Zhongchao Zhang, Zhen Yang *
SCIENTIA SINICA Chimica 2023, 53(3), 277-288
Contiguous all carbon quaternary stereocenters are common structural units in bioactive natural products with significant synthetic challenges. In this paper, we reviewed our recent progresses in total synthesis of complex natural products containing contiguous all carbon quaternary stereocenters firstly. Then, four different synthetic strategies concerning the construction of contiguous all carbon quaternary stereocenters (≥3) were summarized. Finally, the total synthesis of waihoensene and crinipellins reported by us and other groups were taken as examples to clarify the advantages and disadvantages of various synthetic methodologies and synthetic strategies.
