78.Development of an expedient intramolecular Pauson–Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center-YANG Group

78.Development of an expedient intramolecular Pauson–Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center

Li-Li Shi, Hong-Juan Shen, Li-Chao Fang, Jun Huang, Chuang-Chuang Li * and Zhen Yang *

Chem. Commun., 2013,49, 8806

Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson–Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.

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