David A. Price,*Heather Eng, Kathleen A. Farley,b Gilles H. Goetz, Yong Huang, Zhaodong Jiao, Amit S. Kalgutkar, Natasha M. Kablaoui, Bhagyashree Khunte, Spiros Liras, Chris Limberakis， Alan M. Mathiowetz, Roger B. Ruggeri,Jun-Min Quan and Zhen Yang
Org. Biomol. Chem. 2017, 15, 2501
The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.
