Quan Junmin
Junmin Quan
Principal Investigator, Associate Professor
Email: quanjm@szpku.edu.cn
Tel: 86-755-2603-5253
Fax: 86-755-26036158
EDUCATION
1993-1997 B.S. in Chemistry, Peking University
1997-2000 M.S. in Chemistry, Sun Yat-Sen University
2000-2004 Ph.D. in Computational Chemistry, The HongKong University of Science & Technology
EXPERIENCE
2009.10-Present Principal Investigator, Ph.D. Advisor
- The School of Chemical Biology and Biotechnology
- Peking University, Shenzhen Graduate School
2005.10-2008.10 Consultant in Biochemoinformatics
- XTL Biophamaceutical, New York, USA
- Program: Discovery of Small Molecule NS5A Inhibitors Against HCV
2004.10-2005.9 Consultant in Biochemoinformatics
- VivoQuest. Inc. New York, USA
- Program: Discovery of Small Molecule Inhibitors Against HCV
2006.10-2009.10 Research Assistant, Advisor: Prof. Yun-Dong Wu
- The School of Chemical Biology and Biotechnology
- Peking University, Shenzhen Graduate School
2004.8-2006.10 Postdoctoral Fellow, Advisor: Prof. Yun-Dong Wu
- The School of Chemical Biology and Biotechnology
- Peking University, Shenzhen Graduate School
HONORS AND AWARDS
2007 Best Poster Award in The 3rd Asian Pacific Conference on Theoretical & Computational Chemistry
1999 Excellent Graduate Scholarship, Sun Yat-Sen University, China
1998 DuPont Scholarship, Sun Yat-Sen University, China
1994 Motorola Excellent Scholarship, Peking University, China
1993 The Fist Class Freshman Scholarship, Peking University, China
RESEARCH INTERESTS
We apply combined computational, biochemical and biophysical approaches to characterize the atomic-level mechanisms of enzymatic catalysis and protein regulations involved in important cellular processes. Currently we focus on the mechanistic study of cofactor-independent oxygenase, and the protein-protein interactions in viral infection or cell cycle regulations.
SELECTED PUBLICATIONS
[1]. Jing Wang, Fei Lu, Qi Ren, Hong Sun, Zhengshuang Xu, Rongfeng Lan, Yuqing Liu, David Ward, Junmin Quan*, Tao Ye*, Hui Zhang*. “Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties” Cancer Res. 2011, 71, 7238-49. (Highlighted by Nature China, 2012, Jan. 4th)
[2]. Xiaolei Wang, Junmin Quan* “Intermediate-Assisted Multifunctional Catalysis in the Conversion of Flavin to 5,6-Dimethylbenzimidazole by BluB: A Density Functional Theory Study” J.Am. Chem. Soc. 2011, 133, 4079-4091.
[3]. Yang Yun-Fng, Shi Ting, Zhang Xin-Hao, Tang Zong-Xun, Wen, Zhen-Yi, Quan Jun-Min, Wu Yun-Dong. Theoretical studies on the mechanism and stereoselectivity of Rh(Phebox)-catalyzed asymmetric reductive aldol reaction. Org Biomol Chem. 2011, 9, 5845-55.
[4]. Lintai Da, Junmin Quan, YunDong Wu “Understanding the binding mode and function of BMS-488043 against HIV-1 viral entry” Proteins: Struct., Funct., Bioinf. 2011, 79, 1810-1819.
[5]. Lichao Fang, Yuan Chen, Jun Huang, Lianzhu Liu, Junmin Quan, Chuang-Chuang Li, Zhen Yang “Formal Synthesis of Cortistatins” J. Org. Chem. 2011, 76, 2479-87.
[6]. Yufan Liang, Lin Wang, Rong Zhu, LuJiang Deng, Yunfang Yang, Junmin Quan*, JiaHua Chen, Zhen Yang “An Unprecedented Silver Salt Effect Switches the Facial Selectivity in the Vinylogous Mukaiyama Aldol Reaction” Adv. Synth. Catal. 2010, 352, 2387-2393.
[7]. Chao Che, Song Li S, Xianlong Jiang, Junmin Quan, Shuo Lin, Zhen Yang “One-Pot Syntheses of Chromeno[3,4-c]pyrrole-3,4-diones via Ugi-4CR and Intramolecular Michael Addition” Org. Lett. 2010, 12, 4682-4685.
[8]. Haixia Zou, Liyan Zhou, Yuanzhen Li, Hanbing Zhong, Zhengying Pan, Zhen Yang, Junmin Quan* “Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype” J. Med. Chem. 2010, 53, 994-1003.
[9]. Chao Che, Lianzhu Liu, Jianxian Gong, Yunfang Yang, Guoxin Wang, Junmin Quan*, Zhen Yang. “Construction of All-Carbon Quaternary Center by R2AlCl-Mediated Ring-Opening Reaction of Oxacycles” Org. Lett. 2010, 12, 488-491.
[10]. Yi Cui; Zhaodong Jiao, Jiangxian Gong, Quan Yu, Xiaofeng Zheng, Junmin Quan*, Ming Luo, Zhen Yang “Development of New Stereodiverse Diaminocyclitols as Inhibitors of Influenza Virus Neuraminidase” Org. Lett. 2010, 12, 4-7.
[11]. Xian-Hui Wu, Guo-Lin Zou, Jun-Min Quan, Yun-Dong Wu “A theoretical study on the catalytic mechanism of Mus musculus adenosine deaminase” J. Comp. Chem. 2010, 31, 2238-2247.
[12]. Hangbing Zhong, Haixia Zou, Mikhail V. Semenov, Deborah Moshinsky, Xi He, Haigen Huang, Song Li, Junmin Quan, Zhen Yang, Shuo Lin “Characterization and development of novel small-molec,, u, les inhibiting GSK3 and activating Wnt signaling.” Mol. Biosyst., 2009, 5, 1356-60.
[13]. Jing Xiang, HongboYang, Chao Che, Haixia Zou, HongshuoYang, Yuquan Wei, Junmin Quan, Hui Zhang, Zhen Yang, Shuo Lin “Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays.” PLoS One. 2009, 4, e4361.
[14]. Yi Cui, Hao Jiang, Zhengtao Li, Na Wu, Zhen Yang, Junmin Quan* “Unexpected regioselectivity in the synthesis of pyranonaphthoquinone via the Diels-Alder reaction.” Org. Lett. 2009, 11, 4628-31.
[15]. Lintai Da, Junmin Quan,* Yundong Wu “Understanding of the bridging sheet formation of HIV-1 glycoprotein gp120.” J. Phys. Chem. B. 2009, 113,14536-43.
[16]. Nengdong Wang, Jing Xiang, Zhibo Ma, Junmin Quan, Jiahua Chen, and Zhen Yang “A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives” J. Comb. Chem.; 2008; 10, 825-834.
[17]. Xian-Hui Wu, Junmin Quan*, Yun-Dong Wu “A theoretical study on the catalytic mechanism and metal ion dependence of peptide deformylase” J. Phys. Chem. B 2007, 111, 6236-6244.
[18]. Liu, Y.; Lu, K.; Dai, M.; Wang, K.; Wu, W.; Chen, J.; Quan, J.; Yang, Z.* “An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels-Alder/Retro-Diels-Alder Cascade Reactions” Org. Lett. 2007, 9, 805-808.
[19]. Chunshan Zuo, Junmin Quan, Yundong Wu “Oxa-Bicyclocalixarenes: A New Cage for Anions via C-H···Anion Hydrogen Bonds and Anion··· Interactions” Org. Lett. 2007, 9, 4219-4222.
[20]. Chao Che, Jing Xiang, Guo-Xin Wang, Reza Fathi, Jun-Min Quan, and Zhen Yang “One-Pot Synthesis of Quinoline-Based Tetracycles by a Tandem Three-Component Reaction” J. Comb. Chem. 2007, 6, 982-989.
[21]. Yuanzhen Li, Haixia Zou, Jiangxian Gong, Jing Xiang, Tuopin Luo, Junmin Quan, Guoxin Wang, ZhenYang “Efficient synthesis of maleimides and carbazole via Zn(Otf)2-catalyzed tandem annulaitons of isonitriles and allenic esters” Org. Lett. 2007, 9, 4057-4060.
[22]. Dongqi Liu, Tingting Zhu, Li Fan, Junmin Quan, Hongchun Guo, Jinren Ni “Identification of a novel gentisate 1,2-dioxygenase from Silicibacter pomeroyi” Biotechnol. Lett.. 2007, 29,1529-1535
[23]. Yamei Yu, Yu-He Liang, Erik Brostromer, Jun-Min Quan, Santosh Panjikar, Yu-Hui Dong, Xiao-Dong Su “A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis” J. Biol. Chem. 2006, 281, 36929-36936.
[24]. Damon Banks , Min Wu , Leigh Ann Higa , Nadia Gavrilova , Junmin Quan , Tao Ye , Ryuji Kobayashi , Hong Sun , Hui Zhang “L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes”. Cell Cycle, 2006, 5, 1719.
[25]. J.-M. Quan and Y.-D. Wu “A theoretical study of the substituent effect on the stability of collagen” J. Theo & Comp Chem. 2004, 3, 225.
PATENS
1. 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物。 中国专利授权号：CN101486664A
2. Histone Demethylase Inhibitors and Uses Thereof for Treatment of Cancer 美国专利申请号：41639-514P01US