhang*, Tao Ye* “A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy.” Cancer Lett. 2013, 333, 103-112.

19. Dali Zhang, Liyan Zhou, Junmin Quan, Wei Zhang, Lianquan Gu, Zhishu Huang, Linkun An “Oxygen Insertion of o-Quinone under Catalytic Hydrogenation Conditions” Org. Lett. 2013, 13, 1162-1165.

18. Tao Chen, Feng Lu, Aaron M. Streets, Peng Fei, Junmin Quan, Yanyi Huang “Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy” Nanoscale, 2013, 5, 4701-4705.

17. Liangchun Li, Hongmei Zhan, Pengfei Duan, Jian Liao, Junmin Quan, Yu Hu, Zhongzhu Chen, Jin Zhu, Minghua Liu, Yun-dong Wu, Jingen Deng “Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides” Adv. Funct. Mater.2012, 22, 3051-3056.

16. Qi Liu, Guozong Yue, Na Wu, Guang Lin, Yuanzhen Li, Junmin Quan, Chuang-chuang Li*, Guoxing Wang*, Zhen Yang* “Total Synthesis of (+/-)-Pentalenolactone A Methyl Ester” Angew. Chem. Int. Ed.2012, 51, 12072-12076.

15. Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan*, Tao Ye*, Hui Zhang*. “Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties” Cancer Res. 2011, 71, 7238-49. (Highlighted by Nature China, 4 January 2012 | doi:10.1038/nchina.2012.1)

14. Xiaolei Wang, Junmin Quan* “Intermediate-Assisted Multifunctional Catalysis in the Conversion of Flavin to 5,6-Dimethylbenzimidazole by BluB: A Density Functional Theory Study” J. Am. Chem. Soc. 2011, 133, 4079-4091.

13. Yang Yun-Fng, Shi Ting, Zhang Xin-Hao, Tang Zong-Xun, Wen, Zhen-Yi, Quan Jun-Min, Wu Yun-Dong*. Theoretical studies on the mechanism and stereoselectivity of Rh(Phebox)-catalyzed asymmetric reductive aldol reaction. Org Biomol Chem.2011, 9, 5845-55.

12. Lintai Da, Junmin Quan, YunDong Wu* “Understanding the binding mode and function of BMS-488043 against HIV-1 viral entry” Proteins: Struct., Funct., Bioinf.2011, 79, 1810-1819.

11. Lichao Fang, Yuan Chen, Jun Huang, Lianzhu Liu, Junmin Quan, Chuang-Chuang Li*, Zhen Yang* “Formal Synthesis of Cortistatins” J. Org. Chem.2011, 76, 2479-87.

10. Yufan Liang, Lin Wang, Rong Zhu, LuJiang Deng, Yunfang Yang, Junmin Quan*, JiaHua Chen*, Zhen Yang* “An Unprecedented Silver Salt Effect Switches the Facial Selectivity in the Vinylogous Mukaiyama Aldol Reaction” Adv. Synth. Catal.2010, 352, 2387-2393.

9. Chao Che, Song Li S, Xianlong Jiang, Junmin Quan, Shuo Lin*, Zhen Yang* “One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” Org. Lett. 2010, 12, 4682-4685.

8. Haixia Zou, Liyan Zhou, Yuanzhen Li, Hanbing Zhong, Zhengying Pan, Zhen Yang*, Junmin Quan* “Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype” J. Med. Chem.2010, 53, 994-1003.

7. Chao Che, Lianzhu Liu, Jianxian Gong, Yunfang Yang, Guoxin Wang, Junmin Quan*, Zhen Yang*. “Construction of All-Carbon Quaternary Center by R2AlCl-Mediated Ring-Opening Reaction of Oxacycles” Org. Lett. 2010, 12, 488-491.

6. Yi Cui; Zhaodong Jiao, Jiangxian Gong, Quan Yu, Xiaofeng Zheng, JunminQuan*, Ming Luo*, Zhen Yang* “Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase” Org. Lett. 2010, 12, 4-7.

5. Xian-Hui Wu, Guo-Lin Zou, Jun-Min Quan, Yun-Dong Wu* “A theoretical study on the catalytic mechanism of Mus musculus adenosine deaminase” J. Comp. Chem.2010, 31, 2238-2247.

4. Hangbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, JunminQuan, Zhen Yang*, Shuo Lin* “Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.” Mol. Biosyst.2009, 5, 1356-60.

3. Jing Xiang, HongboYang, Chao Che, Haixia Zou, HongshuoYang, Yuquan Wei, JunminQuan, Hui Zhang, Zhen Yang*, Shuo Lin* “Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.” PLoS One.2009, 4, e4361.

2. Yi Cui, Hao Jiang, Zhengtao Li, Na Wu, Zhen Yang*, Junmin Quan* “Unexpected regioselectivity in the synthesis of pyranonaphthoquinone via the Diels-Alder reaction.” Org. Lett.2009, 11, 4628-31.

1. Lintai Da, JunminQuan,* Yundong Wu* “Understanding of the bridging sheet formation of HIV-1 glycoprotein gp120.” J. Phys. Chem. B.2009, 113,14536-43.

Before Independent Research:

1. Nengdong Wang, Jing Xiang, Zhibo Ma, Junmin Quan, Jiahua Chen*, and Zhen Yang* “A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives” J. Comb. Chem.; 2008; 10, 825-834.

2.  Xian-Hui Wu, Junmin Quan*, Yun-Dong Wu* “A theoretical study on the catalytic mechanism and metal ion dependence of peptide deformylase” J. Phys. Chem. B 2007, 111, 6236-6244.

3. Liu, Y.; Lu, K.; Dai, M.; Wang, K.; Wu, W.; Chen, J.; Quan, J.; Yang, Z.* “An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions” Org. Lett. 2007, 9, 805-808.

4. Chunshan Zuo, Junmin Quan, Yundong Wu “Oxa-Bicyclocalixarenes: A New Cage for Anions via C-H···Anion Hydrogen Bonds and Anion··· Interactions” Org. Lett. 2007, 9, 4219-4222.

5. Chao Che, Jing Xiang, Guo-Xin Wang, Reza Fathi, Jun-Min Quan, and Zhen Yang “One-Pot Synthesis of Quinoline-Based Tetracycles by a Tandem Three-Component Reaction” J. Comb. Chem.2007, 6, 982-989.

6. Yuanzhen Li, Haixia Zou, Jiangxian Gong, Jing Xiang, Tuopin Luo, JunminQuan, Guoxin Wang, ZhenYang “Efficient synthesis of maleimides and carbazole via Zn(Otf)2-catalyzed tandem annulaitons of isonitriles and allenic esters” Org. Lett.2007, 9, 4057-4060.

7. Dongqi Liu, Tingting Zhu, Li Fan, JunminQuan, Hongchun Guo, Jinren Ni “Identification of a novel gentisate 1,2-dioxygenase from Silicibacter pomeroyi” Biotechnol. Lett.. 2007, 29,1529-1535.

8. Yamei Yu, Yu-He Liang, Erik Brostromer, Jun-Min Quan, Santosh Panjikar, Yu-Hui Dong, Xiao-Dong Su “A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis” J. Biol. Chem. 2006, 281, 36929-36936.

9. Damon Banks , Min Wu , Leigh Ann Higa , Nadia Gavrilova , Junmin Quan , Tao Ye , Ryuji Kobayashi , Hong Sun , Hui Zhang “L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes”. Cell Cycle, 2006, 5, 1719.

10. J.-M. Quan and Y.-D. Wu “A theoretical study of the substituent effect on the stability of collagen” J. Theo & Comp Chem. 2004, 3, 225.



1. 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物。 中国专利授权号:CN101486664A.

2. Histone Demethylase Inhibitors and Uses Thereof for Treatment of Cancer 美国专利申请号:41639-514P01US.