https://www.sciencedirect.com/science/article/pii/S2589004219301373?via%3Dihub
A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death
Highlights
- •CZ-48, a cell-permeant mimetic of NMN, activates SARM1 but inhibits CD38 enzymatically
- •SARM1 catalysis is similar to CD38, but with higher cyclase activity
- •Activation by CZ-48 or NMN elicits conformational changes in SARM1
- •Activation of SARM1 causes cADPR production, NAD depletion, and non-apoptotic cell death