Zichun Zhang, Dandan Zhao, Yingdong He, Zhen Yang, Jianxian Gong

Chin. Chem. Lett. 2019, 30 (8), 1503-1505

In this paper, we report the concise total syntheses of three botryane sesquiterpenoids: dehydrobotrydienal, dehydrobotrydienol, and 10-oxodehydrodihydrobotrydial. The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes, and further oxidative aromatization and oxidation to complete the total syntheses.