Prof. Lee Hon Cheung （李汉璋）

Principal Investigator, PKUSZ

Email: leehoncheung@gmail.com

 

EDUCATION

1973-1978    Ph.D., Biophysics, University of California at Berkeley, USA.

1971-1973    M.S., Physics, University of California at Berkeley, USA.

1968-1971    B.A., Physics, University of California at Berkeley, USA.

 

PROFESSIONAL EXPERIENCE

Professor: 2013-present, PKUSZ, China.

Chair Professor: 2006-2013, Department of Physiology, University of Hong Kong, Hong Kong.

Adjunct Professor: 2006-present, Department of Physiology, University of Minnesota, USA.

Professor: 1999-2006, Department of Pharmacology, University of Minnesota, USA.

Professor: 1990-1999, Department of Physiology, University of Minnesota, USA.

Associate Professor:  l986-1990, Department of Physiology, University of Minnesota, USA.

Assistant Professor:  1981-1986, Department of Physiology, University of Minnesota, USA.

 

EDITORAL BOARDS

Editor-in-Chief, Messenger, 2012-present.

Editorial Board, Journal of Biological Chemistry, 2003-2008, 2013-2018.

Guest editor, special issue on “Calcium Signaling and Cyclic ADP-ribose”, Cell Biochem. Biophys., 1997.

 

Summary of Prof. Lee’s publications

李汉璋教授自回国后一直被评为“中国高引学者”（2014-2019年）

Total citations for all publications: 12,690.
Average citations/indexed article: 77.
Number of articles with at least 700 citations: 1.
Number of articles with at least 600 citations: 2.
Number of articles with at least 500 citations: 1.
Number of articles with at least 400 citations: 4.
Number of articles with at least 300 citations: 8.
Number of articles with at least 200 citations: 18.
Number of articles with at least 100 citations: 37.

Key Publications: (citations: to 6/4/2020)

[1] Howard M., Grimaldi J. C., Bazan J. F., Lund F. E., Santos-Argumedo L., Parkhouse R., Walseth T. F. and Lee H. C. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science, 1993, 262 (5136): 1056-1059. Citations: 768

[2] Galione A., Lee H. C. and Busa W. B. Ca (2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science, 1991, 253 (5024): 1143-1146. Citations: 663

[3] Clapper D. L., Walseth T., Dargie P. and Lee H. C. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. Journal of Biological Chemistry, 1987, 262 (20): 9561-9568.  Citations: 639

[4] Lee H. C., Walseth T., Bratt G. T., Hayes R. N. and Clapper D. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. Journal of Biological Chemistry, 1989, 264 (3): 1608-1615. Citations: 517.

[5] Lee H. C. Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiological reviews, 1997, 77 (4): 1133-1164. Citations: 427.

[6] Lee H. C. and Aarhus R. A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. Journal of Biological Chemistry, 1995, 270 (5): 2152-2157. Citations: 493.

[7] Lee H. C. and Aarhus R. ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite. Cell regulation, 1991, 2 (3): 203. Citations: 390. 

[8] Lee H. C., Aarhus R. and Walseth T. F. Calcium mobilization by dual receptors during fertilization of sea urchin eggs. Science, 1993, 261 (5119): 352-355. Citations: 312.

[9] Lee H. C. Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annual review of pharmacology and toxicology, 2001, 41 (1): 317-345. Citations: 475.

[10] Wu Y., Kuzma J., Maréchal E., Graeff R., Lee H. C., Foster R. and Chua N.-H. Abscisic acid signaling through cyclic ADP-ribose in plants. Science, 1997, 278 (5346): 2126-2130. Citations: 478.

[11] Lee H. C. Potentiation of calcium-and caffeine-induced calcium release by cyclic ADP-ribose. Journal of Biological Chemistry, 1993, 268 (1): 293-299. Citations: 282.

[12] Lee H. C., Aarhus R., Graeff R., Gurnack M. E. and Walseth T. F. Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin. 1994, Citations: 248

[13] Lee H. C., Aarhus R. and Levitt D. The crystal structure of cyclic ADP-ribose. Nat Struct Mol Biol, 1994, 1 (3): 143-144. Citations: 163.

[14] Prasad G. S., McRee D. E., Stura E. A., Levitt D. G., Lee H. C. and Stout C. D. Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38. Nature Structural & Molecular Biology, 1996, 3 (11): 957-964. Citations: 170.

[15] Zhao Y. J., Lam C. M. C. and Lee H. C. The membrane-bound enzyme CD38 exists in two opposing orientations. Science Signaling, 2012, 5 (241): ra67. Highlighted as Editor’s Choice in Science 337, 1434. Citations: 94.

[16] Liu J*, Zhao YJ*^&, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC^&. Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Proc Natl Acad Sci U S A. 2017, 114(31):8283–8288. Citations: 22.

[17] Zhao ZY, Xie XJ, Li WH, Liu J, Chen Z, Zhang B, Li T, Li SL, Lu JG, Zhang L, Zhang LH, Xu Z, Lee HC*, Zhao YJ*. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466. Citations: 12.