The Quan Lab
School of Chemical Biology & Biotechnology

Peer reviewed articles

28.Jianwen Pei, Yibo Zhang, Qinhong Luo, Wenlv Zheng, Wanxuan Li, Xin Zeng, Qinkai Li, Junmin Quan*. STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity[J]. Cancer letters, 2019, 450: 110-122.

27.Chen Shen, Jianwen Pei, Xiaomin Guo, Lu Zhou, Qinkai Li & Junmin Quan*. Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8[J]. Scientific reports, 2018, 8(1): 16723.

26. Yibo Zhang, Zhen Sun, Jianwen Pei, Qinhong Luo, Xin Zeng, Qinkai Li, Zhen Yang, Junmin Quan*. “Identification of alpha-Mangostin as A Potent Agonist of Human STING”. ChemMedChem, 2018.

25. Chen Shen, Hong Yue, Jianwen Pei, Xiaomin Guo, Tao Wang*, Junmin Quan* “Crystal structure of the death effector domains of caspase-8” BBRC, 2015, 463, 297–302.

24. Hong Yue, Feng Lu, Chen Shen, Junmin Quan* “Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3β inhibitors to activate Wnt/β-catenin pathway” Bioorg. Chem. 2015, 61, 21–27.

23. Hongmei Shan, Tao Wang*, Junmin Quan*. “Crystal structure of the Polo-box Domains of Polo-like Kinase 2” BBRC, 2015, 456, 780-784. doi:10.1016/j.bbrc.2014.11.125 (The first crystal structure of the polo-box domain of polo-like kinase 2).

22. Hongmei Shan, Yanxia Shi, Junmin Quan*. “Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1” ChemMedChem. 2014, 10, 158-163 . doi: 10.1002/cmdc.201402284.

21. Jun Xu, Chen Shen, Tao Wang*, Junmin Quan* “Structural basis for the inhibition of Polo-like kinase 1” Nat. Struct. Mol. Biol. 2013, 20, 1047-53. (The first crystal structure of the complex of the kinase domain and polo-box domain of PLK1. Highlighted in cover and also by Nature China, 2 October 2013 | doi:10.1038/nchina.2013.92)

20. Lu Dai, Yuqing Liu, Junyang Liu, Xiaoming Wen, Zhengshuang Xu, Zhuo Wang, Hong Sun, Shoubin Tang, Anita R. Maguire, Junmin Quan*, Hui Zhang*, Tao Ye* “A novel CyclinE/CyclinA-CDK Inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: Implications in cancer therapy.” Cancer Lett. 2013, 333, 103-112.

19. Dali Zhang, Liyan Zhou, Junmin Quan, Wei Zhang, Lianquan Gu, Zhishu Huang, Linkun An “Oxygen Insertion of o-Quinone under Catalytic Hydrogenation Conditions” Org. Lett. 2013, 13, 1162-1165.

18. Tao Chen, Feng Lu, Aaron M. Streets, Peng Fei, Junmin Quan, Yanyi Huang “Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy” Nanoscale, 2013, 5, 4701-4705.

17. Liangchun Li, Hongmei Zhan, Pengfei Duan, Jian Liao, Junmin Quan, Yu Hu, Zhongzhu Chen, Jin Zhu, Minghua Liu, Yun-dong Wu, Jingen Deng “Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides” Adv. Funct. Mater.2012, 22, 3051-3056.

16. Qi Liu, Guozong Yue, Na Wu, Guang Lin, Yuanzhen Li, Junmin Quan, Chuang-chuang Li*, Guoxing Wang*, Zhen Yang* “Total Synthesis of (+/-)-Pentalenolactone A Methyl Ester” Angew. Chem. Int. Ed.2012, 51, 12072-12076.

15. Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan*, Tao Ye*, Hui Zhang*. “Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties” Cancer Res. 2011, 71, 7238-49. (Highlighted by Nature China, 4 January 2012 | doi:10.1038/nchina.2012.1)

14. Xiaolei Wang, Junmin Quan* “Intermediate-Assisted Multifunctional Catalysis in the Conversion of Flavin to 5,6-Dimethylbenzimidazole by BluB: A Density Functional Theory Study” J. Am. Chem. Soc. 2011, 133, 4079-4091.

13. Yang Yun-Fng, Shi Ting, Zhang Xin-Hao, Tang Zong-Xun, Wen, Zhen-Yi, Quan Jun-Min, Wu Yun-Dong*. Theoretical studies on the mechanism and stereoselectivity of Rh(Phebox)-catalyzed asymmetric reductive aldol reaction. Org Biomol Chem.2011, 9, 5845-55.

12. Lintai Da, Junmin Quan, YunDong Wu* “Understanding the binding mode and function of BMS-488043 against HIV-1 viral entry” Proteins: Struct., Funct., Bioinf.2011, 79, 1810-1819.

11. Lichao Fang, Yuan Chen, Jun Huang, Lianzhu Liu, Junmin Quan, Chuang-Chuang Li*, Zhen Yang* “Formal Synthesis of Cortistatins” J. Org. Chem.2011, 76, 2479-87.

10. Yufan Liang, Lin Wang, Rong Zhu, LuJiang Deng, Yunfang Yang, Junmin Quan*, JiaHua Chen*, Zhen Yang* “An Unprecedented Silver Salt Effect Switches the Facial Selectivity in the Vinylogous Mukaiyama Aldol Reaction” Adv. Synth. Catal.2010, 352, 2387-2393.

9. Chao Che, Song Li S, Xianlong Jiang, Junmin Quan, Shuo Lin*, Zhen Yang* “One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” Org. Lett. 2010, 12, 4682-4685.

8. Haixia Zou, Liyan Zhou, Yuanzhen Li, Hanbing Zhong, Zhengying Pan, Zhen Yang*, Junmin Quan* “Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype” J. Med. Chem.2010, 53, 994-1003.

7. Chao Che, Lianzhu Liu, Jianxian Gong, Yunfang Yang, Guoxin Wang, Junmin Quan*, Zhen Yang*. “Construction of All-Carbon Quaternary Center by R2AlCl-Mediated Ring-Opening Reaction of Oxacycles” Org. Lett. 2010, 12, 488-491.

6. Yi Cui; Zhaodong Jiao, Jiangxian Gong, Quan Yu, Xiaofeng Zheng, JunminQuan*, Ming Luo*, Zhen Yang* “Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase” Org. Lett. 2010, 12, 4-7.

5. Xian-Hui Wu, Guo-Lin Zou, Jun-Min Quan, Yun-Dong Wu* “A theoretical study on the catalytic mechanism of Mus musculus adenosine deaminase” J. Comp. Chem.2010, 31, 2238-2247.

4. Hangbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, JunminQuan, Zhen Yang*, Shuo Lin* “Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.” Mol. Biosyst.2009, 5, 1356-60.

3. Jing Xiang, HongboYang, Chao Che, Haixia Zou, HongshuoYang, Yuquan Wei, JunminQuan, Hui Zhang, Zhen Yang*, Shuo Lin* “Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.” PLoS One.2009, 4, e4361.

2. Yi Cui, Hao Jiang, Zhengtao Li, Na Wu, Zhen Yang*, Junmin Quan* “Unexpected regioselectivity in the synthesis of pyranonaphthoquinone via the Diels-Alder reaction.” Org. Lett.2009, 11, 4628-31.

1. Lintai Da, JunminQuan,* Yundong Wu* “Understanding of the bridging sheet formation of HIV-1 glycoprotein gp120.” J. Phys. Chem. B.2009, 113,14536-43.

Before Independent Research:

1. Nengdong Wang, Jing Xiang, Zhibo Ma, Junmin Quan, Jiahua Chen*, and Zhen Yang* “A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives” J. Comb. Chem.; 2008; 10, 825-834.

2.  Xian-Hui Wu, Junmin Quan*, Yun-Dong Wu* “A theoretical study on the catalytic mechanism and metal ion dependence of peptide deformylase” J. Phys. Chem. B 2007, 111, 6236-6244.

3. Liu, Y.; Lu, K.; Dai, M.; Wang, K.; Wu, W.; Chen, J.; Quan, J.; Yang, Z.* “An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions” Org. Lett. 2007, 9, 805-808.

4. Chunshan Zuo, Junmin Quan, Yundong Wu “Oxa-Bicyclocalixarenes: A New Cage for Anions via C-H···Anion Hydrogen Bonds and Anion··· Interactions” Org. Lett. 2007, 9, 4219-4222.

5. Chao Che, Jing Xiang, Guo-Xin Wang, Reza Fathi, Jun-Min Quan, and Zhen Yang “One-Pot Synthesis of Quinoline-Based Tetracycles by a Tandem Three-Component Reaction” J. Comb. Chem.2007, 6, 982-989.

6. Yuanzhen Li, Haixia Zou, Jiangxian Gong, Jing Xiang, Tuopin Luo, JunminQuan, Guoxin Wang, ZhenYang “Efficient synthesis of maleimides and carbazole via Zn(Otf)2-catalyzed tandem annulaitons of isonitriles and allenic esters” Org. Lett.2007, 9, 4057-4060.

7. Dongqi Liu, Tingting Zhu, Li Fan, JunminQuan, Hongchun Guo, Jinren Ni “Identification of a novel gentisate 1,2-dioxygenase from Silicibacter pomeroyi” Biotechnol. Lett.. 2007, 29,1529-1535.

8. Yamei Yu, Yu-He Liang, Erik Brostromer, Jun-Min Quan, Santosh Panjikar, Yu-Hui Dong, Xiao-Dong Su “A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis” J. Biol. Chem. 2006, 281, 36929-36936.

9. Damon Banks , Min Wu , Leigh Ann Higa , Nadia Gavrilova , Junmin Quan , Tao Ye , Ryuji Kobayashi , Hong Sun , Hui Zhang “L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes”. Cell Cycle, 2006, 5, 1719.

10. J.-M. Quan and Y.-D. Wu “A theoretical study of the substituent effect on the stability of collagen” J. Theo & Comp Chem. 2004, 3, 225.



1. 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物。 中国专利授权号:CN101486664A.

2. Histone Demethylase Inhibitors and Uses Thereof for Treatment of Cancer 美国专利申请号:41639-514P01US.