Hang Shi, Ceheng Tan, Weibin Zhang, Zichun Zhang, Rong Long, Tuoping Luo *, and Zhen Yang *
Org. Lett., 2015, 17, 2342
A highly enantio- and diastereoselective synthesis of the left-wing fragment of 11-epi-azadirachtin I characterized with the pairwise use of palladium- and gold-catalyzed cascade reactions is presented. By enlisting a sequence of stereocontrolled transformations, our 21-step route established the stereocenters of the left-wing fragment from one chiral starting material, (−)-carvone, which would significantly facilitate the synthetic studies of the azadirachtin-type limonoids.
