B. Liang, M. W. Huang, Z. J. You, Z. C. Xiong, K. Lu, R. Fathi, J. H. Chen*, Z. Yang*
J. Org. Chem. 2005, 70, 6097.
The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et3N as a base. The developed method was successfully applied to the synthesis of flavones.
