ABOUT US
In the past five years, our group has achieved a series of complex and biologically important natural product total syntheses, which makes those natural product synthetically accessible. The chemistry developed during our total synthesis campaign has not only helped us to deal with various challenges encountered in the syntheses of the selected target molecules, but has also opened up new avenues for synthesizing other natural products and their derivatives, which will likely result in molecules with improved biological functions and tool compounds to enable elucidation of their mechanism of actions or potential cellular targets. Our syntheses have propelled the art of total synthesis of complex natural products (see Z. Yang, “The Journey of Schinortriterpenoid Total Syntheses” Acc. Chem. Res. 2019, 52, 480−491, and Z. Yang, “Navigating the Pauson−Khand Reaction in Total Syntheses of Complex Natural Products” Acc. ...