Publications

72.Stereoselective Total Syntheses of (−)-Flueggine A and (+)-Virosaine B

   


Dr. Hao Wei, Chuang Qiao, Gang Liu, Prof. Dr. Zhen Yang, Prof. Dr. Chuang-chuang Li

Angew. Chem. Int. Ed. 201352, 2, 620

• Chosen as “Hot Paper” by the Editors.
• Top 3 Most Accessed Article in 11/2012.
• Highlighted in PKUSZ NEWS, 2012.
• Highlighted in Chemistry World, January, 2013.
• Highlighted in Synfacts, 2013, 9, 237 (“Synfact of the Month”).

Convergent approach: The total syntheses of (−)-flueggine A and (+)-virosaine B (see scheme) have been accomplished in a concise and convergent manner. Key steps in these approaches were relay ring-closing metathesis reactions for rapid construction of the key intermediates, and 1,3-dipolar cycloaddition reactions for the formation of the natural products.

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