Publications-YANG Group

9.Exploring an Expedient IMDA Reaction Approach to Construct the Guanacastepene Core

C. C. Li. S. Liang, X. H. Zhang, Z. X. Xie, J. H. Chen*, Y. D.Wu*, Z. Yang* Org. Lett. 2005, 7, 3709. Construction of the [5-7-6] tricyclic core of guanacastepenes was attempted by using the intramole...

8.Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex

M. Kobori, Z. Yang, V. Heissmeyer, H. Zhu, Y. K. Jung, M. A. M. Gakidis, A. Rao, T. Sekine, F. Ikegami, C. Yuan, J. Yuan Cell Death and Differ. 2004, 11, 123. Caspase-11 is a key regulator of proinfla...

7.A Novel Thiourea Ligand Applied in the Pd-Catalyzed Heck, Suzuki, Suzuki Carbonylative Reactions

M. J. Dai, B. Liang, C. H. Wang, Z. J. You, J. Xiang, G. B. Dong, J. H. Chen*, Z Yang* Adv, Synth. Catal. 2004, 346, 1669 A novel C2 symmetrical and sterically bulky thiourea ligand 1 has been success...

6.Synthesis of Novel Palladacycles and Their Application in Heck and Suzuki Reactions under Aerobic Conditions

Z. C. Xiong, N. D. Wang, M. J. Dai, A. Li, J. H. Chen*, Z. Yang* Org. Lett. 2004, 6, 3337. Design and synthesis of a novel family of furancarbothioamide-based palladacycles are reported herein....

5.Concise Syntheisis of Isoquinoline via the Ugi and Heck Reactions

Z. Xiang, T. P. Luo, K. Lu, J. Y. Cui, X. Shi, R. Fathi, J. H. Chen*, Z. Yang* Org Lett. 2004, 6, 3155. Two types of isoquinoline scaffolds were successfully constructed in a combinatorial form...

4.Synthesis of a Novel C2-Symmetric Thiourea and Its Application in the Pd-Catalyzed Cross-Coupling Reactions with Arenediazonium Salts under Aerobic Conditions

M. J. Dai, B. Liang, C. H. Wang, J. H. Chen*, Z. Yang* Org. Lett. 2004, 6, 221. A novel thiourea-based C2-symmetric ligand was synthesized, and its application in the palladium-catalyzed Heck and Suzu...

3.Total Synthesis of Methyl Protodioscin: A Potent Agent with Anti-tumor Activity

M. S. Cheng, Q. L. Wang, Q. Tian, H. Y. Song, Y. X. Liu, Q. Li, X. Xu, H. D. Miao, X. S. Yao*, Z. Yang* J. Org. Chem. 2003, 68, 3658. Methyl protodioscin (1), otherwise known as 3-O-[α-l-rhamnopyrano...

2.Development of Thiourea-Based Ligands for the Palladium-Catalyzed Bis(methoxycarbonylation) of Terminal Olefins

M. J. Dai, C. H. Wang, J. Xiang, B. Liang, T. P. Luo, J. H. Chen*, Z. Yang*Eur. J. Org. Chem. 2003, 4346.Thiourea-based ligands were evaluated for the palladium-catalyzed bis(methoxycarbonylation) of terminal olefins. The usefulness of these ligands for this reaction is demonstrated by their stability to oxidizing agents, and their superiority in preventing palladium precipitation and double-bo...

1.Total Synthesis of Wedelolactone

C. C. Li, Z. X. Xie, Y. D. Zhang, J.H.Chen*, Z. Yang*J. Org. Chem. 2003, 68, 8500.The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-cata...