14.A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation-YANG Group

14.A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation

Y. F. Tang, Y. D. Zhang, M. J. Dai, T. P. Luo, L. J. Deng, J. H. Chen*, Z. Yang*

Org. Lett. 2005, 7, 885.

The functionalized FGH ring system of micrandilactone A was successfully constructed in high selectivity and good yields. The key reactions in our strategy are the Co−thiourea-catalyzed stereoselective, intramolecular Pauson−Khand reaction and Pd−thiourea-catalyzed stereoselective, intramolecular annulation.