Jianyu Long, Rudong Liu, Xinpeng Mu, Zhilin Song, Zhongchao Zhang,* and Zhen Yang*
Org. Lett. 2024, 26(15), 2960–2964
A novel strategy for the synthesis of Aspidosperma alkaloids has been achieved via a photoredox-initiated [2+2]/retro-Mannich reaction of tryptamine-substituted enaminones as a key step. The developed chemistry has been applied to the construction of the core tetracycle of Aspidosperma alkaloids (±)-aspidospermidine and (±)-limaspermidine.
