Publications

178.Formation of Multiple Naturally Occurring Meroterpenoid Scaffolds by the Norrish-Yang Reaction of a p-Benzoquinone

Bing-Yan Liu+, Zi-Chun Zhang+, Zhi-Lin Song, Hong-Yi Yuan, Yuan-He Li, Zhong-Chao Zhang,* Zhen Yang*

Angew. Chem. Int. Ed. 2024, 63, e202415249

The Norrish–Yang reaction, as a typical example, demonstrates the inherent ability of photochemical reaction to facilitate formation of sterically congested C-C bonds, efficiently crafting intricate ring structure in complex organic molecules. Herein we report for the first time a unified synthesis using quinone-based acid-promoted Norrish–Yang photocyclization for the stereoselective construction of multiple avarane-type meroterpenoid natural products.